Search results for "Mono"
showing 10 items of 6843 documents
Antibody-drug conjugates for lymphoma patients: preclinical and clinical evidences
2022
Antibody-drug conjugates (ADCs) are a recent, revolutionary approach for malignancies treatment, designed to provide superior efficacy and specific targeting of tumor cells, compared to systemic cytotoxic chemotherapy. Their structure combines highly potent anti-cancer drugs (payloads or warheads) and monoclonal antibodies (Abs), specific for a tumor-associated antigen, via a chemical linker. Because the sensitive targeting capabilities of monoclonal Abs allow the direct delivery of cytotoxic payloads to tumor cells, these agents leave healthy cells unharmed, reducing toxicity. Different ADCs have been approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (…
Dabīgu imūnmodulatoru kvalitātes kontroles metožu izvērtējums un stimulējošās iedarbības salīdzinājums ar baktēriju endotoksīnu
2016
Darba mērķis bija raksturot dabīga imūnmodulatora AMP dezamināzes aktivitāti saturoša glikoproteīnu kompleksa (AMPD) darbību in vitro un novērtēt, vai šī iedarbība nav saistīta ar iespējamo endotoksīna (LPS) piesārņojumu. Tika izvērtētas AMPD attīrīšanas metodes, salīdzināta AMPD, LPS un lentināna ietekme uz iekaisuma citokīnu sekrēciju mononukleārajās šūnās, kā arī uz dermas fibroblastu proliferāciju. AMPD frakcijas sastāvs un polisaharīda daļas iespējami strukturālā līdzība ar LPS sarežģīja kvalitātes kontroli. Tāpat kā LPS, AMPD stimulēja TNF un IL-6 produkciju un veicināja dermas fibroblastu proliferāciju ar imūnšūnu sekretēto proteīnu starpniecību. LPS neitralizēšanai izmantojamās met…
A discourse on the textual-psychoidal duality in the novel "Thorn and Laurel" ["Cierń i laur"] by Wladyslaw Lech Terlecki
2018
Discourse on textual-psychoidal duality in Władysław Lech Terlecki’s novel Cierń i laur (Thorn and Laurel). The topic of the novel Cierń i Laur (Thorn and Laurel) by Władysław Lech Terlecki (1933-1999) is the fate of Master - a nameless author of historical novels whose real model might be Józef Ignacy Kraszewski (1812-1887) - a nineteenth century author of historical and domestic fiction, well known in Europe of that time. His last romance coincides with his another novel written simultaneously - two fictional perspectives penetrate and illuminate each other. The play of mirror reflections, elements of chest-like composition and duality of inter-textual perspective find explanation in inte…
The occurrence of Echinorhynchus salmonis Müller, 1784 in benthic amphipods in the Baltic Sea
2015
The acanthocephalan Echinorhynchus salmonis Muller, 1784 is a common parasite of salmonid fish, but it has rarely been reported from an intermediate host. Samples of benthic amphipods, Monoporeia affinis (Lindstrom), were taken from multiple, deep sites (usually below 70 m) in the Gulf of Bothnia over the course of more than a decade and examined for acanthocephalans. Overall, only 0.44% of 23 296 amphipods were infected, all with just a single worm. This prevalence is consistent with several previous reports of acanthocephalans in deep-water, benthic amphipods, but it appears low compared to that often reported for acanthocephalan species infecting littoral amphipods. Parasite occurrence d…
Efecto de la Sobrecarga oral con grasa insaturada en los marcadores de estrés oxidativo y expresión de ARN lifomonocitos en sujeto con Diabetes Melli…
2016
La enfermedad cardiovascular (ECV) es la principal causa de mortalidad en nuestro medio. Está causada por diferentes factores de riesgo entre los que se encuentran la diabetes mellitus (DM), el tabaquismo, la hipertensión arterial (HTA) y la dislipemia (DL). El termino DM describe diferentes enfermedades del metabolismo de los carbohidratos, que se caracterizan por la hiperglucemia crónica y son causadas por el déficit de secreción de insulina o por la resistencia a la acción de la misma. La causa mas frecuente de mortalidad en los pacientes con DM2 es la ECV. El riesgo cardiovascular en la DM2 viene mediado no solo por la hiperglucemia, sino también por el resto de factores de riesgo clási…
CCDC 1880078: Experimental Crystal Structure Determination
2019
Related Article: Wenqian Shan, Nicolas Desbois, Sandrine Pacquelet, Stéphane Brandès, Yoann Rousselin, Jeanet Conradie, Abhik Ghosh, Claude P. Gros, Karl M. Kadish|2019|Inorg.Chem.|58|7677|doi:10.1021/acs.inorgchem.8b03006
The image of the monolingual dictionary across Europe. Results of the European Survey of Dictionary use and Culture
2019
The article presents the results of a survey on dictionary use in Europe, focusing on general monolingual dictionaries. The survey is the broadest survey of dictionary use to date, covering close to 10,000 dictionary users (and non-users) in nearly thirty countries. Our survey covers varied user groups, going beyond the students and translators who have tended to dominate such studies thus far. The survey was delivered via an online survey platform, in language versions specific to each target country. It was completed by 9,562 respondents, over 300 respondents per country on average. The survey consisted of the general section, which was translated and presented to all participants, as wel…
Monotonicity Formulas for Harmonic Functions in RCD(0,N) Spaces
2023
We generalize to the RCD(0,N) setting a family of monotonicity formulas by Colding and Minicozzi for positive harmonic functions in Riemannian manifolds with nonnegative Ricci curvature. Rigidity and almost rigidity statements are also proven, the second appearing to be new even in the smooth setting. Motivated by the recent work in Agostiniani et al. (Invent. Math. 222(3):1033–1101, 2020), we also introduce the notion of electrostatic potential in RCD spaces, which also satisfies our monotonicity formulas. Our arguments are mainly based on new estimates for harmonic functions in RCD(K,N) spaces and on a new functional version of the ‘(almost) outer volume cone implies (almost) outer metric…
A study of the atmospherically important reactions of dimethylsulfide (DMS) with I2 and ICl using infrared matrix isolation spectroscopy and electron…
2012
The reactions of dimethylsulfide (DMS) with molecular iodine (I(2)) and iodine monochloride (ICl) have been studied by infrared matrix isolation spectroscopy by co-condensation of the reagents in an inert gas matrix. Molecular adducts of DMS + I(2) and DMS + ICl have also been prepared using standard synthetic methods. The vapour above each of these adducts trapped in an inert gas matrix gave the same infrared spectrum as that recorded for the corresponding co-condensation reaction. In each case, the infrared spectrum has been interpreted in terms of a van der Waals adduct, DMS : I(2) and DMS : ICl, with the aid of infrared spectra computed for their minimum energy structures at the MP2 lev…
CCDC 782553: Experimental Crystal Structure Determination
2016
Related Article: Hélène Bertrand, Anton Granzhan, David Monchaud, Nicolas Saettel, Régis Guillot, Sarah Clifford, Aurore Guédin, Jean-Louis Mergny, Marie-Paule Teulade-Fichou|2011|Chem.-Eur.J.|17|4529|doi:10.1002/chem.201002810