Search results for "Modula"

Process Modeling and Planning for Robotic Cold Spray Based Additive Manufacturing

2020

Cold spray (CS) is a solid-state coating deposition technology that has recently been applied as an additive manufacturing (AM) process to fabricate individual components. This potential AM process is attracting more and more attention because of its advantages: high-forming efficiency, low temperature, and no phase changing of materials. These advantages make CS able to form large-volume objects to become an efficient and effective AM process. Nowadays, new advances in cold spray additive manufacturing (CSAM) call for new process implementation to improve the manufacturing accuracy and flexibility. Therefore, the purpose of this study is to enhance CS-based AM through the modeling and plan…

Novel Immunomodulatory Markers Expressed by Human WJ-MSC: an Updated Review in Regenerative and Reparative Medicine.

2012

Mesenchymal (stromal) stem cells (MSC) are a broad class of stromal populations which are able to differentiate towards mature cell types, and do express molecules involved in immune modulation, tolerance induction and inflammation dampening. MSC can be virtually isolated from each adult organ, as well as from foetus-associated perinatal tissues. In particular, Wharton's jelly-derived MSC (WJ-MSC) bear all of these key properties, together with their ease of sourcing and lack of ethical issues. Cellular therapy is a key technique in regenerative medicine approaches, in particular for the treatment of diseases in which physiological processes of cellular repopulation are blocked by the under…

The thymus at the crossroad of neuroimmune interactions.

2006

The numerous relationships existing between the nervous and the immune systems suggest that the neural networks present in the intrathymic microenvironment may influence T-cell development. We previously reported that thymic neural-crest-derived stromal cells are involved in a neural differentiation pathway and are able to produce neurotrophic factors and neurokines that are in turn able to increase and/or modulate thymic-stromal cell neuronal phenotype. We also showed that EGF promotes a neural phenotype in thymic epithelial cells by enhancing the expression of neuronal-specific markers, neurotransmitters, and neuropoietic cytokines, such as IL-6 and CNTF. More recently we showed that the …

2015

Abstract. The coupling of Earth system model components, which work on different grids, into an Earth System Model (ESM) provokes the necessity to transfer data from one grid to another. Additionally, each of these model components might require data import onto its specific grid. Usually, one of two approaches is used: Either all input data is preprocessed to the employed grid, or the imported data is interpolated on-line, i.e. during model integration to the required grid. For the former, each change in the model resolution requires the re-preprocessing of all data. The latter option implies that in each model integration computing time is required for the grid mapping. If all components …

The integration of information technologies in the knowledge based organizations

2016

Relations between the users' expertise, complexity of tasks to be solved by knowledge-based organizations and mission of smart information systems, is a multi-dimensional structure that should provide the necessary conceptual framework of sustainable integrated smart development. The users of smart information systems face a variety of problems, such as: system access, data recovery, identifying and retrieving a specific document and its contents, and difficulties associated with understanding and interpreting of the used system on stages and methods following to be used, respectively problems on understanding the meaning of information provided. Using smart information systems and smart da…

Using Cloud, Modularity, and Make-to-Upgrade Strategy for Integrating Customized-Oriented Supply Networks

2013

In the current global business individual demand play crucial roles. Customized-oriented supply networks are being proliferated in manufacturing industries, yet integration of their members is still quite challenging. As a practical solution, in this paper a new collaborative approach out of modularity structure, cloud computing, and a novel production strategy, called Make-to-Upgrade (MTU), is suggested. The complementary aspects of these techniques are highlighted and briefly explained here. MTU is as a strategy for future products with new characteristics, e.g., upgradability.

Opposing Forces of Social Attraction and Social Avoidance Drive Network Modularity

2020

SUMMARY: How interactions between individuals contribute to the emergence of complex societies is a major question in biology. Nonetheless, little remains known about how simple rules of social attraction (e.g. to information) and social avoidance (e.g. of disease) interact to shape sociality. We developed an individual-based model where individuals choose with whom to interact depending on the status of group mates (informed and/or infected). Statistical models indicate that the emergence of social structure depends on the cost/benefit trade-offs underlying the system. Critically, pressures that optimize social relationships – i.e. minimize risky connections while favouring those that maxi…

Late decaying 2-component dark matter scenario as an explanation of the AMS-02 positron excess

2016

The long standing anomaly in the positron flux as measured by the PAMELA and AMS-02 experiments could potentially be explained by dark matter (DM) annihilations. This scenario typically requires a large "boost factor" to be consistent with a thermal relic dark matter candidate produced via freeze-out. However, such an explanation is disfavored by constraints from CMB observations on energy deposition during the epoch of recombination. We discuss a scenario called late-decaying two-component dark matter (LD2DM), where the entire DM consists of two semi-degenerate species. Within this framework, the heavier species is produced as a thermal relic in the early universe and decays to the lighter…

Subgroup S-commutativity degrees of finite groups

2012

Microwave second-harmonic response of ceramic MgB2 samples

2005

Nonlinear microwave response of different ceramic MgB2 samples has been investigated by the technique of second-harmonic emission. The second-harmonic signal has been investigated as a function of temperature, DC magnetic field and input microwave power. The attention has mainly been devoted to the response at low magnetic fields, where nonlinear processes arising from motion of Abrikosov fluxons are ineffective. The results show that different mechanisms are responsible for the nonlinear response in the different ranges of temperature. At low temperatures, the nonlinear response is due to processes involving weak links. At temperatures close to Tc, a further contribution to the harmonic em…