Search results for "Models"
showing 10 items of 8211 documents
Mobilités étudiantes et territoires universitaires :vers une uniformisation des pratiques ?
2005
Since French Society enters the so-called “Economy of knowledge”, migrations of young people, especially these concerning students, are of most interests. Despite the fact that it could help to understand University as a system and ways regions can evolve, the study of students' migrations was not yet done. A set of results highlights first the main role of French capital region. It shows also main changes in migrations of students following vocational training in University. At least, it reveals that architectures of students' migrations look like these of migrations of the whole French population.
Współpraca i partnerstwo : teoretyczne modele relacji organizacji pozarządowych z jednostkami administracji publicznej
2018
Theoretical nmdels were constructed to present and analyse relationships between public administration and non-governrnenlal organizations, cven ifthey difter in terins of central categories, usually point to the symmelry of the posiLion of the parties as the basis for the ąuality of relations between tliem. 'Ihe suggested form is partner ship; that is, co-operation where actors are cqual and as such, despite differences in resóurccs and compclences, tltey share fairly rights-, obligations and responsibility in the process of creating and implemenling social policies. This cąuality is the conscąuence of inereasing the capacity of non governmental organizations to participatc in this field, …
Jet fragmentation transverse momentum distributions in pp and p-Pb collisions at √s, √sNN = 5.02 TeV
2021
Jet fragmentation transverse momentum (jT) distributions are measured in proton-proton (pp) and proton-lead (p-Pb) collisions at √sNN = 5.02 TeV with the ALICE experiment at the LHC. Jets are reconstructed with the ALICE tracking detectors and electromagnetic calorimeter using the anti-kT algorithm with resolution parameter R = 0.4 in the pseudorapidity range |η| < 0.25. The jT values are calculated for charged particles inside a fixed cone with a radius R = 0.4 around the reconstructed jet axis. The measured jT distributions are compared with a variety of parton-shower models. Herwig and Pythia 8 based models describe the data well for the higher jT region, while they underestimate the low…
The genome sequence of Blochmannia floridanus: Comparative analysis of reduced genomes
2003
Bacterial symbioses are widespread among insects, probably being one of the key factors of their evolutionary success. We present the complete genome sequence of Blochmannia floridanus , the primary endosymbiont of carpenter ants. Although these ants feed on a complex diet, this symbiosis very likely has a nutritional basis: Blochmannia is able to supply nitrogen and sulfur compounds to the host while it takes advantage of the host metabolic machinery. Remarkably, these bacteria lack all known genes involved in replication initiation ( dna A, pri A, and rec A). The phylogenetic analysis of a set of conserved protein-coding genes shows that Bl. floridanus is phylogenetically related to Buch…
Revisiting the “The Breakfast Club”: Testing Different Theoretical Models of Belongingness and Acceptance (and Social Self-Representation)
2021
The current work tests different theoretical models of belongingness and acceptance as fundamental needs for human motivation. In the current study, 372 participants were presented with 52 different items measuring five different theoretical models of belongingness (with a total of 32 items) and three different theoretical models of acceptance (with a total of 20 items). In a first step, Confirmatory Factor Analysis (CFA) failed to provide support for these eight theoretical models. In a second step, we therefore applied Exploratory Factor Analysis yielding three factors, which we interpreted as communicating: (1) Belongingness, (2) Emotion-Acceptance, and (3) Social Self-Representation. In…
ESTIMATION OF ATTRIBUTE IMPORTANCE BY CHOICE TIME IN A RANKING TASK
2010
The evaluation of the quality of products and services as a function of their attributes has been broadly implemented in marketing research. The current methods for identifying important attributes and prioritize them suffer from theoretical and practical limitations. The former are related to the choice of the most appropriate model for the specific experimental context, the latter are due to the large amount of variables (cognitive, context and survey variables) affecting the chosen model. This work aims at presenting a new method for capturing consumer attribute preferences and estimating the relative importance weights by using the choice time in a ranking task. All is made through an e…
Good clinical response, remission, and predictors of remission in rheumatoid arthritis patients treated with tumor necrosis factor-α blockers: The GI…
2007
OBJECTIVE: To assess the prevalence of good clinical response and remission in rheumatoid arthritis (RA) patients with longstanding disease treated with anti-tumor necrosis factor-alpha (TNF-alpha) drugs at outpatient clinics. METHODS: Retrospective national study of 14 academic tertiary referral rheumatology medical centers. RA patients with a Disease Activity Score (DAS28) > 3.2 were defined as having active disease and could start TNF-alpha blockers. All patients received one TNF-alpha blocker plus methotrexate (10-20 mg/wk). At the third month the patients were categorized as responders or nonresponders, based on improvement of at least 0.25 of the Health Assessment Questionnaire (HAQ).…
Targeting the mevalonate pathway for improved anticancer therapy.
2009
The mevalonate pathway is important for the generation of isoprene moieties thereby providing the basis for the biosynthesis of molecules required for maintaining membrane integrity, steroid production and cell respiration. Additionally, isoprene precursors are indispensable for the prenylation of regulatory proteins such as Ras and Ras-homologous (Rho) GTPases. These low molecular GTP-binding proteins play key roles in numerous signal transduction pathways stimulated upon activation of cell surface receptors by ligand binding. Thus, Ras/Rho proteins eventually regulate cell proliferation, tumor progression and cell death induced by anticancer therapeutics. Lipid modification of Ras/Rho pro…
A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo
2015
AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…
Nitrate and nitrite in the diet: How to assess their benefit and risk for human health
2015
Nitrate is a natural constituent of the human diet and an approved food additive. It can be partially converted to nitrogen monoxide, which induces vasodilation and thereby decreases blood pressure. This effect is associated with a reduced risk regarding cardiovascular disease, myocardial infarction, and stroke. Moreover, dietary nitrate has been associated with beneficial effects in patients with gastric ulcer, renal failure, or metabolic syndrome. Recent studies indicate that such beneficial health effects due to dietary nitrate may be achievable at intake levels resulting from the daily consumption of nitrate-rich vegetables. N-nitroso compounds are endogenously formed in humans. However…