Search results for "Models"
showing 10 items of 8211 documents
Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction
2015
Up to 80% of individuals with myotonic dystrophy type 1 (DM1) will develop cardiac abnormalities at some point during the progression of their disease, the most common of which is heart blockage of varying degrees. Such blockage is characterized by conduction defects and supraventricular and ventricular tachycardia, and carries a high risk of sudden cardiac death. Despite its importance, very few animal model studies have focused on the heart dysfunction in DM1. Here, we describe the characterization of the heart phenotype in a Drosophila model expressing pure expanded CUG repeats under the control of the cardiomyocyte-specific driver GMH5-Gal4. Morphologically, expression of 250 CUG repeat…
Environmental spillovers and their impacts on housing prices: A spatial hedonic analysis
2015
This paper investigates the spatial dimension of environmental factors on housing prices. We develop spatial hedonic models to estimate the implicit prices of various environmental attributes. The spatial dimension can be interpreted in terms of local or global spillovers. We conduct an empirical study in the Loire estuary (France). We focus on natural areas and more artificialized ones (ocean frontage, wetlands, rivers, and noisy roads). We show that, depending on the spatial model used, the implicit price is more than just the estimated coefficient value and combines both a feedback effect and a propagation effect.
Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome
2014
Fetal alcohol spectrum disorder (FASD) is a frequent cause of mental retardation. However, the molecular mechanisms underlying brain development defects induced by maternal alcohol consumption during pregnancy are unclear. We used normal and Hsf2-deficient mice and cell systems to uncover a pivotal role for heat shock factor 2 (HSF2) in radial neuronal migration defects in the cortex, a hallmark of fetal alcohol exposure. Upon fetal alcohol exposure, HSF2 is essential for the triggering of HSF1 activation, which is accompanied by distinctive post-translational modifications, and HSF2 steers the formation of atypical alcohol-specific HSF1–HSF2 heterocomplexes. This perturbs the in vivo bindi…
Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process
2012
International audience; Candida albicans frequently causes superficial infections by invading and damaging epithelial cells, but may also cause systemic infections by penetrating through epithelial barriers. C. albicans is a remarkable pathogen because it can invade epithelial cells via two distinct mechanisms: induced endocytosis, analogous to facultative intracellular enteropathogenic bacteria, and active penetration, similar to plant pathogenic fungi. Here we investigated the contributions of the two invasion routes of C. albicans to epithelial invasion. Using selective cellular inhibition approaches and differential fluorescence microscopy, we demonstrate that induced endocytosis contri…
Formalization of scientific process and conceptual modelling for the study of territorial and products distribution dynamics (ArchaeDyn II programme)
2012
International audience; The ArchaeDyn team has investigated territorial dynamics by comparing areas over long time spans between the Neolithic and Modern times. Datasets on various themes have been shared and indicators and analytical models produced. This paper presents both the formalization of the scientific process used in the ArchaeDyn programme and a conceptual model of the systems and components so that synchronic and diachronic comparisons can be made. The aim is to clarify the transition from an archaeological feature (a site or an artefact) or a recording unit (survey area) as the input, to the characterization of spaces describing a system as the output. The approach is described…
From Archaeomedes to Archaedyn
2007
International audience
Peer effects in the light of students interactions and the subjective dimensions of school experience
2011
This Thesis addresses the issue of peer-effects in the context of school. From analysis of a large database produced by a Chilean national study (SIMCE 2004), this work investigates the mechanisms through which pupils with different levels of scholastic, human and cultural capital influence each other. These influences seem present for a diverse range of school outcomes, including academic achievement. Drawing on the literature produced by different disciplinary approaches —sociology, economics, social psychology and education— the study focuses on ways of identifying and measuring peer-effects. The presence of subjective dimensions capable of reflecting, in part, the school experience of p…
Pricing the homebuyer's countryside view
2008
In most developed nations big cities are expanding ever farther into the countryside. Rural populations are growing, whether with workers - commuters or the self-employed - retired people, or temporary residents. In France a "periurbanization" movement began in Ile-de-France in the 1960s and spread to the large provincial cities in the next decade before becoming a nationwide phenomenon (Le Jeannic 1997; Schmitt et al. 1998; Cavailhès and Schmitt 2002). So successful was this movement that by 1999 33% of the land area of France was periurban with 12.3 million people living there. Progression from 1990 to 1999 was remarkable, with the area concerned increasing by half (more than 6 million he…
Guide pour l'ergonomie des interfaces homme-machine
1998
Rapport de contrat Bull INRIA; Spécifications ergonomiques pour la conception des interfaces logicielles Bull
Family and values in three novels by Almudena Grandes : Malena es un nombre de tango, Los aires difíciles and El corazón helado
2017
Family has always inspired great novels which often highlight the relationship between the different generations. The subject of family is indeed constantly reinvested by authors regardless of their nationality or the period they depict. Almudena Grandes belongs to such category of writers and gives a paramount role to the family unit. Although a recurring topic in her literary trajectory, it has never been thoroughly studied by critics who yet analyzed many aspects of her work. Because such topic seemed crucial to us in Grandes’s writing, we focused on the family unit in three of her novels, Malena es un nombre de tango, Los aires difíciles and El corazón helado. In our corpus, family is, …