Search results for "Modula"

showing 10 items of 1481 documents

Vector FWM in optical fibers: tuning techniques and applications

2022

Recientemente, el efecto no lineal de mezcla de cuatro ondas (FWM) en fibras ópticas ha atraído un gran interés para el desarrollo de nuevas fuentes de luz de fibra óptica debido a la emisión de luz múltiple producida por este efecto no lineal. En los últimos años, estas fuentes de luz basadas en FWM han demostrado una gran utilidad en áreas como la óptica cuántica y la microscopía avanzada basada en efecto Raman. Además, según el estado de polarización de la luz de bombeo responsable del efecto FWM y la birrefringencia de la fibra, la luz producida por FWM puede presentar diferentes propiedades de polarización dada la naturaleza vectorial de FWM. Esto posibilita el diseño y desarrollo de f…

:FÍSICA [UNESCO]polarization modulation instabilityUNESCO::FÍSICAtunable light sourcemicrostructured optical fibersvector four-wave mixing
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Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the a…

2015

Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We evaluated the protective effects of the selective CB1 receptor agonist ACEA, the selective CB2 receptor agonist JWH133 and the fatty-acid amide-hydrolase (FAAH) inhibitor URB597, which enhances endocannabinoid receptor activity, on NPC proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. We performed immunohistochemical and stereological analyses of cells expressing the mitotic phosphorylation of his…

:Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Morphogenesis::Embryonic and Fetal Development::Organogenesis::Neurogenesis [Medical Subject Headings]CB1 receptorTubulina (proteína)Cannabinoid receptorCarbamatosEtanol:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Nuclear Proteins::Histones [Medical Subject Headings]Ventrículos lateralesSacarosaNeuronasSubgranular zone0302 clinical medicine:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Membrane Proteins::Receptors Cell Surface::Receptors G-Protein-Coupled::Receptors Cannabinoid::Receptor Cannabinoid CB1 [Medical Subject Headings]Histonas:Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids Acyclic::Carbamates [Medical Subject Headings]Receptor cannabinoide CB1Cannabinoid receptor type 2:Organisms::Eukaryota::Animals [Medical Subject Headings]:Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation [Medical Subject Headings]:Anatomy::Cells::Stem Cells::Neural Stem Cells [Medical Subject Headings]:Anatomy::Nervous System::Neurons [Medical Subject Headings]health care economics and organizations:Anatomy::Nervous System::Central Nervous System::Brain::Cerebral Ventricles::Lateral Ventricles [Medical Subject Headings]Original Research:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleosides::Deoxyribonucleosides::Deoxyuridine::Bromodeoxyuridine [Medical Subject Headings]0303 health sciencesAlcoholismoalcoholConsumo de alcoholNeurogenesis:Phenomena and Processes::Genetic Phenomena::Phenotype::Genetic Markers [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Cannabinoid Receptor Modulators::Cannabinoid Receptor Agonists [Medical Subject Headings]Benzamidas:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Membrane Proteins::Receptors Cell Surface::Receptors G-Protein-Coupled::Receptors Cannabinoid::Receptor Cannabinoid CB2 [Medical Subject Headings]Endocannabinoid system3. Good healthbromodesoxiuridinaneurogenesisEndocannabinoidesmedicine.anatomical_structure:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases [Medical Subject Headings]ACEADietaAlcoholFosforilaciónAgonistmedicine.medical_specialtyHidrolasasmedicine.drug_classNeurogenesiseducation:Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders::Alcohol-Related Disorders::Alcoholism [Medical Subject Headings]Subventricular zoneBiology:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings]:Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Cerebral Cortex::Hippocampus::Dentate Gyrus [Medical Subject Headings]lcsh:RC321-57103 medical and health sciencesCellular and Molecular NeuroscienceRatasInternal medicine:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Nerve Tissue Proteins::Tubulin [Medical Subject Headings]JWH133medicineGiro dentadolcsh:Neurosciences. Biological psychiatry. Neuropsychiatry030304 developmental biologyCélulas madre nerviosas:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids [Medical Subject Headings]Dentate gyrusmarcadores genéticosCB2 receptor:Chemicals and Drugs::Carbohydrates::Polysaccharides::Oligosaccharides::Disaccharides::Sucrose [Medical Subject Headings]:Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Diencephalon::Hypothalamus [Medical Subject Headings]:Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanol [Medical Subject Headings]Endocrinology:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings]nervous system:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking [Medical Subject Headings]:Chemicals and Drugs::Organic Chemicals::Amides::Benzamides [Medical Subject Headings]030217 neurology & neurosurgeryHipotálamoNeuroscience
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Strategies to gain novel Alzheimer’s disease diagnostics and therapeutics using modulators of ABCA transporters

2021

Adenosine-triphosphate-(ATP)-binding cassette (ABC) transport proteins are ubiquitously present membrane-bound efflux pumps that distribute endo- and xenobiotics across intra- and intercellular barriers. Discovered over 40 years ago, ABC transporters have been identified as key players in various human diseases, such as multidrug-resistant cancer and atherosclerosis, but also neurodegenerative diseases, such as Alzheimer���s disease (AD). Most prominent and well-studied are ABCB1, ABCC1, and ABCG2, not only due to their contribution to the multidrug resistance (MDR) phenotype in cancer, but also due to their contribution to AD. However, our understanding of other ABC transporters is limited…

ABCG2 (BCRP)Multitarget inhibitor (PANABC)Broad-spectrum modulatorPolypharmacologyActivationNeurosciences. Biological psychiatry. NeuropsychiatryAmyloid-beta (Aβ / Abeta)ABCA2ABCA5ArticleABCA7InductionABCB1 (P-gp)Pattern analysisDownregulationPET Tracer (PETABC)ABC transporterABCA1 (ABC1)Rational drug design and developmentAlzheimer’s diseaseRC321-571ABCC1 (MRP1)InhibitionFree neuropathology
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Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristal…

2007

Cannabinoid-1 (CB1) receptor activation affects gastrointestinal propulsion in vivo. It was our aim to further characterize the involved myenteric mechanisms in vivo and in vitro. In CB1(-/-) mice and wild-type littermates we performed in vivo transit experiments by charcoal feeding and in vitro electrophysiological recordings in mouse small intestinal smooth muscle. Ascending neuronal contraction (ANC) following electrical field stimulation was studied in rat ileum in a partitioned organ bath separating the aboral stimulation site from the oral recording site. The knockout animals displayed an accelerated upper gastrointestinal transit compared to control animals. The CB1 receptor antagoni…

AM251Malemedicine.medical_specialtyCannabinoid receptorPhysiologyPolyunsaturated Alkamidesmedicine.medical_treatmentNeuromuscular JunctionMotilityStimulationArachidonic AcidsBiologyNeuromuscular junctionMembrane PotentialsMiceOrgan Culture TechniquesPiperidinesReceptor Cannabinoid CB1Internal medicineCannabinoid Receptor ModulatorsReflexmedicineAnimalsRNA MessengerIntestinal MucosaRats WistarReceptorMice KnockoutMyoelectric Complex MigratingEndocrine and Autonomic SystemsReverse Transcriptase Polymerase Chain ReactionGastroenterologyMuscle SmoothEndocannabinoid systemElectric StimulationRatsIntestinesEndocrinologymedicine.anatomical_structurePyrazolesPeristalsisCannabinoidmedicine.drugEndocannabinoidsNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
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Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

Graphical abstract

ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
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The neuroinflammation collection: a vision for expanding neuro-immune crosstalk in Brain

2021

AcademicSubjects/SCI01870Neuroimmunomodulationbusiness.industryBrainCrosstalk (biology)Immune systemSpecial CommentaryAnimalsHumansMedicineAcademicSubjects/MED00310Neurology (clinical)businessNeuroscienceNeuroinflammationBrain
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Addictive-like behaviour for Acetaldehyde: involvement of D2 receptors

2013

Acetaldehyde (ACD), ethanol's first metabolite, is centrally active and shows rewarding and motivational properties. It is able to activate mesolimbic dopamine system, since it enhances neuronal firing of dopamine cells in ventral tegmental area and exerts dopamine release in the nucleus accumbens (Foddai et al., 2004; Melis et al., 2007; Deehan et al., 2013). ACD motivational properties are demonstrated by self-administration studies in rodents (Rodd et al., 2005), particularly behavioural evidence suggests that ACD could produce positive reinforcing effects in operant-conflict paradigms (Cacace et al., 2012). In order to shed light on neurobiological substrate underpinning ACD-related beh…

Acetaldehyde Dopamine system Quinpirole Ropinirole D2 D2-autoreceptors modulation
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Q-switching of an all-fiber ring laser based on in-fiber acousto-optic bandpass modulator2017

2017

Active Q-switching of an all-fiber ring laser utilizing a novel in-fiber acousto-optic tunable bandpass filter (AOTBF) is reported. The transmission characteristics of the AOTBF are controlled by amplitude modulation of the acoustic wave; the device exhibits a 3-dB power insertion loss, 0.91-nm optical bandwidth, and 28-dB nonresonant light suppression. Cavity loss modulation is achieved by full acousto-optic mode re-coupling cycle induced by traveling flexural acoustic waves. When the acoustical signal is switched on, cavity losses are reduced, and then, laser emission is generated. In addition, by varying the acoustic wave frequency, a wide wavelength tuning range of 30.7 nm is achieved f…

Acousto-optic modulationAcousto-optic filters:FÍSICA::Óptica ::Fibras ópticas [UNESCO]Fiber opticsBandpass filtersUNESCO::FÍSICA::Óptica ::Fibras ópticasFiber Lasers
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Is the nonREM–REM sleep cycle reset by forced awakenings from REM sleep?

2002

In selective REM sleep deprivation (SRSD), the occurrence of stage REM is repeatedly interrupted by short awakenings. Typically, the interventions aggregate in clusters resembling the REM episodes in undisturbed sleep. This salient phenomenon can easily be explained if the nonREM–REM sleep process is continued during the periods of forced wakefulness. However, earlier studies have alternatively suggested that awakenings from sleep might rather discontinue and reset the ultradian process. Theoretically, the two explanations predict a different distribution of REM episode duration. We evaluated 117 SRSD treatment nights recorded from 14 depressive inpatients receiving low dosages of Trimipram…

Activity CyclesMaleSelective REM sleep deprivationPolysomnographyAudiologyBehavioral NeuroscienceNIGHTSleep onset REM episodeDEPRIVATIONSlow-wave sleepmedia_commonDEPRESSIVE PATIENTSmedicine.diagnostic_testDepressionmusculoskeletal neural and ocular physiologyTRIMIPRAMINEMiddle AgedAntidepressive AgentsAnesthesiaLATENCIESFemaleWakefulnessArousalPsychologyAlgorithmspsychological phenomena and processesmedicine.drugVigilance (psychology)Adultmedicine.medical_specialtyREM episodePolysomnographymedia_common.quotation_subjectRapid eye movement sleepSleep REMExperimental and Cognitive PsychologyNon-rapid eye movement sleepmental disordersmedicineHumansWakefulnessMODULATIONUltradian rhythmINTERRUPTIONARTIFICIAL NEURAL NETWORKSRECOGNITIONTrimipramineUltradian processSleep cycleSleepEYE-MOVEMENT SLEEPPhysiology & Behavior
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Mesenchymal stem cells of Systemic Sclerosis patients, derived from different sources, show a profibrotic microRNA profiling

2019

AbstractSystemic Sclerosis (SSc) is a disease with limited therapeutic possibilities. Mesenchymal stem cells (MSCs)-therapy could be a promising therapeutic option, however the ideal MSCs source has not yet been found. To address this problem, we perform comparison between bone marrow (BM)-MSCs and adipose (A)-MSCs, by the miRs expression profile, to identify the gene modulation in these two MSCs source. MicroRNAs (miRs) are RNAs sequences, regulating gene expression and MSCs, derived from different tissues, may differently respond to the SSc microenvironment. The miRs array was used for the miRs profiling and by DIANA-mirPath tool we identified the biological functions of the dysregulated …

Adult0301 basic medicineTherapeutic gene modulationAutoimmune diseasesCellular differentiationGene regulatory networklcsh:MedicineBone Marrow CellsBiologyRegenerative medicineArticle03 medical and health sciences0302 clinical medicinemicroRNAmedicineHumansGene Regulatory Networkslcsh:ScienceCells CulturedSystemic SclerosiCell ProliferationRegulation of gene expressionScleroderma SystemicMultidisciplinarySequence Analysis RNAGene Expression ProfilingMesenchymal stem celllcsh:RCell DifferentiationMesenchymal Stem CellsSettore MED/16 - ReumatologiaMicroRNAs030104 developmental biologymedicine.anatomical_structureAdipose TissueGene Expression RegulationCancer researchSystemic sclerosisFemalelcsh:QBone marrow030217 neurology & neurosurgeryScientific Reports
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