Search results for "Morphisms"
showing 10 items of 190 documents
Foxp3 and gata3 polymorphisms, vitamin d3 and multiple sclerosis
2021
Background: Regulatory T cells (Tregs) alterations have been implicated in the pathogenesis of Multiple Sclerosis (MS). Recently, a crucial role of the X-Linked Forkhead Box P3 (FoxP3) for the development and the stability of Tregs has emerged, and FOXP3 gene polymorphisms have been associated with the susceptibility to autoimmune diseases. The expression of Foxp3 in Tregs is regulated by the transcription factor GATA binding-protein 3 (GATA3) and vitamin D3. The aim of this retrospective case-control study was to investigate the potential association between FOXP3 and GATA3 genetic variants, Vitamin D3, and MS risk. Methods: We analyzed two polymorphisms in the FOXP3 gene (rs3761547 and rs…
Irreducible components of Hurwitz spaces of coverings with two special fibers
2013
In this paper we prove new results of irreducibility for Hurwitz spaces of coverings whose monodromy group is a Weyl group of type B_d and whose local monodromies are all reflections except two.
Importance of dispersal and thermal environment for mycorrhizal communities: lessons from Yellowstone National Park
2011
International audience; The relative importance of dispersal and niche restrictions remains a controversial topic in community ecology, especially for microorganisms that are often assumed to be ubiquitous. We investigated the impact of these factors for the community assembly of the root-symbiont arbuscular mycorrhizal fungi (AMF) by sampling roots from geothermal and nonthermal grasslands in Yellowstone National Park (YNP), followed by sequencing and RFLP of AMF ribosomal DNA. With the exception of an apparent generalist RFLP type closely related to Glomus intraradices, a distance-based redundancy analysis indicated that the AMF community composition correlated with soil pH or pH-driven c…
Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients.
2006
Abstract Background: Impaired DNA repair capacity may favorably affect survival in cisplatin/gemcitabine-treated non-small-cell lung cancer (NSCLC) patients. We investigated the association of survival with genetic polymorphisms in X-ray repair cross-complementing group 1 and group 3 (XRCC3), xeroderma pigmentosum group D (XPD), excision repair cross-complementing group 1, ligase IV, ribonucleotide reductase, TP53, cyclooxygenase-2, interleukin-6, peroxisome proliferator-activated receptor γ, epidermal growth factor, methylene-tetra-hydrofolate reductase and methionine synthase. Patients and methods: One hundred and thirty-five stage IV or IIIB (with malignant pleural effusion) NSCLC patien…
Building Anosov flows on $3$–manifolds
2014
We prove a result allowing to build (transitive or non-transitive) Anosov flows on 3-manifolds by gluing together filtrating neighborhoods of hyperbolic sets. We give several applications; for example: 1. we build a 3-manifold supporting both of a transitive Anosov vector field and a non-transitive Anosov vector field; 2. for any n, we build a 3-manifold M supporting at least n pairwise different Anosov vector fields; 3. we build transitive attractors with prescribed entrance foliation; in particular, we construct some incoherent transitive attractors; 4. we build a transitive Anosov vector field admitting infinitely many pairwise non-isotopic trans- verse tori.
Embedding mapping class groups of orientable surfaces with one boundary component
2012
We denote by $S_{g,b,p}$ an orientable surface of genus $g$ with $b$ boundary components and $p$ punctures. We construct homomorphisms from the mapping class groups of $S_{g,1,p}$ to the mapping class groups of $S_{g',1,(b-1)}$, where $b\geq 1$. These homomorphisms are constructed from branched or unbranched covers of $S_{g,1,0}$ with some properties. Our main result is that these homomorphisms are injective. For unbranched covers, this construction was introduced by McCarthy and Ivanov~\cite{IM}. They proved that the homomorphisms are injective. A particular cases of our embeddings is a theorem of Birman and Hilden that embeds the braid group on $p$ strands into the mapping class group of …
Non synonymous nucleotide polymorphisms in human taste receptors and individual taste sensitivity to glutamate
2008
National audience
Role of Cytokine Polymorphisms in the Rhinitis-Asthma Evolution
2014
AAD1. Role of Cytokine Polymorphisms in the Rhinitis-Asthma Evolution G. Santini1, L. Scola1, S. La Piana1, P. Di Gangi1, L. Vaccarino1, M. Bova1, C. R. Balistreri1, D. Lio1, G. Di Lorenzo1 1University of Palermo, Palermo, Italy Background: Several epidemiological studies demonstrate that a timeline from rhinitis to asthma exists, and that rhinitis is a risk factor for asthma. In particular, rhinitis increases the chance of development of asthma by about three times. In addition to environmental factors, genetic factors play an important role in the development of atopic airway diseases. The aim of this study is to analyse the role of cytokine polymorphism in the evolution of rhinitis-asthm…
Type 1 Diabetes and Autoimmune Thyroid Disease—The Genetic Link
2021
Type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) are the most frequent chronic autoimmune diseases worldwide. Several autoimmune endocrine and non-endocrine disorders tend to occur together. T1D and AITD often cluster in individuals and families, seen in the formation of autoimmune polyendocrinopathy (AP). The close relationship between these two diseases is largely explained by sharing a common genetic background. The HLA antigens DQ2 (DQA1*0501-DQB1*0201) and DQ8 (DQA1*0301-DQB1*0302), tightly linked with DR3 and DR4, are the major common genetic predisposition. Moreover, functional single nucleotide polymorphisms (or rare variants) of various genes, such as the cytotoxic T-lym…
12q21 Interstitial Deletions: Seven New Syndromic Cases Detected by Array-CGH and Review of the Literature.
2022
Interstitial deletions of the long arm of chromosome 12 are rare, with a dozen patients carrying a deletion in 12q21 being reported. Recently a critical region (CR) has been delimited and could be responsible for the more commonly described clinical features, such as developmental delay/intellectual disability, congenital genitourinary and brain malformations. Other, less frequent, clinical signs do not seem to be correlated to the proposed CR. We present seven new patients harboring non-recurrent deletions ranging from 1 to 18.5 Mb differentially scattered across 12q21. Alongside more common clinical signs, some patients have rarer features such as heart defects, hearing loss, hypotonia an…