Search results for "Modula"
showing 10 items of 1481 documents
The role of hyaluronic acid and amino acid against the aging of the human skin: A clinical and histological study.
2020
Background In esthetic medicine, different techniques have been used against the aging of the human skin especially in the facial area. Hyaluronic acid is used for improving the quantity of water and extracellular matrix molecule. The aim of this study is a clinical and histological evaluation of the effect of low-molecular-weight hyaluronic acid fragments mixed with amino acid (HAAM) on the rejuvenation the face skin treated with intradermal microinjections. Methods Twenty women with mean age 45 range from 35 to 64 were studied, thereof 8 in menopause and 12 of childbearing age. The patients were treated with the HAAM products by mesotherapy technique; before and after 3 months of the ther…
Isolation and Characterization of CD276+/HLA-E+ Human Subendocardial Mesenchymal Stem Cells from Chronic Heart Failure Patients: Analysis of Differen…
2012
Mesenchymal stem cells (MSCs) are virtually present in all postnatal organs as well as in perinatal tissues. MSCs can be differentiated toward several mature cytotypes and interestingly hold potentially relevant immunomodulatory features. Myocardial infarction results in severe tissue damage, cardiomyocyte loss, and eventually heart failure. Cellular cardiomyoplasty represents a promising approach for myocardial repair. Clinical trials using MSCs are underway for a number of heart diseases, even if their outcomes are hampered by low long-term improvements and the possible presence of complications related to cellular therapy administration. Therefore, elucidating the presence and role of MS…
Anatomical Network Comparison of Human Upper and Lower, Newborn and Adult, and Normal and Abnormal Limbs, with Notes on Development, Pathology and Li…
2015
How do the various anatomical parts (modules) of the animal body evolve into very different integrated forms (integration) yet still function properly without decreasing the individual’s survival? This long-standing question remains unanswered for multiple reasons, including lack of consensus about conceptual definitions and approaches, as well as a reasonable bias toward the study of hard tissues over soft tissues. A major difficulty concerns the non-trivial technical hurdles of addressing this problem, specifically the lack of quantitative tools to quantify and compare variation across multiple disparate anatomical parts and tissue types. In this paper we apply for the first time a powerf…
An Experimental Characterization of Time of Arrival Accuracy for Time Synchronization of Medium Voltage Smart Grid Solutions
2019
The time synchronization of smart grid devices is a critical feature for the successful application of advanced grid monitoring and control techniques. Synchronization mechanisms based on the accurate estimation of the Time of Arrival (ToA) of network messages - sent over power line cables - are a promising solution to achieve synchronization tasks over distribution lines. In this paper, a chirp-based synchronization technique over the Medium Voltage (MV) grid has been proposed and characterized. Such approach has the benefit of not requiring the installation of a dedicated infrastructure, thanks to the exploitation of power distribution lines for the transmission of time synchronization da…
Setup for Characterization of the Non-Linear Electric Susceptibility in the Microwave Range Applied to a Glass Ceramic
2019
A resonator method exciting eigenresonances of three coupled cylindrical dielectric resonators allows characterizing the non-linear response of low loss and high permittivity materials at frequencies of about 1 GHz. To reach the necessary sensitivity for dielectric non-linearities, the setup ensures that the measured intermodulation can be ascribed to the material under test while all other intermodulation sources are excluded. Electric field amplitudes of several V/mm are obtained at an input power of 100 W. The setup was used to characterize the third order non-linear susceptibility of a glass ceramic.
Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lym…
2022
Lymphomas are among the ten most common cancers, and, although progress has been achieved in increasing survival, there is still an unmet need for more effective therapeutic approaches, including better options for patients with refractory tumors that initially respond but then relapse. The lack of effective alternative treatment options highlights the need to develop new therapeutic strategies capable of improving survival prospects for lymphoma patients. Herein, we describe the identification and exploration of the SAR of a series of [1,2]oxazolo[5,4-e]isoindoles as potent small molecules that bind to the colchicine site of tubulin and that have promise for the treatment of refractory lym…
Endocannabinoid signals in the control of emotion.
2008
The appropriate control of emotional responses evoked by environmental stimuli is an important innate mechanism for ensuring quality of life and even for survival. Inappropriate responses and decreased abilities to adjust to changed environmental situations can lead to psychiatric disorders, such as posttraumatic stress disorders, phobia and depression. Endocannabinoid signalling has emerged as one of the regulatory systems of the brain supporting appropriate emotional responses. As various components of the endocannabinoid system have become therapeutic targets, understanding the endocannabinoids’ mechanism of action is an important research topic for a rationalized drug design and optimal…
High-repetition-rate source delivering optical pulse trains with a controllable level of amplitude and temporal jitters
2020
International audience; We theoretically propose and numerically validate an all-optical scheme to generate optical pulse trains with varying peak-powers and durations. A shaping of the spectral phase thanks to discrete /2 phase shifts enables an efficient phase-to-intensity conversion of a temporal phase modulation based on a two-tone sinusoidal beating. Experiments carried out at telecommunication wavelengths and at a repetition rate of 10 GHz confirm the ability of our approach to efficiently generate a train made of pulses with properties that vary from pulse-to-pulse. The levels of jitters can be accurately controlled.
Quantum Critical Scaling under Periodic Driving
2016
Universality is key to the theory of phase transition stating that the equilibrium properties of observables near a phase transition can be classified according to few critical exponents. These exponents rule an universal scaling behaviour that witnesses the irrelevance of the model's microscopic details at criticality. Here we discuss the persistence of such a scaling in a one-dimensional quantum Ising model under sinusoidal modulation in time of its transverse magnetic field. We show that scaling of various quantities (concurrence, entanglement entropy, magnetic and fidelity susceptibility) endures up to a stroboscopic time $\tau_{bd}$, proportional to the size of the system. This behavio…
Clathration of Five-Membered Aromatic Rings in the Bimetallic Spin Crossover Metal–Organic Framework [Fe(TPT)2/3{MI(CN)2}2]·G (MI = Ag, Au)
2014
Six clathrate compounds of the three-dimensional spin crossover metal−organic framework formulated [Fe(TPT)2/3{MI (CN)2}2]· nG, where TPT is 2,4,6-tris(4-pyridyl)-1,3,5-triazine, MI = Ag or Au and G represent the guest molecules furan, pyrrole and thiophene, were synthesized using slow diffusion techniques. The clathrate compounds were characterized by single-crystal X-ray diffraction at 120 and 300 K, thermogravimetric analysis and thermal dependence of the magnetic susceptibility. All compounds crystallize in the R3̅ m trigonal space group. The FeII defines a unique [FeN6] crystallographic site with the equatorial positions occupied by four dicyanometallate ligands while the axial positio…