Search results for "Modelli"

Consensus modelling and molecular dynamics studies for the identification of novel telomerase inhibitors as anti-cancer agents

2018

Telomerase plays an important role in early stages of life-maintaing telomere and chromosomal integrity of frequently dividing cells. It turns dormant in most somatic cells during adulthood. However, in cancer cells, telomerase gets reactivated and works tirelessly to maintain the length of telomeres, leading to immortality of cells. Hence, in this study, we have used a combined ligand-based and structure based drug design approach for the identification of novel telomerase inhibitors as anti-cancer agents. We have generated ligand-based QSAR models and structure-based pharmacophores models, according our recent MYSHAPE approach (1), and validated exhaustively. The validated models were use…

LA PERCEZIONE DEL TEMPO

2005

This paper reviews psychological research on time perception. In view of the wastness of this topic, we only focus on temporal memory, i.e. time duration estimation. We will present the main psychological theories, elaborated in the first laboratories.Finally, both the current cognitivist and chronobiological models and theories will be introduced.

ModeLTER : modelling of landscapes and territories over the long term, the members of an European Associated Laboratory (EAL) in CAENTI.

2006

International audience; The aim of this new project is the modelisation of landscapes and territories over the long term. This has been a topic that engaged the proposed research team for several years, particularly in the frame of two European projects, Archeomedes I & II, during the 1990s (Van der Leeuw S., Favory F., Fiches J.- L. (eds.) 2003, Favory F., Girardot J.-J., van der Leeuw S. 2004). Both French and Slovenian teams were involved in the project by Professors S. Van der Leeuw and Z. Stančič. Since this period, the collaboration of French and Slovenian researchers increased in activity, and it finds now a new organization in an European Associated Laboratory, linking archaeologist…

Coherence properties in superconducting flux qubits

The research work discussed in this thesis deals with the study of superconducting Josephson qubits. Superconducting qubits are solid-state artificial atoms which are based on lithographically defined Josephson tunnel junctions properties. When sufficiently cooled, these superconducting devices exhibit quantized states of charge, flux or junction phase depending on their design parameters. This allows to observe coherent evolutions of their states. The results presented can be divided into two parts. In a first part we investigate operations of superconducting qubits based on the quantum coherence in superconducting quantum interference devices (SQUID). We explain experimental data which ha…

Experimental campaign to assess numerical simulation of tool wear in orthogonal cutting

2007

Siracusa e la Sicilia nel III secolo a.C.: problemi conoscitivi e proposte di lettura dei fenomeni urbanistici e architettonici

2017

L’evoluzione sotto il profilo urbanistico e architettonico delle città di Sicilia nel III secolo a.C. può essere compresa solo a partire da un esame delle evidenze di Siracusa, la maggiore città dell’Occidente greco-ellenistico e capitale di un regno che sotto Agatocle e soprattutto sotto Ierone II vede un prodigioso sviluppo non solo per l’estensione dell’area urbana, ma soprattutto per la riconfigurazione dello spazio cittadino in forme innovative, destinate a influenzare in maniera decisiva anche le città minori del regno e dell’Oriente dell’isola, e successivamente anche dei comprensori centro-occidentali e settentrionali. L’aspetto più importante e programmatico nella rimodulazione del…

Transient behaviour of a MSF desalination unit: modelling and experiments

2008

Comparison of a MBR system start-up with and without inoculum: experimental and mathematical model application

2010

The performance of a membrane bioreactor (MBR) system and the extension and mechanisms that lead to the formation of the fouling may differ in relation to the start-up. As a consequence, the MBR start-up may constitute a crucial point that drastically influence the MBR performance in its lifespan. Indeed, the start-up influences the mechanisms of membrane fouling whose effects, in the case of irreversible cake deposition, can be modified only by a chemical membrane washing. In order to gain insights about the effect of the start-up on a MBR system, a MBR pilot plant was build-up and a mathematical model developed. The MBR system was constituted by a hollow fibre membrane module installed in…

A model for wastewater organic removal and fouling development in a SMBR pilot plant

2007

The paper presents the setting up of a mathematical model for membrane bioreactor able to simulate physical-biological wastewater organic removal. The model is basically divided into two sub-models: the first sub-model is basically devoted for the simulation of the biological features and the second one for the physical processes. In particular regarding the biological aspects, the ASM concept has been employed. On the other hand, the physical processes have been modelled considering the deep-bed theory taking into account not only the effect of the physical membrane filtration but also the cake layer effect. This latter operates as a biological membrane leading to a further reduction of th…

Erosion, screening, and migration of tungsten in the JET divertor

2019

The erosion of tungsten (W), induced by the bombardment of plasma and impurity particles, determines the lifetime of plasma-facing components as well as impacting on plasma performance by the influx of W into the confined region. The screening of W by the divertor and the transport of W in the plasma determines largely the W content in the plasma core, but the W source strength itself has a vital impact on this process. The JET tokamak experiment provides access to a large set of W erosion-determining parameters and permits a detailed description of the W source in the divertor closest to the ITER one: (i) effective sputtering yields and fluxes as function of impact energy of intrinsic (Be,…