Search results for "Modula"

Chapter 9 Nicotinic acetylcholine receptors on hippocampal neurons: cell compartment-specific expression and modulatory control of channel activity

1996

Publisher Summary The neuronal nicotinic acetylcholine receptors (nAChRs) are differentially expressed on the somato-dendritic surface of hippocampal neurons. This chapter demonstrates that various ions and drugs play a crucial role in modulating the activity of neuronal nAChRs. Considering the diversity of the neurotransmitter receptors and their binding sites and the diversity of substances, which can act simultaneously as a primary agonist of one receptor and an allosteric modulator of a different receptor, an enormous variety of combinatorial possibilities can be achieved in the brain giving rise to very complex neuronal networks. The characterization of the diversity of many receptors …

The In Vitro Pharmacological Profile Of LAS100977 - A Potent, Selective And Long-acting Beta-2 Receptor Agonist

2010

Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis

2020

Abstract Fingolimod is an approved treatment for relapsing–remitting multiple sclerosis (MS), and its properties in different pathways have raised interest in therapy research for other neurodegenerative diseases. Fingolimod is an agonist of sphingosine-1-phosphate (S1P) receptors. Its main pharmacologic effect is immunomodulation by lymphocyte homing, thereby reducing the numbers of T and B cells in circulation. Because of the ubiquitous expression of S1P receptors, other effects have also been described. Here, we review preclinical experiments evaluating the effects of treatment with fingolimod in neurodegenerative diseases other than MS, such as Alzheimer’s disease or epilepsy. Fingolimo…

Fibroblast Growth Factor Receptor 1– 5-Hydroxytryptamine 1A Heteroreceptor Complexes and Their Enhancement of Hippocampal Plasticity

2011

Background The hippocampus and its 5-hydroxytryptamine transmission plays an important role in depression related to its involvement in limbic circuit plasticity. Methods The analysis was made with bioluminescence resonance energy transfer, co-immunoprecipitation, in situ proximity ligation assay, binding assay, in cell western and the forced swim test. Results Using bioluminescence resonance energy transfer analysis, fibroblast growth factor receptor 1 (FGFR1)-5-hydroxytryptamine 1A (5-HT1A) receptor complexes have been demonstrated and their specificity and agonist modulation characterized. Their presence based on co-immunoprecipitation and proximity ligation assay has also been indicated…

Relative principal congruences in congruence-modular quasivarieties

1998

The problem of definability of relative principal congruences in relatively congruence modular (RCM) quasivarieties is investigated. The RCM quasivarieties are characterized in terms of parameterized families of finite sets of pairs of terms which define relative principal congruences.

Ordinary and p-modular character degrees of solvable groups

1991

Solvable groups withp-modular character degrees of prime power

1990

Representations of Certain Banach C*-modules

2004

The possibility of extending the well known Gelfand–Naimark– Segal representation of *-algebras to certain Banach C*-modules is studied. For this aim the notion of modular biweight on a Banach C*-module is introduced. For the particular class of strict pre CQ*-algebras, two different types of representations are investigated.

A remark on conjectures in modular representation theory

1987

PIP-Spaces and Signal Processing

2009

Contemporary signal processing makes an extensive use of function spaces, always with the aim of getting a precise control on smoothness and decay properties of functions. In this chapter, we will discuss several classes of such function spaces that have found interesting applications, namely, mixed-norm spaces, amalgam spaces, modulation spaces, or Besov spaces. It turns out that all those spaces come in families indexed by one or more parameters, that specify, for instance, the local behavior or the asymptotic properties. In general, a single space, taken alone, does not have an intrinsic meaning, it is the family as a whole that does, which brings us to the very topic of this volume. In …