Search results for "Modelling"
showing 10 items of 1353 documents
Valence change ReRAMs (VCM) - Experiments and modelling: General discussion
2019
Valence change ReRAMs (VCM) - Experiments and modelling: General discussion
Multimodality of rich clusters from the SDSS DR8 within the supercluster-void network
2012
We study the relations between the multimodality of galaxy clusters drawn from the SDSS DR8 and the environment where they reside. As cluster environment we consider the global luminosity density field, supercluster membership, and supercluster morphology. We use 3D normal mixture modelling, the Dressler-Shectman test, and the peculiar velocity of cluster main galaxies as signatures of multimodality of clusters. We calculate the luminosity density field to study the environmental densities around clusters, and to find superclusters where clusters reside. We determine the morphology of superclusters with the Minkowski functionals and compare the properties of clusters in superclusters of dif…
On the measurement of local gas hold-up and interfacial area in gas–liquid contactors via light sheet and image analysis
2010
Abstract Particle image velocimetry techniques coupled with advanced image processing tools are receiving an increasing interest for measuring flow quantities and local bubble-size distributions in gas–liquid contactors. Aim of this work is that of providing a numerical procedure able to reconstruct local gas hold-up and specific interfacial area from images obtained by laser sheet illumination. A correction for measured quantities accounting for laser sheet thickness is proposed and tested by means of Monte Carlo simulations. The algorithms proposed are robust and independent of any measured parameters of the actual bubble size distribution.
Time-domain-induced polarization: Full-decay forward modeling and 1D laterally constrained inversion of Cole-Cole parameters
2012
Time-domain-induced polarization has significantly broadenedits field of reference during the last decade, from mineralexploration to environmental geophysics, e.g., for clay and peatidentification and landfill characterization. Though, insufficientmodeling tools have hitherto limited the use of time-domaininducedpolarization for wider purposes. For these reasons, anew forward code and inversion algorithm have been developedusing the full-time decay of the induced polarization response,together with an accurate description of the transmitter waveformand of the receiver transfer function, to reconstruct thedistribution of the Cole-Cole parameters of the earth. The accuratemodeling of the tra…
Characterisation and mitigation of beam-induced backgrounds observed in the ATLAS detector during the 2011 proton-proton run
2013
This paper presents a summary of beam-induced backgrounds observed in the ATLAS detector and discusses methods to tag and remove background contaminated events in data. Triggerrate based monitoring of beam-related backgrounds is presented. The correlations of backgrounds with machine conditions, such as residual pressure in the beam-pipe, are discussed. Results from dedicated beam-background simulations are shown, and their qualitative agreement with data is evaluated. Data taken during the passage of unpaired, i.e. non-colliding, proton bunches is used to obtain background-enriched data samples. These are used to identify characteristic features of beam-induced backgrounds, which then are …
A measurement of material in the ATLAS tracker using secondary hadronic interactions in 7 TeV pp collisions
2016
Knowledge of the material in the ATLAS inner tracking detector is crucial in understanding the reconstruction of charged-particle tracks, the performance of algorithms that identify jets containing b-hadrons and is also essential to reduce background in searches for exotic particles that can decay within the inner detector volume. Interactions of primary hadrons produced in pp collisions with the material in the inner detector are used to map the location and amount of this material. The hadronic interactions of primary particles may result in secondary vertices, which in this analysis are reconstructed by an inclusive vertex-finding algorithm. Data were collected using minimum-bias trigger…
Stochastic description of traffic breakdown
2003
We present a comparison of nucleation in an isothermal-isochoric container with traffic congestion on a one-lane freeway. The analysis is based, in both cases, on the probabilistic description by stochastic master equations. Further we analyze the characteristic features of traffic breakdowns. To describe this phenomenon we apply the stochastic model regarding the jam emergence to the formation of a large car cluster on the highway.
Formulation predictive dissolution (fPD) testing to advance oral drug product development: an introduction to the US FDA funded ‘21st Century BA/BE’ …
2018
Over the past decade, formulation predictive dissolution (fPD) testing has gained increasing attention. Another mindset is pushed forward where scientists in our field are more confident to explore the in vivo behavior of an oral drug product by performing predictive in vitro dissolution studies. Similarly, there is an increasing interest in the application of modern computational fluid dynamics (CFD) frameworks and high-performance computing platforms to study the local processes underlying absorption within the gastrointestinal (GI) tract. In that way, CFD and computing platforms both can inform future PBPK-based in silico frameworks and determine the GI-motility-driven hydrodynamic impac…
In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for for…
2013
This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to investigate the effects of excipients and the role of food on drug absorption. One goal of the authors was to clearly identify the gaps in today's knowledge in order to stimulate further work on refining the e…
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and ov…
2016
Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation development by providing quantitative predictions through a systems approach. The performance of three available PBPK software packages (GI-Sim, Simcyp®, and GastroPlus™) were evaluated by comparing simulated and observed pharmacokinetic (PK) parameters.Since the availability of input parameters was heterogeneous and highly variable, caution is required when interpreting the results of this exercise. Additionally, this prospective simulation exer…