Search results for "Modern"
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Ancient bacterial genomes reveal a high diversity of Treponema pallidum Strains in early Modern Europe
2020
Syphilis is a globally re-emerging disease, which has marked European history with a devastating epidemic at the end of the 15th century. Together with non-venereal treponemal diseases, like bejel and yaws, which are found today in subtropical and tropical regions, it currently poses a substantial health threat worldwide. The origins and spread of treponemal diseases remain unresolved, including syphilis’ potential introduction into Europe from the Americas. Here, we present the first genetic data from archaeological human remains reflecting a high diversity of Treponema pallidum in early modern Europe. Our study demonstrates that a variety of strains related to both venereal syphilis and y…
Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?
2020
Cancers are one of the major challenges faced by modern medicine both because of their impact in terms of the amount of cases and of the ineffectiveness of therapies used today. A concrete support to the fight against them can be found in the analysis and understanding of the molecular mechanisms involving molecular chaperones. In particular, HSP60 and HSP10 seem to play an important role in carcinogenesis, supporting tumours in their proliferation, survival, and metastasis. Efforts must be directed toward finding ways to eliminate or block this “mistaken” chaperone. Therefore, the scientific community must develop therapeutic strategies that consider HSP60 and HSP10 as the possible target …
Immunmodulatory and Antiproliferative Properties of Rhodiola Species.
2016
The traditional medicines of Asia and Europe have long used various Rhodiola species, which are endemic to the subarctic areas of the northern hemisphere, as tonic, adaptogen, antidepressant, and anti-inflammatory drugs. In order to establish the therapeutic uses of these plants in modern medicine, the pharmacological effects of Rhodiola sp. have been widely studied. Indeed, the most amply researched species, Rhodiola rosea, has been shown to possess antioxidant, adaptogenic, antistress, antimicrobial, immunomodulatory, angiomodulatory, and antitumoral effects. Salidroside (p-hydroxyphenethyl-β-D-glucoside), a major compound in Rhodiola, seems to be responsible for many of the effects obser…
COVID-19: unravelling the clinical progression of nature’s virtually perfect biological weapon
2020
Coronavirus disease 2019 (COVID-19) pandemic has shocked the world and caused morbidity and mortality on an unprecedented level in the era of modern medicine. Evidence generated to-date on the virulence and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suggests that COVID-19 may be considered a perfect storm, caused by a nature’s virtually perfect biological weapon. This conclusion is supported by an updated analysis of pathogenesis and clinical progression of this infectious disease. It is now readily apparent that COVID-19 is not a clear-cut disorder, but is instead a gradually evolving pathology, characterized by a series of stages sustained by different m…
Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives
2020
Background: Early and accurate diagnosis of endometriosis is crucial for the management of this benign, yet debilitating pathology. Despite the advances of modern medicine, there is no common ground regarding the pathophysiology of this disease as it continues to affect the quality of life of millions of women of reproductive age. The lack of specific symptoms often determines a belated diagnosis. The gold standard remains invasive, surgery followed by a histopathological exam. A biomarker or a panel of biomarkers is easy to measure, usually noninvasive, and could benefit the clinician in both diagnosing and monitoring the treatment response. Several studies have advanced the idea of biomar…
Ancient bacterial genomes reveal a formerly unknown diversity ofTreponema pallidumstrains in early modern Europe
2020
SummarySexually transmitted (venereal) syphilis marked European history with a devastating epidemic at the end of the 15thcentury, and is currently re-emerging globally. Together with non-venereal treponemal diseases, like bejel and yaws, found in subtropical and tropical regions, it poses a prevailing health threat worldwide. The origins and spread of treponemal diseases remain unresolved, including syphilis’ potential introduction into Europe from the Americas. Here, we present the first genetic data from archaeological human remains reflecting a previously unknown diversity ofTreponema pallidumin historical Europe. Our study demonstrates that a variety of strains related to both venereal…
Coffins in Finland : the history of production, design and attitudes
2017
AbstractCoffins as death-related objects have changed in Finland during the past 150 years and the Finnish funeral industry has been created to answer the changing needs of customers. No longer do people build coffins in the household, or only buy a coffin and some other items from the funeral company: now professionals manage entire funerals. Coffin designs have become simpler and less socially discriminating and the colour formerly reserved for children and young people, white, has become the most popular colour for a coffin. Attitudes towards coffins have also changed, from mild dislike of having a coffin in the home to general demand of hiding coffins even in funeral companies’ premises…
‘Each flight is different’ : Carbon emissions of selected flights in three geographical markets
2017
Abstract Air travel is considered the biggest individual climate sin. Avoiding flying, however, seems impossible. In this paper we argue that the flight a passenger chooses can be significant. For this purpose we compared the carbon emissions of selected flights in three geographical markets. We found tremendous differences in the environmental performance of individual flights. Furthermore, we also found that flying with the most modern aircraft or flying non-stop represents, in many cases, the least polluting option. Nevertheless, we were able to show that there are exceptions to this rule. Based on our results, we provide recommendations to the industry and for further research.
Language Policy and Ethnic Tensions in Quebec and Latvia
2004
Introduction Concern for the French language in Quebec in the 1960s and 1970s and the Latvian language in the then Soviet Union in the late 1980s and in the new Latvian state in the 1990s were ignited by some of the same demographic and assimilative forces in the two societies. Both Quebec and Latvia had lost their independence to larger powers. The birth rate and population declined abruptly in the two subnations. Schools in English (in Quebec) and Russian (in Latvia) attracted most immigrants. The elites were disproportionately drawn from outside the majority ethnic groups. To counter these trends, language policies were drafted, restricting access to English and Russian languages in scho…
Professionalization as Status Adaptation: The Nobility, the Bureaucracy, and the Modernization of the Legal Profession in Finland
1991
In contrast to Anglo-American lines of professional development, the central agent of professionalization in many Continental countries was the state bureaucracy. However, this article proposes that an understanding of the class structure of traditional society is also needed to explain the privileged position of lawyers. An historical study of lawyers in the 19th century, after Finland was annexed by Russia, demonstrates that the legal profession provided the nobility an important medium of adaptation to the new society. The importance of the legal profession initially to the state bureaucracy, and subsequently to the nobility, explains its social prominence and its future development. An …