Search results for "Modula"
showing 10 items of 1481 documents
Exploring social media network landscape of post-Soviet space
2019
The “post-Soviet space” consists of countries with a substantial fraction of the world’s population; however, unlike many other regions, its social media network landscape is still somewhat under-explored. This paper aims at filling this gap. To this purpose, we use anonymized data on user friendships at VK.com (also known as VKontakte and, informally, as “Russian Facebook”), which is the largest and most popular social media portal in the post-Soviet space with hundreds of millions of user accounts. Using the VK network snapshots from October 2015 to December 2016, we conduct a “multiscale” empirical study of this network by considering conn…
Disrupting immune regulation incurs transient costs in male reproductive function.
2014
9 pages; International audience; BACKGROUND: Immune protection against pathogenic organisms has been shown to incur costs. Previous studies investigating the cost of immunity have mostly focused on the metabolic requirements of immune maintenance and activation. In addition to these metabolic costs, the immune system can induce damage to the host if the immune response is mis-targeted or over-expressed. Given its non-specific nature, an over-expressed inflammatory response is often associated with substantial damage for the host. Here, we investigated the cost of an over-expressed inflammatory response in the reproductive function of male mice. METHODOLOGY/PRINCIPAL FINDINGS: We experimenta…
Abnormal mitotic spindle assembly and cytokinesis induced by D-Limonene in cultured mammalian cells
2013
D-Limonene is found widely in citrus and many other plant species; it is a major constituent of many essential oils and is used as a solvent for commercial purposes. With the discovery of its chemotherapeutic properties against cancer, it is important to investigate the biological effects of the exposure to D-Limonene and elucidate its, as yet unknown, mechanism of action. We reported here that D-Limonene is toxic in V79 Chinese hamster cells in a dose-dependent manner. Moreover, to determine the cellular target of D-Limonene, we performed morphological observations and immunocytochemical analysis and we showed that this drug has a direct effect on dividing cells preventing assembly of mito…
Wharton’s Jelly Mesenchymal Stem Cells as Candidates for Beta Cells Regeneration: Extending the Differentiative and Immunomodulatory Benefits of Adul…
2010
Mesenchymal stem cells (MSC) are uniquely capable of crossing germinative layers borders (i.e. are able to differentiate towards ectoderm-, mesoderm- and endoderm-derived cytotypes) and are viewed as promising cells for regenerative medicine approaches in several diseases. Type I diabetes therapy should potentially benefit from such differentiated cells: the search for alternatives to organ/islet transplantation strategies via stem cells differentiation is an ongoing task, significant goals having been achieved in most experimental settings (e.g. insulin production and euglycaemia restoration), though caution is still needed to ensure safe and durable effects in vivo. MSC are obtainable in …
Effects of leflunomide on immune responses and models of inflammation.
1993
Leflunomide is an antiphlogistic and immunomodulating agent that has been shown to be effective in preventing and healing autoimmune disorders and reactions leading to organ graft rejection. From our preliminary clinical data [4], we now have hopes that these effects, observed in experimental animals, can truly be transferred to humans. Although we are far from understanding the mode of action of leflunomide, we are slowly gathering some insight. A good many of the immunosuppressive effects of leflunomide can be attributed to the antagonistic effects it has on responses to many cytokines, most likely through receptor expression and signal transduction (tyrosine kinase inhibition). The inhib…
Graphical THD minimization procedure for single phase five-level converters
2017
This paper proposes two graphycal procedure to mitigate h harmonics and to minimize the total harmonic distortion (THD), respectively. The paper considers a five-level inverter and fundamental frequency modulation: it computes the two switching angles able to reduce low order harmonics and able to minimize the THD. Simulation results are obtained and, in order to validate the proposed procedure, an experimental prototype is built and experimental results are carried out. The comparison between simulation and experimental results confirms the accuracy of the proposed graphycal procedure. It is shown that the switching angles to mitigate the third-fifth and the third-fifth-seventh harmonics e…
Neuroestimulación medular. Análisis de las indicaciones diagnósticas
2020
espanolRESUMEN Introduccion: La neuroestimulacion medular (NM) es una forma de tratamiento del dolor cronico que ha demostrado su efectividad en pacientes que han respondido mal a otras terapias. Las indicaciones actuales para los dispositivos de NM son muy variadas. El objetivo de nuestro estudio es analizar las indicaciones diagnosticas de la terapia con NM durante los ultimos 5 anos en nuestro hospital, conocer cuales son las causas de dolor mas frecuentes para la indicacion del implante del dispositivo y que porcentaje de mejoria presentan los pacientes, asi como estudiar la relacion con el genero y la edad. Material y metodos: Se trata de un estudio observacional, descriptivo y retrosp…
Contribution of exclusive diffractive processes to the measured azimuthal asymmetries in SIDIS
2019
Hadron leptoproduction in Semi-Inclusive measurements of Deep-Inelastic Scattering (SIDIS) on unpolarised nucleons allows one to get information on the intrinsic transverse momentum of quarks in a nucleon and on the Boer-Mulders function through the measurement of azimuthal modulations in the cross section. These modulations were recently measured by the HERMES experiment at DESY on proton and deuteron targets, and by the COMPASS experiment using the CERN SPS muon beam and a $^6$LiD target. In both cases, the amplitudes of the $\cos\phi_h$ and $\cos 2\phi_h$ modulations show strong kinematic dependences for both positive and negative hadrons. It has been known since some time that the measu…
Recent Advances in Derivation of Functional Hepatocytes from Placental Stem Cells
2013
Abstract: End-stage liver diseases are one of the leading causes of death in the world. Often orthotopic liver transplantation represents the final therapeutic choice. The limits of this approach are the scarcity of donor livers available, and the many side effects related to the administration of immune suppressants to the patients. Cellular therapy for liver diseases is increasingly being viewed as a promising strategy to provide hepatocytes to replenish the parenchymal cells of the organ. This technique suffers of some important limitations, such as the difficulty in isolating sufficient cell numbers (e.g. when adult or foetal hepatocytes are used for transplantation), the limited viabil…
Homodyne Solid-State Biased Coherent Detection of Ultra-Broadband Terahertz Pulses with Static Electric Fields.
2021
We present an innovative implementation of the solid-state-biased coherent detection (SSBCD) technique, which we have recently introduced for the reconstruction of both amplitude and phase of ultra-broadband terahertz pulses. In our previous works, the SSBCD method has been operated via a heterodyne scheme, which involves demanding square-wave voltage amplifiers, phase-locked to the THz pulse train, as well as an electronic circuit for the demodulation of the readout signal. Here, we demonstrate that the SSBCD technique can be operated via a very simple homodyne scheme, exploiting plain static bias voltages. We show that the homodyne SSBCD signal turns into a bipolar transient when the stat…