Search results for "Models"

Anesthesia for Euthanasia Influences mRNA Expression in Healthy Mice and after Traumatic Brain Injury

2014

Tissue sampling for gene expression analysis is usually performed under general anesthesia. Anesthetics are known to modulate hemodynamics, receptor-mediated signaling cascades, and outcome parameters. The present study determined the influence of anesthetic paradigms typically used for euthanization and tissue sampling on cerebral mRNA expression in mice. Naïve mice and animals with acute traumatic brain injury induced by controlled cortical impact (CCI) were randomized to the following euthanasia protocols (n=10-11/group): no anesthesia (NA), 1 min of 4 vol% isoflurane in room air (ISO), 3 min of a combination of 5 mg/kg midazolam, 0.05 mg/kg fentanyl, and 0.5 mg/kg medetomidine intraperi…

Does autoimmunity play a part in the pathogenesis of glaucoma?

2013

Glaucoma is a chronic neurodegenerative disease and one of the leading causes of blindness. Several risk factors have been described, e.g. an elevated intraocular pressure (IOP), oxidative stress or mitochondrial dysfunction. Additionally, alterations in serum antibody profiles of glaucoma patients, upregulation (e.g. anti-HSP60, anti-MBP) and downregulation (e.g. anti-14-3-3), have been described, but it still remains elusive if the autoantibodies seen in glaucoma are an epiphenomenon or causative. However, it is known that elicited autoimmunity causes retinal ganglion cell loss resulting in glaucomatous-like damage and according to the autoaggressive nature of some autoantibodies we found…

Analyzing the metrics of the perceptual space in a new multistage physiological colour vision model

2009

In this work, the metric of a new multistage colour vision model, ATTD05, is assessed and a new colour difference formula is suggested. Firstly, the uniformity of the ATTD05 colour space was compared with that of CIECAM02 for some Munsell samples, because if the model yields a uniform perceptual space, we will be able to implement a colour difference formula as a Euclidian distance between two points. Secondly, we developed a new space based on the perceptual descriptors of the model: brightness, hue, colourfulness, and saturation. After that, we calculated the free parameters of the space that better fit the measured and experimental data of two datasets (small-magnitude and large-magnitud…

An adaptive probabilistic approach to goal-level imitation learning

2010

Imitation learning has been recognized as a promising technique to teach robots advanced skills. It is based on the idea that robots could learn new behaviors by observing and imitating the behaviors of other skilled actors. We propose an adaptive probabilistic graphical model which copes with three core issues of any imitative behavior: observation, representation and reproduction of skills. Our model, Growing Hierarchical Dynamic Bayesian Network (GHDBN), is hierarchical (i.e. able to characterize structured behaviors at different levels of abstraction), and growing (i.e. skills are learned or updated incrementally - and at each level of abstraction - every time a new observation sequence…

Cognitive Reasoning and Inferences through Psychologically based Personalised Modelling of Emotions Using Associative Classifiers

2014

The development of Microsoft Kinect opened up the research field of computational emotions to a wide range of applications, such as learning environments, which are excellent candidates to trial computational emotions based algorithms but were never feasible for given consumer technologies. Whilst Kinect is accessible and affordable technology it comes with its' own additional challenges such as the limited number of extracted Action Units (AUs). This paper presents a new approach that attempts at finding patterns of interaction between AUs and each other on one hand and patterns that link the related AUs to a given emotion. In doing so, this paper presents the ground work necessary to reac…

Understanding TwitterTM Use among Parliament Representatives: A Genre Analysis

2011

Published version of a chapter published in the book: Electronic Participation. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-23333-3_1 This article examines parliament representatives’ Twitter- contributions (tweets). First, the genre of communication approach is introduced to identify common characteristics and communication patterns. Second, the findings are analysed using various eDemocracy models and deliberative standards to identify to what extent these tweets could be characterized as part of a deliberative discussion. The tweets are mainly dominated by five communication purposes; providing links to information sources for other Twitter users, to inform …

Air pollution, chronic smoking, and mortality.

2019

Revenue models in cloud computing

2012

Cloud computing brings new possibilities, allowing software firms to sell their software products using the Software-as-a-Service (SaaS) model. SaaS provides opportunities for flexible pricing but creates challenges on how to achieve a profitable revenue stream. In this multicase study, the revenue models of five SaaS providers were examined. The main interest of the study was to investigate the different revenue models and the reasons for using particular revenue models. The revenue models were found to be mainly based on software renting, with a variety of pricing strategies. For SaaS providers, software renting generates a steady and predictable stream of revenue. The software renting mo…

Transformation of Loyalty to E-loyalty

2020

As everyday life moves to the Internet, many factors and components have come up, with the "e" and e-loyalty not an exception. The authors focused on the transformation of loyalty to e-loyalty. It is important to understand the main differences between consumer loyalty models and e-loyalty models in order to promote business development not only in the traditional environment but also in the online environment. Such research methods as comparative analysis, analysis of the scientific literature, content analysis were used. The main focus of the research was on comparing loyalty models in the traditional and e-environment to find out the peculiarities and main features of the e-environment. …

Modeling of 137Cs migration in soils using an 80-year soil archive: role of fertilizers and agricultural amendments

2008

An 80-year soil archive, the 42-plot experimental design at the INRA in Versailles (France), is used here to study long-term contamination by 137Cs atmospheric deposition and the fate of this radioisotope when associated with various agricultural practices: fallow land, KCl, NH4(NO3), superphosphate fertilizers, horse manure and lime amendments. The pertinence of a simple box model, where radiocaesium is supposed to move downward by convectional mechanisms, is checked using samples from control plots which had been neither amended, nor cultivated since 1928. This simple model presents the advantage of depending on only two parameters: α, a proportional factor allowing the historical atmosph…