Search results for "Models"
showing 10 items of 8211 documents
Minireview: Nicotinic Acetylcholine Receptors on Hippocampal Neurons: Distribution on the Neuronal Surface and Modulation of Receptor Activity
1997
The recent development of a technique that uses infrared microscopy for the visualization of well-defined areas on the surface of neurons, and a computerized system of micromanipulators led to the discovery that functional nicotinic acetylcholine receptors (nAChRs) are expressed at higher density on the dendrites than on the soma of rat hippocampal neurons. The finding that the expression of alpha-bungarotoxin-sensitive, alpha 7-bearing, nAChRs and dihydro-beta-erythroidine-sensitive, alpha 4 beta 2 nAChRs tends to increase along the dendritic length suggests that these receptors may be highly involved in the integration of synaptic functions in hippocampal neurons. The present report also …
Endotoxaemia resulting from decreased serotonin tranporter (5-HTT) function: A reciprocal risk factor for depression and insulin resistance?
2015
International audience; Depression and diabetes are serious diseases with an increasing global prevalence. Intriguingly, recent meta-analyses have highlighted an asymmetrical relationship between the two conditions as depressed patients were found to display a higher risk of developing type 2 diabetes than those individuals suffering from diabetes are to become depressed. Based on recent findings, we favor a hypothesis where by decreased peripheral serotonin (5-HT) transporter (5-HTT) function is a reciprocal risk factor for the comorbidity of depression and diabetes, as it can trigger inflammatory pathogenetic mechanisms of both conditions. Higher intestinal levels of 5-HT and 5-HT3 recept…
Phenotypic and genotypic characterization of a new fish-virulent Vibrio vulnificus serovar that lacks potential to infect humans.
2007
Vibrio vulnificus is a bacterial species that is virulent for humans and fish. Human isolates are classified into biotypes 1 and 3 (BT1 and BT3) and fish isolates into biotype 2 (BT2). However, a few human infections caused by BT2 isolates have been reported worldwide (zoonosis). These BT2 human isolates belong to serovar E (SerE), which is also present in diseased fish. The aim of the present work was to characterize a new BT2 serovar [serovar A (SerA)], which emerged in the European fish-farming industry in 2000, by means of phenotypic, serological and genetic [plasmid profiling, ribotyping and random amplified polymorphic DNA (RAPD)] methodologies. The results confirmed that SerA constit…
Genomic Epidemiology of Salmonella Infantis in Ecuador: From Poultry Farms to Human Infections
2020
Salmonella enterica is one of the most important foodborne pathogens around the world. In the last years, S. enterica serovar Infantis has become an important emerging pathogen in many countries, often as multidrug resistant clones. To understand the importance of S. enterica in the broiler industry in Ecuador, we performed a study based on phenotypic and WGS data of isolates from poultry farms, chicken carcasses and humans. We showed a high prevalence of S. enterica in poultry farms (41.4%) and chicken carcasses (55.5%), but a low prevalence (1.98%) in human samples. S. Infantis was shown to be the most prevalent serovar with a 98.2, 97.8, and 50% in farms, foods, and humans, respectively,…
Host-Nonspecific Iron Acquisition Systems and Virulence in the Zoonotic Serovar of Vibrio vulnificus
2014
ABSTRACT The zoonotic serovar of Vibrio vulnificus (known as biotype 2 serovar E) is the etiological agent of human and fish vibriosis. The aim of the present work was to discover the role of the vulnibactin- and hemin-dependent iron acquisition systems in the pathogenicity of this zoonotic serovar under the hypothesis that both are host-nonspecific virulence factors. To this end, we selected three genes for three outer membrane receptors ( vuuA , a receptor for ferric vulnibactin, and hupA and hutR , two hemin receptors), obtained single and multiple mutants as well as complemented strains, and tested them in a series of in vitro and in vivo assays, using eels and mice as animal models. Th…
Serum Response Factor-Mediated Gene Regulation in a Drosophila Visual Working Memory
2013
Summary Background Navigation through the environment requires a working memory for the chosen target and path integration facilitating an approach when the target becomes temporarily hidden. We have previously shown that this visual orientation memory resides in the ellipsoid body, which is part of the central complex in the Drosophila brain. Former analysis of foraging and ignorant mutants have revealed that a hierarchical PKG and RSKII kinase signaling cascade in a subset of the ellipsoid-body ring neurons is required for this type of working memory in flies. Results Here we show that mutants in the ellipsoid body open ( ebo ) gene, which encodes the actin-binding protein Exportin 6, e…
Vertical take-off and landing air transport to provide tourist mobility.
2012
Abstract This paper examines helicopter transfer services to reach attractive and not very accessible tourist areas, taking Sicily and its minor islands, in the South of Italy, as a case study. We investigate the viability of helicopter scheduled services for tourists moving from/to airports or doing one day tours to visit far away places. The mode choice of tourists is simulated using random utility models employing stated preference data. Heli-shuttle service is planned in terms of fleet size, frequency, fare and location pattern of heliports. The paper also analyses how a public subsidy reducing fares might change the set of feasible connections.
A weighted logistic regression for conjoint analysis and Kansei engineering
2007
Customer needs for emotional satisfaction are increasingly being considered by product and service designers. While several existing methods such as conjoint analysis (CA), Kano model and quality function deployment support the translation of customer requirements into technical specifications, researchers are now working to develop methods aimed at integrating affective aspects into product design. Kansei engineering (KE) is a design philosophy that considers customer perceptions and emotions by adopting a multi-disciplinary approach. CA is a useful tool within a KE project. This article presents a methodology for conducting a KE project in early development phases. This methodology is bas…
Systemic Development of Service Innovation
2015
This chapter explores the intrinsic characteristics of services and service systems and presents systemic approach to produce service innovations. The chapter consists of elaborating the characteristics of services and the principles of systemic development, discussing service matrixes, service systems, service strategies and business models, and special challenges related to the development of services and service innovations. Services are always produced in service systems consisting of combination of service personnel and information systems. Customers are involved in these systems by interacting with the front end of service organization. The key issue in service development and innovat…
Modeling Ordinal Item Responses via Binary GLMMs and Alternative Link Functions: An Application to Measurement of a Perceived Service Quality
2010
Evaluation of a service on the basis of consumer opinion is a widespread practice in many fields. The assessment of perceived quality [7] of a service is generally carried out through administration of a questionnaire, composed of several items with responses posed on an ordinal scale, whereby each item represents an important feature of the evaluated service [3, 7]. In this context, the aim is to evaluate something similar to the external effectiveness, that is the part of efficacy related to the satisfaction expressed by the service users for the provided service. A particular and important example of service users is represented by students’ responses measuring the perceived quality of s…