Search results for "Modula"
showing 10 items of 1481 documents
Preclinical immunomodulation by the probiotic Bifidobacterium breve M-16V in early life
2016
This study aimed to investigate the effect of supplementation with the probiotic Bifidobacterium breve M-16V on the maturation of the intestinal and circulating immune system during suckling. In order to achieve this purpose, neonatal Lewis rats were supplemented with the probiotic strain from the 6th to the 18th day of life. The animals were weighed during the study, and faecal samples were obtained and evaluated daily. On day 19, rats were euthanized and intestinal wash samples, mesenteric lymph node (MLN) cells, splenocytes and intraepithelial lymphocytes (IEL) were obtained. The probiotic supplementation in early life did not modify the growth curve and did not enhance the systemic immu…
Current modulation induced stability in laser diode under high optical feedback strength
2021
The back-reflection of emitted laser beam (optical feedback, also know as selfmixing) from various external interfaces are sufficient to cause instability, and prohibiting its use in various fields such as communication, spectroscopy, imaging to name a few. So it is desirable to study the laser dynamics and the conditions causing it to be stable in spite of strong optical feedback. With the aid of mathematical formulation, simulation and backed by experimental evidences, it is demonstrated that the frequency deviation of the laser emission due to current (intensity) modulation alters the dynamic state and boundary conditions of the system such that even under large optical feedback strength…
Differential expression patterns of cytokines in complex regional pain syndrome.
2007
Complex regional pain syndromes (CRPS) are characterized by persistent and severe pain after trauma or surgery. Neuro-immune alterations are assumed to play a pathophysiological role. Here we set out to investigate whether patients with CRPS have altered systemic pro- and anti-inflammatory cytokine profiles compared to controls on mRNA and protein level. We studied blood cytokine mRNA and protein levels of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF), interleukin-2 (IL-2) and IL-8 and the anti-inflammatory cytokines IL-4, IL-10, and transforming growth factor-beta1 (TGF beta 1) in 40 prospectively recruited patients with CRPS I, two patients with CRPS II, and 34 controls…
Development of a modular room-temperature hydride storage system for vehicular applications
2016
The subject of this paper concerns the development of a vehicular hydrogen tank system, using a commercial interstitial metal hydride as storage material. The design of the tank was intended to feed a fuel cell in a light prototype vehicle, and the chosen hydride material, Hydralloy C5 by GfE, was expected to be able to absorb and desorb hydrogen in a range of pressure suitable for this purpose. A systematic analysis of the material in laboratory scale allows an extrapolation of the thermodynamic and reaction kinetics data. The following development of the modular tank was done according to the requirements of the prototype vehicle propulsion system and led to promising intermediate results…
European expert opinion on the management of invasive candidiasis in adults
2011
Item does not contain fulltext This report discusses the present status of antifungal therapy and treatment options for candidaemia, considered by experts in the field in Europe. A conference of 26 experts from 13 European countries was held to discuss strategies for the treatment and prevention of invasive candidiasis, with the aim of providing a review on optimal management strategies. Published and unpublished comparative trials on antifungal therapy were analysed and discussed. Commonly asked questions about the management of candidaemia were selected, and possible responses to these questions were discussed. Panellists were then asked to respond to each question by using a touchpad ans…
Gaze cueing in naturalistic scenes under top-down modulation – Effects on gaze behaviour and memory performance
2022
Humans as social beings rely on information provided by conspecifics. One important signal in social communication is eye gaze. The current study (n = 93) sought to replicate and extend previous findings of attentional guidance by eye gaze in complex everyday scenes. In line with previous studies, longer, more and earlier fixations for objects cued by gaze compared to objects that were not cued were observed in free viewing conditions. To investigate how robust this prioritization is against top-down modulation, half of the participants received a memory task that required scanning the whole scene instead of exclusively focusing on cued objects. Interestingly, similar gaze cueing effects oc…
Three-dimensional atomic force microscopy mapping at the solid-liquid interface with fast and flexible data acquisition
2016
We present the implementation of a three-dimensional mapping routine for probing solid-liquid interfaces using frequency modulation atomic force microscopy. Our implementation enables fast and flexible data acquisition of up to 20 channels simultaneously. The acquired data can be directly synchronized with commercial atomic force microscope controllers, making our routine easily extendable for related techniques that require additional data channels, e.g., Kelvin probe force microscopy. Moreover, the closest approach of the tip to the sample is limited by a user-defined threshold, providing the possibility to prevent potential damage to the tip. The performance of our setup is demonstrated …
Insights into Kelvin probe force microscopy data of insulator-supported molecules
2015
We present a detailed analysis and understanding of Kelvin probe force microscopy (KPFM) data for a system of point charges in a vacuum-dielectric tip-sample system. Explicit formulae describing the KPFM signal $\ensuremath{\Delta}V$ are derived for the two KPFM operation modes, namely amplitude modulation and frequency modulation (FM). The formulae allow for a physical interpretation of the resulting KPFM signal, reveal contributing parameters, and especially disclose an additive behavior. We numerically evaluate these equations and show exemplary KPFM slice data for a single point charge. The theoretical analysis is complemented by two-dimensional FM-KPFM maps obtained experimentally on 2…
Uwagi o mowie cynicznej : Kallikles i Trazymach jako mówcy cyniczni
2019
Cynical speech is a proper form of manifestation of what we call cynicism. It takes the form of a persuasive strategy which assumes the achievement of the rhetorical consubstantiation of a cynical speaker and her/his auditorium. Cynical speech is a game that takes place between three sides: a cynical speaker posing as an immoralist, a moralist and an auditorium, the acquisition of which is the aim of both interlocutors. At the outset, the cynical speaker gives the identity of naive dilettantes’ to both the members of the auditorium and the moralist and then tries to persuade the audience to side with him and take on the role of the students of a cynical expert. This is what can be described…
Identification of avarol derivatives as potential antipsoriatic drugs using an in vitro model for keratinocyte growth and differentiation.
2006
Contains fulltext : 49512schalkwijk.pdf (Publisher’s version ) (Closed access) Avarol, a marine sesquiterpenoid hydroquinone, and 14 avarol derivatives have shown interesting anti-inflammatory properties in previous studies. In this study, avarol and derivatives were evaluated in high-throughput keratinocyte culture models using cytokeratin 10 and SKALP/Elafin expression as markers for respectively normal and psoriatic differentiation. Avarol and five of its derivatives (5, 10, 13, 14 and 15) were selected for further study. Only 10, 13, 14 and 15 were able to inhibit keratinocyte cell growth. Changes in expression levels of 22 genes were assessed by quantitative real time PCR (qPCR). From …