Search results for "Moduli"
showing 10 items of 206 documents
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis
2021
Development of primary liver cancer is a multistage process. Detailed understanding of sequential epigenetic alterations is largely missing. Here, we performed Infinium Human Methylation 450k BeadChips and RNA-Seq analyses for genome-wide methylome and transcriptome profiling of cirrhotic liver (n = 7), low- (n = 4) and high-grade (n = 9) dysplastic lesions, and early (n = 5) and progressed (n = 3) hepatocellular carcinomas (HCC) synchronously detected in 8 patients with HCC with chronic hepatitis B infection. Integrative analyses of epigenetically driven molecular changes were identified and validated in 2 independent cohorts comprising 887 HCCs. Mitochondrial DNA sequencing was further em…
Serum thrombomodulin—a reliable marker of disease activity in systemic lupus erythematosus (SLE): advantage over established serological parameters t…
1999
SUMMARYTo date no specific serological parameter is available to assess disease activity in SLE. Soluble serum thrombomodulin is a new marker of endothelial cell injury and vasculitis. The objective of this study was to compare in vivo soluble thrombomodulin as marker of disease activity in SLE with established and recent serological parameters. One hundred and twenty-four sera of 30 patients with proven SLE with different disease activities were tested for serum levels of thrombomodulin, intercellular adhesion molecule-1 (ICAM-1), E-selectin, vascular cell adhesion molecule-1 (VCAM-1), IL-2R, IL-6, IL-10, dsDNA by ELISA and dsDNA additionally by radioimmunoassay (RIA). C-reactive protein (…
Expression of PSA-NCAM and synaptic proteins in the amygdala of psychiatric disorder patients.
2011
Neuroimaging has revealed structural abnormalities in the amygdala of different psychiatric disorders. The polysialylated neural cell adhesion molecule (PSA-NCAM), a molecule related to neuronal structural plasticity, which expression is altered in schizophrenia, major depression and in animal models of these disorders, may participate in these changes. However, PSA-NCAM has not been studied in the human amygdala. To know whether its expression and that of presynaptic markers, was affected in psychiatric disorders, we have analyzed post-mortem sections from the Stanley Neuropathology Consortium, which includes controls, schizophrenia, bipolar and major depression patients. PSA-NCAM was expr…
OASIS-HT: design of a pharmacogenomic dose-finding study.
2005
Experimental evidence and observations in humans strongly support an interactive role of mutated α-adducin, sodium (Na+)/potassium (K+)-adenosine triphosphatase (ATPase) activity and endogenous ouabain in Na+homeostasis and the pathogenesis of hypertension. The Ouabain and Adducin for Specific Intervention on Sodium in HyperTension (OASIS-HT) trial is an early Phase II dose-finding study, which will be conducted across 39 European centers. Following a run-in period of 4 weeks without treatment, eligible patients will be randomized to one of five oral doses of rostafuroxin consisting of 0.05, 0.15, 0.5, 1.5, or 5.0 mg/day. Each dose will be compared to a placebo in a double-blind crossover e…
Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine.
2008
The persistent nature of addiction has been associated with activity-induced plasticity of neurons within the striatum and nucleus accumbens (NAc). To identify the molecular processes leading to these adaptations, we performed Cre/loxP-mediated genetic ablations of two key regulators of gene expression in response to activity, the Ca 2+ /calmodulin-dependent protein kinase IV (CaMKIV) and its postulated main target, the cAMP-responsive element binding protein (CREB). We found that acute cocaine-induced gene expression in the striatum was largely unaffected by the loss of CaMKIV. On the behavioral level, mice lacking CaMKIV in dopaminoceptive neurons displayed increased sensitivity to cocai…
SugarCRM - Pasūtījumu modulis
2015
Pasūtījumu modulis ir jauna SugarCRM komponente, kura ir realizēta SugarCRM sistēmā. Tās galvenais uzdevums ir nodrošināt iespēju lietotājam izveidot pasūtījumus SugarCRM sistēmā. Lietotājam ir ļauts izveidot jaunus pasūtījumus no sistēmā jau esošā Piedāvājumu moduļa vai izveidot tos kā nesaistītus pasūtījumus, izveidojot jaunus produktus vai tos izvēloties no esoša kataloga. Projekts realizēts pēc spējās (Agile) izstrādes metodoloģijas. Programmatūras izstrādes procesā izmantots SugarCRM API, programmēšanas valodas – PHP, Javascript, HTML/CSS un atsevišķas šo valodu bibliotēkas, un MySQL datu bāžu pārvaldības sistēma.
Complex multiplication, Griffiths-Yukawa couplings, and rigidity for families of hypersurfaces
2003
Let M(d,n) be the moduli stack of hypersurfaces of degree d > n in the complex projective n-space, and let M(d,n;1) be the sub-stack, parameterizing hypersurfaces obtained as a d fold cyclic covering of the projective n-1 space, ramified over a hypersurface of degree d. Iterating this construction, one obtains M(d,n;r). We show that M(d,n;1) is rigid in M(d,n), although the Griffiths-Yukawa coupling degenerates for d<2n. On the other hand, for all d>n the sub-stack M(d,n;2) deforms. We calculate the exact length of the Griffiths-Yukawa coupling over M(d,n;r), and we construct a 4-dimensional family of quintic hypersurfaces, and a dense set of points in the base, where the fibres ha…
Special Families of Curves, of Abelian Varieties, and of Certain Minimal Manifolds over Curves
2006
This survey article discusses some results on the structure of families f:V-->U of n-dimensional manifolds over quasi-projective curves U, with semistable reduction over a compactification Y of U. We improve the Arakelov inequality for the direct images of powers of the dualizing sheaf. For families of Abelian varieties we recall the characterization of Shimura curves by Arakelov equalities. For families of curves we recall the characterization of Teichmueller curves in terms of the existence of certain sub variation of Hodge structures. We sketch the proof that the moduli scheme of curves of genus g>1 can not contain compact Shimura curves, and that it only contains a non-compact Shimura c…
Activation of c-Jun N-terminal kinase 1 by UV irradiation is inhibited by wortmannin without affecting c-iun expression.
1999
Activation of c-Jun N-terminal kinases (JNKs)/stress-activated protein kinases is an early response of cells upon exposure to DNA-damaging agents. JNK-mediated phosphorylation of c-Jun is currently understood to stimulate the transactivating potency of AP-1 (e.g., c-Jun/c-Fos; c-Jun/ATF-2), thereby increasing the expression of AP-1 target genes. Here we show that stimulation of JNK1 activity is not a general early response of cells exposed to genotoxic agents. Treatment of NIH 3T3 cells with UV light (UV-C) as well as with methyl methanesulfonate (MMS) caused activation of JNK1 and an increase in c-Jun protein and AP-1 binding activity, whereas antineoplastic drugs such as mafosfamide, mito…
A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicans.
1998
The Candida albicans MKC1 gene encodes a mitogen-activated protein (MAP) kinase, which has been cloned by complementation of the lytic phenotype associated with Saccharomyces cerevisiae slt2 (mpk1) mutants. In this work, the physiological role of this MAP kinase in the pathogenic fungus C. albicans was characterized and a role for MKC1 in the biogenesis of the cell wall suggested based on the following criteria. First, C. albicans mkc1Δ/mkc1Δ strains displayed alterations in their cell surfaces under specific conditions as evidenced by scanning electron microscopy. Second, an increase in specific cell wall epitopes (O-glycosylated mannoprotein) was shown by confocal microscopy in mkc1Δ/mkc1…