Search results for "Modulator"
showing 10 items of 210 documents
Wharton's jelly mesencymal stem cells differentiated into hepatocyte-like cells show expression of immunomodulatory molecules
2014
A New Model for Sigma-Delta Modulator Oriented to Digitally Controlled DC/DC Converter
2007
Recent research activities have shown the feasibility and advantages of using digital controller ICs specifically developed for high-frequency switching converters, highlighting a challenging future trend in Switched-mode power supplies (SMPS) applications. Up to a few years ago, the application of digital control for SMPS was impractical due to the high cost and low performance of DSP and microcontroller systems, even if the advantages that digital controllers offer were well known, such as immunity to analog component variations and ability to implement sophisticated control schemes and system diagnostics. Digital controller ICs potentially offer other advantages from the integrated desig…
Periodic time-domain modulation for the electrically tunable control of optical pulse train envelope and repetition rate multiplication
2012
An electrically tunable system for the control of optical pulse sequences is proposed and demonstrated. It is based on the use of an electrooptic modulator for periodic phase modulation followed by a dispersive device to obtain the temporal Talbot effect. The proposed configuration allows for repetition rate multiplication with different multiplication factors and with the simultaneous control of the pulse train envelope by simply changing the electrical signal driving the modulator. Simulated and experimental results for an input optical pulse train of 10 GHz are shown for different multiplication factors and envelope shapes. © 2006 IEEE.
Optical retarder system with programmable spectral retardance.
2014
An optical system that works as a retarder waveplate with programmable spectral retardance is proposed. The system is based on a pixelated liquid crystal on silicon (LCoS) spatial light modulator (SLM). The input light beam is spectrally dispersed and different spectral components are projected onto different pixels of the LCoS-SLM. A different retardance is then addressed for each pixel, adapted to the incoming wavelength. Light reflected from the SLM is then recombined by the same setup. In this way a programmable polarization spectrum can be encoded. We illustrate the broadband characterization that is required for proper use of the system. Then several examples are shown, including spec…
Single-channel polychromatic pattern recognition by the use of a joint-transform correlator.
2010
We present a single-channel system for color image recognition that is based on a joint-transform correlator setup. The color images are encoded as phase and amplitude functions, inspired from the Munsell color representation. A real-time implementation of the new codification method can be achieved by the use of a spatial light modulator operating in phase-only modulation mode. We determine the optimal codification for a linear color-phase code. Its performance is compared with a conventional multichannel correlator by means of computer simulations. Experimental results are also presented.
Dispersion management in two-photon microscopy by using diffractive optical elements.
2013
We demonstrate efficient generation of wide-field fluorescence signals in two-photon microscopy exploiting diffractive optical elements and short pulses by using a dispersion-compensated beam delivery optics module. Computer-generated holograms are codified onto a phase-only spatial light modulator, which allows for arbitrary single-shot patterning of the sample. Spatiotemporal shaping of the pulse is mandatory to overcome spatial chirp and pulse-front tilt effects that spread both in space and time the irradiance patterns, thus limiting not only the spatial resolution but also the signal-to-noise ratio in two-photon microscopy. By using a multipass amplifier delivering 30 fs, 0.8 mJ pulses…
Dynamical binary modulation of ultrabroadband light beams by using principal states of polarization of liquid crystal devices
2009
Dynamical modulation of ultrabroadband beams, such as those produced by femtosecond laser or incoherent sources, is not an easy task due to the dispersive nature of the devices commonly employed. Phase modulation has been performed by means of deformable micromirror arrays. These devices are expensive and do not permit amplitude modulation. For micro- and nano-structuring of materials with femtosecond lasers is common to pattern the surface with the light irradiance produced by a computer generated hologram implemented onto a liquid crystal (LC) type spatial light modulator. This enables dynamical patterning [1,2]. Reduced spectral bandwidths, of the order of tens of nanometers, have been u…
Super Resolution Methods Implementing Diffractive Masks Having a Certain Degree of Periodicity
2011
This section presents an approach that provides super resolved imaging at the center of the field of view and yet allows to see the remaining of the original field of view with original resolution. This operation resembles optical zooming while the zoomed and the nonzoomed images are obtained simultaneously. This is obtained by taking a single snap-shot and using a single imaging lens. The technique utilizes a special static/still coding element and a postprocessing algorithmic, without any mechanical movements.
Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers.
2021
The SF3B1 protein, part of the SF3b complex, recognizes the intron branch point sequence of precursor messenger RNA (pre-mRNA), thus contributing to splicing fidelity. SF3B1 is frequently mutated in cancer and is the target of distinct families of splicing modulators (SMs). Among these, H3B-8800 is of particular interest, as it induces preferential lethality in cancer cells bearing the frequent and highly pathogenic K700E SF3B1 mutation. Despite the potential of H3B-8800 to treat myeloid leukemia and other cancer types hallmarked by SF3B1 mutations, the molecular mechanism underlying its preferential lethality towards spliceosome-mutant cancer cells remains elusive. Here, microsecond-long a…
Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.
2007
Two new series of inhibitors of tubulin polymerization based on the 2-amino-3-(3,4,5-trimethoxybenzoyl)benzo[b]thiophene molecular skeleton and its 3-amino positional isomer were synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell cycle effects. Although many more 3-amino derivatives have been synthesized so far, the most promising compound in this series was 2-amino-6-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]thiophene, which inhibits cancer cell growth at subnanomolar concentrations and interacts strongly with tubulin by binding to the colchicine site.