Search results for "Moi"

Rituximab in the treatment of non-Hodgkin’s lymphoma

2008

Beate Hauptrock, Georg HessHematology/Oncology, Johannes Gutenberg-University, Mainz, GermanyAbstract: Besides traditional cytostatic drugs the introduction of monoclonal antibodies has substantially influenced current treatment concepts of non-Hodgkin’s lymphoma (NHL).  Rituximab, a monoclonal anti-CD20 chimeric antibody, now has been widely evaluated in the various B-cell lymphatic neoplasms. Large phase III studies helped to prove the value of this drug in follicular lymphoma as part of induction or relapse treatment as well as maintenance treatment. The addition of rituximab to the well established CHOP regimens has increased achievable cure rates in diffuse large cel…

Familial colorectal cancer risk: ESMO Clinical Practice Guidelines.

2010

Mesenteric Lymph Node Involvement in Advanced Ovarian Cancer Patients Undergoing Rectosigmoid Resection: Prognostic Role and Clinical Considerations

2014

Background: The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). Methods: OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progression-free survival (PFS) and overall survival were calculated from the date of diagnosis to the date of relapse/progression, death of disease, or the date of last follow-up. Results: MLNs were detected in 102/148 cases (68.9 %); the rate of MLN involvement was 47.0 %. The percentage of metastatic MLNs was higher in cases with >5 MLNs removed compared with cases with ≤5 MLNs …

Programmed colorectal cancer screening decreases incidence and mortality

2019

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer- related deaths in the world (1). Detecting and removing precancerous lesions or detecting tumors in early stages through endoscopy decreases CRC mortality (2). Randomized controlled trials (RCTs) have shown that CRC screening based on guaiac fecal occult blood testing (gFOBT) and flexible sigmoidoscopy is effective in reducing incidence and mortality rates of CRC (3).

Correlations Between Ofatumumab Exposure and Treatment Outcomes for patients with Chronic Lymphocytic Leukemia (CLL) Treated with Frontline Ofatumuma…

2011

Abstract Abstract 1793 Introduction: Results: Seven pts (4 male) with a medianLittle is known about the pharmacokinetics (PK) and pharmacodynamics of CD20 monoclonal antibody (mAb) with chemotherapy in patients (pts) with CLL. Ofatumumab (O) is a human mAb targeting a membrane-proximal small-loop epitope on CD20 and mediates efficient complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity. Safety and efficacy of O at 2 dose levels in combination with fludarabine and cyclophosphamide (FC) were evaluated in previously untreated pts with CLL. Relationship between O PK, baseline characteristics, and clinical outcomes were studied. Pts and Methods: Pts with active CL…

A Computationally Inexpensive Approach in Multiobjective Heat Exchanger Network Synthesis

2010

We consider a heat exchanger network synthesis problem formulated as a multiobjective optimization problem. The Pareto front of this problem is approximated with a new approximation approach and the preferred point on the approximation is found with the interactive multiobjective optimization method NIMBUS. Using the approximation makes the solution process computationally inexpensive. Finally, the preferred outcome on the Pareto front approximation is projected on the actual Pareto front. peerReviewed

Moiré with zone plates pseudo-randomly encoded

1993

Abstract Moire patterns are a convenient method for optically sensing lateral displacements, or in-plane rotations. Sharp moire fringes are here created by using two zone plates, pseudo-randomly encoded. Our results may be useful in metrology, optical testing, and robotics. Experimental results are reported.

Moir\'e with flat bands is different

2019

Recent experimental discoveries of superconductivity and other exotic electronic states in twisted bilayer graphene (TBG) call for a reconsideration of our traditional theories of these states, usually based on the assumption of the presence of a Fermi surface. Here we show how such developments may even help us finding mechanisms of increasing the critical temperature of superconductivity towards the room temperature.

Existence for shape optimization problems in arbitrary dimension

2002

We discuss some existence results for optimal design problems governed by second order elliptic equations with the homogeneous Neumann boundary conditions or with the interior transmission conditions. We show that our continuity hypotheses for the unknown boundaries yield the compactness of the associated characteristic functions, which, in turn, guarantees convergence of any minimizing sequences for the first problem. In the second case, weaker assumptions of measurability type are shown to be sufficient for the existence of the optimal material distribution. We impose no restriction on the dimension of the underlying Euclidean space.

Fixed domain approaches in shape optimization problems with Dirichlet boundary conditions

2009

Fixed domain methods have well-known advantages in the solution of variable domain problems including inverse interface problems. This paper examines two new control approaches to optimal design problems governed by general elliptic boundary value problems with Dirichlet boundary conditions. Numerical experiments are also included peerReviewed