Search results for "Models"

LAAE-14, a new in vitro inhibitor of intracellular calcium mobilization, modulates acute and chronic inflammation.

2003

Abstract A new lipidic acid-amido ether derivative (LAAE-14) able to reduce dose-dependently the calcium increases mediated either by calcium ionophore ionomycin, by the endoplasmic reticular Ca 2+ -ATPase inhibitor thapsigargin, or by the chemotactic tripeptide N -formyl- l -methionyl- l -leucyl- l -phenylalanine (fMLP), in human neutrophils as well as in murine peritoneal macrophages, but not ATP, has been evaluated as a potential anti-inflammatory drug. This compound attenuated leukocyte activation by means of its inhibitory effect on the respiratory burst elicited in both types of cells by 12- O -tetradecanoyl phorbol 13-acetate, by inhibition of the degranulation process induced by cyt…

Henkilöhahmon sisäinen konflikti Väinö Linnan romaanissa Tuntematon sotilas

2015

The object of this study is character´s internal conflict in the novel. The primary research question is: What are the internal conflicts of characters like in Väinö Linna’s novel The Unknown Soldier? An answer to the primary research question is sought by answering the following secondary research questions: What are the specific internal conflicts like? How do they manifest? What are the most important effects they have on the structure of the narrative? What kinds of groups of characters are possible to form? How could the traditional notion of characters internal conflict, as it is traditionally defined in literary studies, be developed? In this study, internal conflict takes place when…

Non-Linear Hysteretic Instability in Rotating Machinery

2013

Droghe leggere e criminalità organizzata: una relazione problematica

2022

Il contributo analizza il tema dei rapporti tra trattamento penale delle droghe c.d. “leggere” e contrasto alla criminalità organizzata dedita al narcotraffico, con riguardo all’ordinamento europeo, internazionale e di alcuni Paesi dell’UE (Spagna, Portogallo, Grecia, Germania e Italia). Seguendo un approccio di tipo integrato, all’analisi del dato normativo si affianca la descrizione della fenomenologia dei traffici e la valutazione dei primi effetti che le riforme antiproibizioniste entrate in vigore in alcuni ordinamenti del Nord e del Sud America hanno prodotto sul fronte del mercato illecito. Il fine è di evidenziare i punti di forza e di debolezza dei modelli di depenalizzazione, tene…

La cattedrale di Palermo

2015

Il volume ripercorre le principali vicende architettoniche della cattedrale di Palermo dalle origini fino al Novecento, individuandone nella sua complessa storia plurisecolare i committenti, gli artefici e i modelli di riferimento.

A solution to the stochastic point location problem in metalevel nonstationary environments.

2008

This paper reports the first known solution to the stochastic point location (SPL) problem when the environment is nonstationary. The SPL problem involves a general learning problem in which the learning mechanism (which could be a robot, a learning automaton, or, in general, an algorithm) attempts to learn a "parameter," for example, lambda*, within a closed interval. However, unlike the earlier reported results, we consider the scenario when the learning is to be done in a nonstationary setting. For each guess, the environment essentially informs the mechanism, possibly erroneously (i.e., with probability p), which way it should move to reach the unknown point. Unlike the results availabl…

OpenCMISS: A multi-physics & multi-scale computational infrastructure for the VPH/Physiome project

2011

The VPH/Physiome Project is developing the model encoding standards CellML (cellml.org) and FieldML (fieldml.org) as well as web-accessible model repositories based on these standards (models.physiome.org). Freely available open source computational modelling software is also being developed to solve the partial differential equations described by the models and to visualise results. The OpenCMISS code (opencmiss.org), described here, has been developed by the authors over the last six years to replace the CMISS code that has supported a number of organ system Physiome projects. OpenCMISS is designed to encompass multiple sets of physical equations and to link subcellular and tissue-level b…

Statistically validated networks in bipartite complex systems.

2011

Many complex systems present an intrinsic bipartite nature and are often described and modeled in terms of networks [1-5]. Examples include movies and actors [1, 2, 4], authors and scientific papers [6-9], email accounts and emails [10], plants and animals that pollinate them [11, 12]. Bipartite networks are often very heterogeneous in the number of relationships that the elements of one set establish with the elements of the other set. When one constructs a projected network with nodes from only one set, the system heterogeneity makes it very difficult to identify preferential links between the elements. Here we introduce an unsupervised method to statistically validate each link of the pr…

Random Tanglegram Partitions (Random TaPas): An Alexandrian Approach to the Cophylogenetic Gordian Knot

2018

Abstract Symbiosis is a key driver of evolutionary novelty and ecological diversity, but our understanding of how macroevolutionary processes originate extant symbiotic associations is still very incomplete. Cophylogenetic tools are used to assess the congruence between the phylogenies of two groups of organisms related by extant associations. If phylogenetic congruence is higher than expected by chance, we conclude that there is cophylogenetic signal in the system under study. However, how to quantify cophylogenetic signal is still an open issue. We present a novel approach, Random Tanglegram Partitions (Random TaPas) that applies a given global-fit method to random partial tanglegrams of …

Asymmetric Comparison and Querying of Biological Networks

2011

Comparing and querying the protein-protein interaction (PPI) networks of different organisms is important to infer knowledge about conservation across species. Known methods that perform these tasks operate symmetrically, i.e., they do not assign a distinct role to the input PPI networks. However, in most cases, the input networks are indeed distinguishable on the basis of how the corresponding organism is biologically well characterized. In this paper a new idea is developed, that is, to exploit differences in the characterization of organisms at hand in order to devise methods for comparing their PPI networks. We use the PPI network (called Master) of the best characterized organism as a …