Search results for "Modeling and Simulation"
showing 10 items of 1561 documents
Prokaryotic symbiotic consortia and the origin of nucleated cells: A critical review of Lynn Margulis hypothesis.
2021
The publication in the late 1960s of Lynn Margulis endosymbiotic proposal is a scientific milestone that brought to the fore of evolutionary discussions the issue of the origin of nucleated cells. Although it is true that the times were ripe, the timely publication of Lynn Margulis' original paper was the product of an intellectually bold 29-years old scientist, who based on the critical analysis of the available scientific information produced an all-encompassing, sophisticated narrative scheme on the origin of eukaryotic cells as a result of the evolution of prokaryotic consortia and, in bold intellectual stroke, put it all in the context of planetary evolution. A critical historical reas…
Immune networks: multitasking capabilities near saturation
2013
Pattern-diluted associative networks were introduced recently as models for the immune system, with nodes representing T-lymphocytes and stored patterns representing signalling protocols between T- and B-lymphocytes. It was shown earlier that in the regime of extreme pattern dilution, a system with $N_T$ T-lymphocytes can manage a number $N_B!=!\order(N_T^\delta)$ of B-lymphocytes simultaneously, with $\delta!<!1$. Here we study this model in the extensive load regime $N_B!=!\alpha N_T$, with also a high degree of pattern dilution, in agreement with immunological findings. We use graph theory and statistical mechanical analysis based on replica methods to show that in the finite-connectivit…
Corrigendum: Partial inner product spaces, metric operators and generalized hermiticity
2013
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Influence of inorganic pyrophosphate on the kinetics of muscle pyruvate kinase: a simple nonallosteric feedback model.
2002
Potassium pyrophosphate was used instead of ATP as a model ligand for magnesium cation for the study of effector influence on the kinetics of pyruvate kinase muscle isozyme M1. The pyruvate kinase activation by low concentration of pyrophosphate and inhibition by high concentration of pyrophosphate was considered to be the result of reversible reactions of magnesium cation with pyrophosphate, ADP, ATP, and PEP. The apparent Km and Vm or in some cases the pseudo-first order reaction rate constant (instead of Km and Vm) of pyruvate kinase at any given pyrophosphate concentration were analysed as a function of concentration of free magnesium cation and its complexes with all ligands present in…
Updating input–output matrices: assessing alternatives through simulation
2009
A problem that frequently arises in economics, demography, statistics, transportation planning and stochastic modelling is how to adjust the entries of a matrix to fulfil row and column aggregation constraints. Biproportional methods in general and the so-called RAS algorithm in particular, have been used for decades to find solutions to this type of problem. Although alternatives exist, the RAS algorithm and its extensions are still the most popular. Apart from some interesting empirical and theoretical properties, tradition, simplicity and very low computational costs are among the reasons behind the great success of RAS. Nowadays computer hardware and software have made alternative proce…
Dissipation and entanglement dynamics for two interacting qubits coupled to independent reservoirs
2008
We derive the master equation of a system of two coupled qubits by taking into account their interaction with two independent bosonic baths. Important features of the dynamics are brought to light, such as the structure of the stationary state at general temperatures and the behaviour of the entanglement at zero temperature, showing the phenomena of sudden death and sudden birth as well as the presence of stationary entanglement for long times. The model here presented is quite versatile and can be of interest in the study of both Josephson junction architectures and cavity-QED.
Vortex length, vortex energy and fractal dimension of superfluid turbulence at very low temperature
2010
By assuming a self-similar structure for Kelvin waves along vortex loops with successive smaller scale features, we model the fractal dimension of a superfluid vortex tangle in the zero temperature limit. Our model assumes that at each step the total energy of the vortices is conserved, but the total length can change. We obtain a relation between the fractal dimension and the exponent describing how the vortex energy per unit length changes with the length scale. This relation does not depend on the specific model, and shows that if smaller length scales make a decreasing relative contribution to the energy per unit length of vortex lines, the fractal dimension will be higher than unity. F…
Inhomogeneous spatio-temporal point processes on linear networks for visitors’ stops data
2022
We analyse the spatio-temporal distribution of visitors' stops by touristic attractions in Palermo (Italy) using theory of stochastic point processes living on linear networks. We first propose an inhomogeneous Poisson point process model, with a separable parametric spatio-temporal first-order intensity. We account for the spatial interaction among points on the given network, fitting a Gibbs point process model with mixed effects for the purely spatial component. This allows us to study first-order and second-order properties of the point pattern, accounting both for the spatio-temporal clustering and interaction and for the spatio-temporal scale at which they operate. Due to the strong d…
Splitting the dynamics of large biochemical interaction networks
2003
This article is inscribed in the general motivation of understanding the dynamics on biochemical networks including metabolic and genetic interactions. Our approach is continuous modeling by differential equations. We address the problem of the huge size of those systems. We present a mathematical tool for reducing the size of the model, master-slave synchronization, and fit it to the biochemical context.
Distribution of oxygen partial pressure in a two-dimensional tissue supplied by capillary meshes and concurrent and countercurrent systems
1969
Abstract For the calculations of oxygen partial pressure in a two-dimensional tissue model supplied by a capillary network (inhomogeneously perfused tissue), two differential equations are given that describe the process in the tissue and capillaries. The differential equations are coupled by the boundary conditions. Results obtained by using the method of successive displacements are given for the two-dimensional problem. This method exhibits a satisfactory convergence. The accuracy of the results is about ±5% based on the initial concentration. The results for the network model are compared with those for equivalent concurrent and countercurrent systems. Equivalence means in this connecti…