Search results for "Modula"
showing 10 items of 1481 documents
Characters and Blocks of Finite Groups
1998
This is a clear, accessible and up-to-date exposition of modular representation theory of finite groups from a character-theoretic viewpoint. After a short review of the necessary background material, the early chapters introduce Brauer characters and blocks and develop their basic properties. The next three chapters study and prove Brauer's first, second and third main theorems in turn. These results are then applied to prove a major application of finite groups, the Glauberman Z*-theorem. Later chapters examine Brauer characters in more detail. The relationship between blocks and normal subgroups is also explored and the modular characters and blocks in p-solvable groups are discussed. Fi…
Faithful representations of left C*-modules
2010
The existence of a faithful modular representation of a left module $$ \mathfrak{X} $$ over a C*-algebra $$ \mathfrak{A}_\# $$ possessing sufficiently many traces is proved.
Examples of Indexed PIP-Spaces
2009
This chapter is devoted to a detailed analysis of various concrete examples of pip-spaces. We will explore sequence spaces, spaces of measurable functions, and spaces of analytic functions. Some cases have already been presented in Chapters 1 and 2. We will of course not repeat these discussions, except very briefly. In addition, various functional spaces are of great interest in signal processing (amalgam spaces, modulation spaces, Besov spaces, coorbit spaces). These will be studied systematically in a separate chapter (Chapter 8).
Modular quintics inℙ4
2003
We will examine the arithmetic of some of the members of a pencil of symmetric quintics in projective 4-space. We will give evidence for the modularity of some of the exceptional members (even the non-rigid ones) and give a proof in one rigid case. (© 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Regulation of IgE production and airway reactivity by CD4(-)CD8(-) regulatory T cells
2015
The mechanisms of tolerance induction occurring in the course of allergen-specific immunotherapy have not been elucidated in full detail. Our study aimed to characterize high zone tolerance in mouse models of type I allergy and of allergic airway inflammation induced by subcutaneous sensitization of mice with high doses of the model allergen ovalbumin (OVA) without the use of adjuvant. Mice were immunized by subcutaneous injection of high doses (HD) of OVA or, for comparison, low doses (LD) of OVA in saline. HD-mice showed lower specific IgE, but augmented IgG in sera than LD-mice. Pre-treatment of mice with HD-OVA antigen-specifically inhibited IgE production subsequently induced by LD-OVA…
dIvergEnt: How IgE Axis Contributes to the Continuum of Allergic Asthma and Anti-IgE Therapies
2017
[EN] Asthma is an airway disease characterised by chronic inflammation with intermittent or permanent symptoms including wheezing, shortness of breath, chest tightness, and cough, which vary in terms of their occurrence, frequency, and intensity. The most common associated feature in the airways of patients with asthma is airway inflammation. In recent decades, efforts have been made to characterise the heterogeneous clinical nature of asthma. The interest in improving the definitions of asthma phenotypes and endotypes is growing, although these classifications do not always correlate with prognosis nor are always appropriate therapeutic approaches. Attempts have been made to identify the m…
Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10
2014
The prevalence of allergic asthma and other atopic diseases has reached epidemic proportions in large parts of the developed world. The gradual loss of the human indigenous microbiota has been held responsible for this trend. The bacterial pathogen Helicobacter pylori is a constituent of the normal gastric microbiota whose presence has been inversely linked to allergy and asthma in humans and experimental models. Here we show that oral or i.p. tolerization with H. pylori extract prevents the airway hyperresponsiveness, bronchoalveolar eosinophilia, pulmonary inflammation, and Th2 cytokine production that are hallmarks of allergen-induced asthma in mice. Asthma protection is not conferred by…
El modulador alostérico negativo de los mGluR5, MPEP, potencia la reinstauración de la preferencia condicionada inducida con priming de cocaína
2019
Cocaine addiction is a chronic disorder with high relapse rates; therefore, understanding the neuronal mechanisms underlying drug-seeking during relapse is a priority to develop targeted pharmacotherapy. The metabotropic glutamate receptor 5 (mGluR5) seems to be involved in the reinstatement induced by cocaine-associated cues. The main objective of the study was to evaluate the efficacy of MPEP, a negative allosteric modulator of mGluR5, in attenuating or potentiating the reinstatement induced by priming doses of cocaine in the CPP paradigm, ultimately to further knowledge regarding the role of the mGluR5 in relapse into cocaine abuse. OF1 mice (48 female and 48 male) were conditioned in th…
Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and …
2019
Immunomodulatory glycolipids, among which α-galactosylceramide (KRN7000) is an iconic example, have shown strong therapeutic potential in a variety of conditions ranging from cancer and infection to autoimmune or neurodegenerative diseases. A main difficulty for those channels is that they often provoke a cytokine storm comprising both pro- and anti-inflammatory mediators that antagonize each other and negatively affect the immune response. The synthesis of analogues with narrower cytokine secretion-inducing capabilities is hampered by the intrinsic difficulty at controlling the stereochemical outcome in glycosidation reactions, particularly if targeting the α-anomer, which seriously hamper…