Search results for "Mores"

Cáncer en los primeros 18 meses de vida

2020

Resumen: Introducción: La enfermedad oncohematológica continúa siendo la primera causa de mortalidad no traumática en la infancia y una importante causa de morbilidad. El paciente menor de 18 meses presenta particularidades clínicas, diagnósticas y terapéuticas que es interesante conocer por todo pediatra, con el fin de lograr una mayor supervivencia y una menor comorbilidad a lo largo de su vida. Material y métodos: Estudio descriptivo retrospectivo de variables clínicas, diagnósticas y terapéuticas en pacientes menores de 18 meses diagnosticados de enfermedad oncohematológica que reciben quimioterapia en una unidad de oncología pediátrica entre enero 2007 y agosto 2019. Resultados: Setent…

A quest for initiating cells of head and neck cancer and their treatment.

2010

The biology of head and neck squamous cell carcinomas (HNSCC) and other cancers have been related to cancer stem-like cells (CSC). Specific markers, which vary considerably depending on tumor type or tissue of origin, characterize CSC. CSC are cancer initiating, sustaining and mostly quiescent. Compared to bulk tumors, CSC are less sensitive to chemo- and radiotherapy and may have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome. HNSCC has two main etiologies: human papillomavirus, a virus infecting epithelial stem cells, and tobacco and alcohol abuse. Here, current knowledge of HNSCC-CSC biology is reviewed and parallels to CSC of other origin are drawn where n…

Μετάβασις εἰς ἄλλο γένος: scelte biotiche e interdetti negli Amores

2018

The Amores’ collection is rich in declarations of literary intents, among which the introductory poem stands out: in this elegy the poet announces a metabasis eis allo genos, by blending echos from Bio frr. 3 e 10 G. with echoes from Prop. 2.13a.1-4, in order to legitimise the transition from the original epic inspiration to the elegiac one. The motif occurs again in 2.1 and 18: in the first case Ovid justifies, for the second time, this evolution, in the latter he informs the reader of his comeback to the erotic elegy, after a break in the space of the tragedy and of the didascalic and/or epistolary poetry with erotic content (Ars, Heroides). Later, in Am. 3.1 the famous dispute between El…

Odontogenic tumors in children and adolescents: A 15-year retrospective study in Argentina

2007

There are few studies on bucco-maxillary lesions in children and adolescents, and reports on odontogenic tumors (OT) are scanty. Comparison among the available data is difficult due to differences in the criteria used in each study. The aim of the present work was to perform a retrospective study of OT in patients aged up to 20 years diagnosed at a center specialized in histopathologic diagnosis of oral diseases. All cases diagnosed with OT between 1990 and 2004 were retrieved from the Service archives. The 153 retrieved cases accounted for 7% of total biopsies performed during that period, and to 78.4% of tumors of the jaws. Mean age of the whole population was 12.7 years and the male to f…

Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides.

2021

The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins. On the basis of genetic evidence, it has been postulated that the FHIT protein may function as tumor suppressor, implying a role for the FHIT protein in carcinogenesis. Recently, Gaudio et al. reported that FHIT binds and delocalizes annexin A4 (ANXA4) from plasma membrane to cytosol in paclitaxel-resistant lung cancer cells, thus restoring their chemosensitivity to the drug. They also identified the smallest protein sequence of the FHIT still interacting with ANXA4, ranging from position 7 to 13: QHLIKPS. This short sequence of FHIT protein was not only able to bind …

Rapid detergent exchange in solutions of the membrane protein bacteriorhodopsin by preparative high-performance liquid chromatography (HPLC)

1984

Prognostic Impact of let-7e MicroRNA and Its Target Genes in Localized High-Risk Intestinal GIST: A Spanish Group for Research on Sarcoma (GEIS) Study

2020

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level, and they have been described as being associated with tumor prognosis. Here, miRNA profiling was planned to explore new molecular prognostic biomarkers in localized intestinal high-risk GIST. Paraffin tumor blocks of 14 and 86 patients were used in the discovery and expansion sets, respectively. GeneChip miRNA v3.0 was employed to identify the miRNAs differentially expressed between relapsed and non-relapsed patient samples, which were validated in the expansion set, by qRT-PCR. RT2 Profiler PCR Array was used for the screening of let-7e targets. Expression levels were co…

Uloga glazbe u dubrovackom pastoralnom teatru u 16. stoljecu. (The Role of the Music in the Pastoral Theatre in Dubrovnik during the Sixteenth Centur…

2004

The 16th-century pastoral plays in Dubrovnik (Ragusa), like the Italian ones which inspired them, are marked by the strong presence of sounds, songs and choruses to increase the fantastical and sentimental emphasis of the performances. Their evolution, from Dzore Drzic eclogues to the pastorals of Antun Sasin, and through Mauro Vetranovic's "Orfeo", is characterized by the acquisition of a Petrarchian language in the Croatian pieces of Nikola Naljeskovic. In the Dubrovnik pastoral plays, unlike the Italian ones, the presence of shepherds, nymphs, and rustic men (the "vlasi", Engl. Walachians or Morlacks) as well as the fantastic and comic elements, is constant. Music supports a narrative fu…

Novel Lymphocyte-Independent Antitumor Activity by PD-1 Blocking Antibody against PD-1+ Chemoresistant Lung Cancer Cells

2022

Abstract Purpose: Antibodies against the lymphocyte PD-1 (aPD-1) receptor are cornerstone agents for advanced non–small cell lung cancer (NSCLC), based on their ability to restore the exhausted antitumor immune response. Our study reports a novel, lymphocyte-independent, therapeutic activity of aPD-1 against NSCLC, blocking the tumor-intrinsic PD-1 receptors on chemoresistant cells. Experimental Design: PD-1 in NSCLC cells was explored in vitro at baseline, including stem-like pneumospheres, and following treatment with cisplatin both at transcriptional and protein levels. PD-1 signaling and RNA sequencing were assessed. The lymphocyte-independent antitumor activity of aPD-1 was explored in…

Immunotherapy targeting colon cancer stem cells

2010

In the last 10 years, cancer stem cells have interested the scientific community because this small tumorigenic population is also associated with tumor progression in human patients and specific targeting of cancer stem cells could be a strategy to eradicate cancers currently resistant to conventional therapy. Clinical studies have recently demonstrated that adding immune therapy to chemotherapy has survival benefits in comparison with chemotherapy alone that can sensitize tumors to immune cell-mediated killing (e.g., increasing sensitivity of tumor cells to subsequent cytotoxicity by T cells via upregulation of death receptors DR5 and Fas). However, loss of MHC molecules is often observe…