Search results for "Modula"
showing 10 items of 1481 documents
Preclinical characterization of antagomiR-218 as a potential treatment for myotonic dystrophy
2021
Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease caused by expansion of unstable CTG repeats in a non-coding region of the DMPK gene. CUG expansions in mutant DMPK transcripts sequester MBNL1 proteins in ribonuclear foci. Depletion of this protein is a primary contributor to disease symptoms such as muscle weakness and atrophy and myotonia, yet upregulation of endogenous MBNL1 levels may compensate for this sequestration. Having previously demonstrated that antisense oligonucleotides against miR-218 boost MBNL1 expression and rescue phenotypes in disease models, here we provide preclinical characterization of an antagomiR-218 molecule using the HSALR mouse model and patient-d…
A classification of $\protect \mathbb{R}$-Fuchsian subgroups of Picard modular groups
2018
Conditioned Pain Modulation Is Not Impaired in Individuals with Frozen Shoulder: A Case-Control Study
2021
Frozen shoulder (FS) is a poorly understood condition resulting in substantial shoulder pain and mobility deficits. The mechanisms behind FS are not yet fully understood, but, similar to other persistent pain states, central pain mechanisms may contribute to ongoing symptoms in this population. The objective of this research was to investigate conditioned pain modulation (CPM) in people with FS compared with pain-free individuals. A total of 64 individuals with FS and 64 healthy volunteers participated in this cross-sectional study. CPM was assessed by using the pressure pain threshold (PPT) and an occlusion cuff (tourniquet test) as the test and conditioning stimulus, respectively. The abs…
Autophagy
2012
Klionsky, Daniel J. et al.
New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the HIBEAM/NNBAR experiment at the European Spalla…
2021
Abstract The violation of baryon number, B , is an essential ingredient for the preferential creation of matter over antimatter needed to account for the observed baryon asymmetry in the Universe. However, such a process has yet to be experimentally observed. The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source to search for baryon number violation. The program will include high-sensitivity searches for processes that violate baryon number by one or two units: free neutron–antineutron oscillation ( n → n ̄ ) via mixing, neutron–antineutron oscillation via regeneration from a sterile neutron state ( n → [ n ′ , n ̄ ′ ] → n ̄ ), and neutron disappearan…
All-sky search in early O3 LIGO data for continuous gravitational-wave signals from unknown neutron stars in binary systems
2021
Rapidly spinning neutron stars are promising sources of continuous gravitational waves. Detecting such a signal would allow probing of the physical properties of matter under extreme conditions. A significant fraction of the known pulsar population belongs to binary systems. Searching for unknown neutron stars in binary systems requires specialized algorithms to address unknown orbital frequency modulations. We present a search for continuous gravitational waves emitted by neutron stars in binary systems in early data from the third observing run of the Advanced LIGO and Advanced Virgo detectors using the semicoherent, GPU-accelerated, binaryskyhough pipeline. The search analyzes the most s…
Major Histocompatibility Complex Modulation and Loss
2002
Photobiomodulation Therapy in the Management of Burning Mouth Syndrome: Morphological Variations in the Capillary Bed
2020
Burning mouth syndrome (BMS) is an idiopathic condition that manifests itself primarily with the onset of a burning sensation. The aim of this research was to perform photobiomodulation therapy (PBM) using a diode laser on the oral mucosa of BMS patients, followed by an objective evaluation of the morphological changes in the vascular bed underlying the mucosa using polarized light videocapillaroscopy. A group of 40 patients were included in the study. The patients were randomly divided into two groups (using simple randomization) as follows: 20 patients were assigned to the laser group and 20 patients were assigned to the placebo group. Each patient of the laser group received eight irradi…
Lau Effect And Binary Logic
1989
The Lau effect is applied to implement the whole set of binary logic operations optically. Our technique works with spatially incoherent light and does not require lenses or any other optical accessory.
Novel Three-Phase Multilevel Inverter With Reduced Components for Low- and High-Voltage Applications
2021
In this article, a novel multilevel topology for three-phase applications, having three-level and hybrid N -level modular configurations, enabling low-, medium-, and high-voltage operations, is presented. The proposed topology has several attractive features, namely reduced component count, being capacitor-, inductor-, and diode-free, lowering cost, control-complexity, and size, and can operate in a wide range of voltages and powers. Selected simulation and experimental results are presented to verify the performance of the proposed topology. Further, the overall efficiency of the topology and loss distribution in switches are studied. Finally, the key features of the proposed topology in t…