Search results for "Modality"
showing 10 items of 651 documents
Tumour-growth inhibition by induced hyperglycaemia/hyperlactacidaemia and localized hyperthermia.
1996
The present study was undertaken to exploit pathophysiological properties of solid tumours for a tumour-specific therapy. Experiments were carried out on DS-sarcomas implanted s.c. in the hind foot dorsum of Sprague Dawley rats. Treatment strategies included tumour acidification, lactate accumulation and disturbance of the microcirculation by induced systemic hyperglycaemia/hyperlact-acidaemia (15-25/10 mmol/L; for 60 min) as well as localized hyperthermia (water-bath; 43 degrees C, 30 min.). A special infusion solution was developed for the systemic treatment containing glucose, lactic acid and organic buffer without inorganic ions. Growth kinetics of tumour volume and animal survival were…
The influence of tumor blood flow and microenvironmental factors on the efficacy of radiation, drugs and localized hyperthermia.
1997
It is generally accepted that tumor blood flow, microcirculation, oxygen and nutrient supply, tissue pH distribution, and the bioenergetic status-factors which are usually closely linked and which define the so-called metabolic microenvironment--can markedly influence the therapeutic response of malignant tumors to conventional irradiation, chemotherapy, other nonsurgical treatment modalities, and the cell proliferation activity within tumors. Currently available information on the parameters defining the metabolic micromilieu in human tumors is presented in this review. According to these data, significant variations in these relevant factors are likely to occur between different locations…
Effect of hyperthermia on tumor blood flow.
1984
Differences in blood perfusion rates between tumors and normal tissue can be utilized to selectively heat many solid tumors. Blood flow in normal tissues is considerably increased at temperatures commonly applied during localized hyperthermia. In contrast, tumor blood flow may respond to localized heat typically in two different blood flow patterns: Flow may either decrease continuously with increasing exposure time and/or temperature or flow may exhibit a transient increase followed by a decline. A decrease in blood flow at high thermal doses can be observed in most of the tumors, whereas an increase in flow at low thermal doses seems to occur less frequently. The inhibition of blood flow …
Small Sample Biometric Recognition Based on Palmprint and Face Fusion
2009
Contactless biometrics provide high comfort and hygiene in person recognition. Because of this, such systems are better accepted by the general public. This paper proposes an adaptive, contactless, biometric system which combines two modalities: palmprint and face. The processing chain has been designed to overcome embedded system constraints and small sample set problem: after a palmprint is extracted from a hand image, Gabor filters are applied to both the palmprint and face in order to extract parameters, which are then used for classification. Fusion possibilities are also discussed and tested using a multimodal database of 130 people designed by the authors. High recognition performanc…
A Magnetic Resonance Imaging–Based Prediction Model for Prostate Biopsy Risk Stratification
2018
IMPORTANCE: Multiparametric magnetic resonance imaging (MRI) in conjunction with MRI–transrectal ultrasound (TRUS) fusion-guided biopsies have improved the detection of prostate cancer. It is unclear whether MRI itself adds additional value to multivariable prediction models based on clinical parameters. OBJECTIVE: To determine whether an MRI-based prediction model can reduce unnecessary biopsies in patients with suspected prostate cancer. DESIGN, SETTING, AND PARTICIPANTS: Patients underwent MRI, MRI-TRUS fusion-guided biopsy, and 12-core systematic biopsy in 1 session. The development cohort used to derive the prediction model consisted of 400 patients from 1 institution enrolled between …
Reproduction beyond cancer: A message of hope for young women
2006
Abstract Objective. Aggressive chemotherapy and radiotherapy or radical oncological surgery in young women with cancer has greatly enhanced these patients' life expectancy, but these treatments often cause infertility or premature ovarian failure due to a massive destruction of the ovarian reserve. The objective of this review is to discuss the effect of the various cancer treatments on fertility and present the various fertility sparing operations and fertility preservation strategies. Method. An extensive survey of the most up-to-date literature was performed. Results. This review discusses the impact of current cancer treatment on fertility potential and the various surgical and assisted…
The addition of interleukin-2 to cyclophosphamide therapy can facilitate tumor growth of B16 melanoma.
1995
The role of interleukin-2 (IL-2) on tumor growth of B16F10 melanoma cells was assessed in two sets of mice with different immune status: normal (immunocompetent) mice and immunodeficient mice. The two sets of animals were treated with cyclophosphamide (CY) or IL-2 alone or with a combined therapy of CY+IL-2. On days 6 and 10 after tumor cell injection, we evaluated the incidence of hepatic B16 melanoma metastases and the percentage of hepatic volume occupied by metastatic tissue. We observed that the CY alone (300 mg/kg, days 3 and 8 post-tumoral inoculation) significantly reduced tumor growth in all treated mice; however, CY proved more effective in normal recipients than in immunodeficien…
Learning cultural literacy through creative practices in schools cultural and multimodal approaches to meaning-making
2022
Introduction: Cultural Literacy and Creativity -- A Sociocultural Approach to Children’s Visual Creations -- Multimodality: Art as a Meaning-Making Process -- Tolerance, Empathy, and Inclusion -- Living Together -- Social Responsibility -- Belonging and Home -- Cultural Literacy During COVID-19 -- Conclusions: Cultural Literacy in Action -- Index. This open access book discusses how cultural literacy can be taught and learned through creative practices. It approaches cultural literacy as a dialogic social process based on learning and gaining knowledge through emphatic, tolerant, and inclusive interaction. The book focuses on meaning-making in children and young people’s visual and multimod…
On the Convergence of Affective and Persuasive Technologies in Computer-Mediated Health-Care Systems
2015
This paper offers a portrayal of how affective computing and persuasive technologies can converge into an effective tool for interfacing biomedical engineering with behavioral sciences and medicine. We describe the characteristics, features, applications, present state of the art, perspectives, and trends of both streams of research. In particular, these streams are analyzed in light of the potential contribution of their convergence for improving computer-mediated health-care systems, by facilitating the modification of patients’ attitudes and behaviors, such as engagement and compliance. We propose a framework for future research in this emerging area, highlighting how key constructs and …
Evidencialitātes izteikšanas līdzekļi latviešu valodā
2014
Anotācija Promocijas darbs „Evidencialitātes izteikšanas līdzekļi latviešu valodā” uzskatāms par pirmo pētījumu, kas par galveno analīzes objektu izvirza evidencialitāti un tās izpausmi latviešu valodā. Evidencialitāte ir semantiska kategorija, kuras galvenā funkcija ir norāde uz informācijas ieguves avotu. Darba mērķis – analizēt evidencialitāti kā semantisku kategoriju, balstoties latviešu valodas materiālā. Promocijas darba teorētiskajā daļā aplūkota evidencialitātes jēdziena izpratne valodniecībā un analīzes iespējas, tās vēsturiskie aizsākumi un attīstība līdz mūsdienām, tipoloģija, tiešas un netiešas informācijas šķīrums un ar to saistītā problemātika, epistēmiskās modalitātes un evid…