Search results for "Mortality"

showing 10 items of 1406 documents

Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies

2012

Background— Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. Methods and Results— Continuous ABI and PAD (ABI ≤0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the ≈2.5 million single nucleotide polymorphisms (SNPs) in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fi…

Malegenetic associationGenome-wide association studyAetiology screening and detection [ONCOL 5]030204 cardiovascular system & hematologyBioinformaticsCohort Studies0302 clinical medicineRisk FactorsGenotypeCARDIOVASCULAR RISK-FACTORSInternational HapMap ProjectGenetics (clinical)POPULATIONGeneticsAged 80 and overPeripheral Vascular Diseases0303 health scienceseducation.field_of_studyAge FactorsMiddle AgedPhenotypeperipheral vascular diseaseMeta-analysiscardiovascular system/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingCORONARY-ARTERY-DISEASEFemaleCardiology and Cardiovascular MedicineChromosomes Human Pair 9AdultSUSCEPTIBILITY LOCIGenotypePopulationHapMap ProjectBiologyPolymorphism Single NucleotideArticleMolecular epidemiology [NCEBP 1]03 medical and health sciencesSex FactorsSDG 3 - Good Health and Well-beingGeneticscohort studyHumansAnkle Brachial Indexcardiovascular diseasesAlleleeducationHealth aging / healthy living Cardiovascular diseases [IGMD 5]AllelesMolecular epidemiology Aetiology screening and detection [NCEBP 1]030304 developmental biologyGenetic associationAgedCyclin-Dependent Kinase Inhibitor p15ABDOMINAL AORTIC-ANEURYSMcohort study ; genetic association ; genome-wide association study ; meta-analysis ; peripheral vascular diseasegenome-wide association studyMORTALITYChromosomeGENEmeta-analysisbody regionsLogistic ModelsMYOCARDIAL-INFARCTIONATHEROSCLEROSISSEQUENCE VARIANThuman activities
researchProduct

COVID-19 and non–COVID-19 pneumonia: a comparison

2021

Abstract Background The COVID-19 pandemic has caused the relocation of huge financial resources to departments dedicated to infected patients, at the expense of those suffering from other pathologies. Aim To compare clinical features and outcomes in COVID-19 pneumonia and non-COVID-19 pneumonia patients. Patients and methods 53 patients (35 males, mean age 61.5 years) with COVID-19 pneumonia and 50 patients (32 males, mean age 72.7 years) with non-COVID-19 pneumonia, consecutively admitted between March and May 2020 were included. Clinical, laboratory and radiological data at admission were analyzed. Duration of hospitalization and mortality rates were evaluated. Results Among the non-COVID…

Maleground-glass opacitiesmedicine.medical_specialtypolmonitePneumonia ViralPopulationmortalitàComorbidityDiseaseresourceelderlyInternal medicinePandemicPulmonary MedicinemedicineHumanspneumoniahealth systemeducationPandemicsDisease burdenopacità a vetro smerigliatoRetrospective StudiesAgededucation.field_of_studybusiness.industrySARS-CoV-2Mortality raterisorseCOVID-19General MedicineMiddle Agedmedicine.diseaseComorbiditymortalityPneumoniaground-glass opacitieCOVID-19 Nucleic Acid TestingHRCTricoverianzianiresourcesbusinesssistema sanitarioResearch ArticleKidney diseasehospitalization
researchProduct

Effects of a 12‐month home‐based exercise program on functioning after hip fracture – Secondary analyses of an RCT

2022

Background Long-term functional limitations are common after hip fractures. Exercise may alleviate these negative consequences but there is no consensus on an optimal training program. The objective was to study the effects of a 12-month home-based supervised, progressive exercise program on functioning, physical performance, and physical activity. Methods Secondary analysis of a randomized controlled trial targeting patients with surgical repair of a hip fracture, aged >= 60 years, Mini-Mental State Examination (MMSE) score of >= 12. The participants were randomized into Exercise (n = 61) or Usual care (n = 60). Assessments at baseline, 3, 6, and 12 months included Lawton's Instrumental Ac…

Malehome-based exercisefyysinen toimintakykyleikkaushoitofunctioningREHABILITATION PROGRAMSTRENGTHActivities of Daily LivingHumansOLDER-ADULTSPREDICTORSluunmurtumatlääkinnällinen kuntoutusPhysical Therapy ModalitiesAged 80 and overOUTCOMESHand StrengthHip FracturesMORTALITYphysical performanceRECOVERYlonkkaExercise TherapyPHYSICAL-ACTIVITYMOBILITYhip fracture3121 General medicine internal medicine and other clinical medicineINSTRUMENTAL ACTIVITIESFemaleGeriatrics and GerontologyikääntyneetliikuntahoitoJournal of the American Geriatrics Society
researchProduct

Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome

2014

Background: Abdominal infections are frequent causes of sepsis and septic shock in the intensive care unit (ICU) and are associated with adverse outcomes. We analyzed the characteristics, treatments and outcome of ICU patients with abdominal infections using data extracted from a one-day point prevalence study, the Extended Prevalence of Infection in the ICU (EPIC) II.Methods: EPIC II included 13,796 adult patients from 1,265 ICUs in 75 countries. Infection was defined using the International Sepsis Forum criteria. Microbiological analyses were performed locally. Participating ICUs provided patient follow-up until hospital discharge or for 60 days.Results: Of the 7,087 infected patients, 1,…

Malehumanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]Settore MED/41 - AnestesiologiaGUIDELINESlaw.inventionsepsislawAbdomenabdominal infections; crtitical carePrevalenceMedicine and Health SciencesMedicinePathologie maladies infectieusesAbdomen; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Critical Illness; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Prevalence; Sepsis; Treatment Outcome; Young Adult; Intensive Care Units; Infectious Diseasesmediana edadMedicine(all)ancianoAbdominal Infection Sepsis Epic IIresultado del tratamientoprevalenciaBacterial InfectionsMiddle AgedadultoAbdominal infectionIntensive care unitAbscessAnti-Bacterial AgentsPREVALENCEadulto jovenIntensive Care UnitsTreatment OutcomeInfectious Diseasesmedicine.anatomical_structureSAPS IIAbdominal infection ; Abscess ; Peritonitis ; Severe sepsis ; Critical care ; Antibiotic therapy ; MicrobiologyFemaleSOFA score10023 Institute of Intensive Care MedicineantibacterianosResearch ArticleAdultmedicine.medical_specialtyCritical Illnessunidades de cuidados intensivosenfermedad críticaPeritonitis610 Medicine & healthNOSOCOMIAL INTRAABDOMINAL INFECTIONSPeritonitisMicrobiologySepsisYoung AdultMORBIDITYInternal medicineMANAGEMENTHumansAgedCANDIDASEPSISbusiness.industrySeptic shockMORTALITYAbdominal InfectionADULTS2725 Infectious DiseasesAntibiotic therapymedicine.diseaseSevere sepsisSurgeryCritical careCross-Sectional Studiesinfecciones bacterianasAbdomenbusinessestudios transversales
researchProduct

Prognostic Impact of Hyponatremia and Hypernatremia in COVID-19 Pneumonia. A HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19) Regist…

2020

Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admittance dysnatremia is associated with mortality, sepsis, or intensive therapy (IT) in patients hospitalized with SARS-COV2 pneumonia. This is a retrospective study of the HOPE-COVID-19 registry, with data collected from January 1th through April 31th, 2020. We selected all hospitalized adult patients with RT-PCR-confirmed SARS-COV2 pneumonia and a registered admission serum sodium level (SNa). Patients were classified as hyponatremic (SNa <…

MalehyponatremiaEndocrinology Diabetes and Metabolism030204 cardiovascular system & hematologyGlobal Healthlcsh:Diseases of the endocrine glands. Clinical endocrinology:Health Care::Health Care Quality Access and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Outcome and Process Assessment (Health Care) [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]sepsis0302 clinical medicineEndocrinology:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Retrospective Studies [Medical Subject Headings]HiponatremiaOutcome Assessment Health CareSARS-COV2Hospital MortalityRegistriesOriginal Research:Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings]HypernatremiahypernatremiaMiddle AgedPrognosisVirusHospitalizationSurvival Rate:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization [Medical Subject Headings]HipernatremiaFemaleHyponatremiaHyponatremiamedicine.medical_specialty:Information Science::Information Science::Data Collection::Vital Statistics::Mortality::Survival Rate [Medical Subject Headings]Coronavirus disease 2019 (COVID-19)Infecciones por coronavirus:Check Tags::Male [Medical Subject Headings]030209 endocrinology & metabolismSepsis03 medical and health sciencesInternal medicineSepsis:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings]medicineHumans:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Water-Electrolyte Imbalance::Hypernatremia [Medical Subject Headings]MortalitySurvival rateAgedRetrospective Studieslcsh:RC648-665business.industrySARS-CoV-2COVID-19Retrospective cohort study:Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Aparato respiratoriomedicine.diseasemortality:Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings]Clinical trialbody regionsPneumonia:Check Tags::Female [Medical Subject Headings]:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Water-Electrolyte Imbalance::Hyponatremia [Medical Subject Headings]Mortalidad:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Hospital Mortality [Medical Subject Headings]HypernatremiabusinessFollow-Up Studies
researchProduct

Incidence of Kidney Replacement Therapy and Subsequent Outcomes Among Patients With Systemic Lupus Erythematosus: Findings From the ERA Registry.

2022

RATIONALE AND OBJECTIVE: There is a dearth of data characterizing patients requiring kidney replacement therapy (KRT) for kidney failure due to systemic lupus erythematosus (SLE) and their clinical outcomes. The aim of this study was to describe trends in incidence and prevalence of KRT among these patients as well as to compare their outcomes to patients treated with KRT for diseases other than SLE.STUDY DESIGN: Retrospective cohort study based on kidney registry data.SETTING & PARTICIPANTS: Patients recorded in 14 registries of patients receiving kidney replacement therapy that provided data to the European Renal Association (ERA) Registry between 1992 and 2016.PREDICTOR: SLE as cause…

Malekidney diseasemedicine.medical_treatmentMAINTENANCE DIALYSIS030232 urology & nephrologyLupus nephritislupus nephritis (LN)0302 clinical medicineLupus Erythematosus Systemickidney replacement therapy (KRT)RegistriesRenal InsufficiencyKidney transplantationRISKeducation.field_of_studyKidneyregistry studyIncidence (epidemiology)IncidenceSTAGE RENAL-DISEASELupus Nephritis3. Good healthEuropeRenal Replacement Therapymedicine.anatomical_structureNephrologySURVIVALFemalemedicine.medical_specialtyprevalencePopulationkidney transplantationUNITED-STATESsurvival03 medical and health sciencesAFRICAN-AMERICAN PATIENTSInternal medicinemedicineHumansESRDeducationNEPHRITISDialysisRetrospective Studies030203 arthritis & rheumatologyProportional hazards modelbusiness.industryTRANSPLANTATIONMORTALITYRetrospective cohort studymedicine.diseasekidney failureend-stage renal disease (ESRD)3121 General medicine internal medicine and other clinical medicineSystemic lupus erythematosus (SLE)Kidney Failure ChronicprognosisbusinessAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
researchProduct

Living alone vs. living with someone as a predictor of mortality after a bone fracture in older age

2020

Abstract Background Living alone is a risk factor for health decline in old age, especially when facing adverse events increasing vulnerability. Aim We examined whether living alone is associated with higher post-fracture mortality risk. Methods Participants were 190 men and 409 women aged 75 or 80 years at baseline. Subsequent fracture incidence and mortality were followed up for 15 years. Extended Cox regression analysis was used to compare the associations between living arrangements and mortality risk during the first post-fracture year and during the non-fracture time. All participants contributed to the non-fracture state until a fracture occurred or until death/end of follow-up if th…

MalekuolleisuusAgingsosiaalinen tukiSocial networksSocial support03 medical and health sciencesSocial supportFractures Bone0302 clinical medicinesosiaaliset verkostotResidence CharacteristicsRisk FactorsmedicineHumans030212 general & internal medicineRisk factorAdverse effectliving arrengementAgedAged 80 and overresilienssiHealth stressors030214 geriatricsResilienceGeriatrics gerontologyProportional hazards modelbusiness.industryIncidence (epidemiology)IncidenceasuminenBone fracturemedicine.diseaseLiving arrangementFemaleOriginal ArticleGeriatrics and GerontologybusinessLower mortalityhealth stressorsikääntyneetDemographyAging Clinical and Experimental Research
researchProduct

Handgrip strength is inversely associated with fatal cardiovascular and all-cause mortality events

2020

Purpose: We aimed to assess the associations of handgrip strength (HS) with cardiovascular and all-cause mortality and whether adding data on HS to cardiovascular disease (CVD) risk factors is associated with improvement in CVD mortality prediction. Design: Handgrip strength was assessed in a population-based sample of 861 participants aged 61–74 years at baseline. Relative HS was obtained by dividing the absolute value by body weight. Results: During a median (interquartile range) follow-up of 17.3 (12.6–18.4) years, 116 fatal coronary heart diseases (CHDs), 195 fatal CVDs and 412 all-cause mortality events occurred. On adjustment for several risk factors, the hazard ratios (95% confidence…

Malekuolleisuusmedicine.medical_specialtyHealth StatuspuristusvoimaDisease030204 cardiovascular system & hematology03 medical and health sciencesrisk prediction0302 clinical medicinecardiovascular diseaseInternal medicineMedicineHumans030212 general & internal medicineLongitudinal StudiesProspective StudiesAgedhandgrip strengthHand Strengthbusiness.industryGeneral MedicineOriginal ArticlesriskinarviointimortalityCardiovascular DiseasesHeart Disease Risk FactorsCardiologysydän- ja verisuonitauditFemalebusinessAll cause mortality
researchProduct

Environmental barriers, person-environment fit and mortality among community-dwelling very old people

2013

Background. Environmental barriers are associated with disability-related outcomes in older people but little is known of the effect of environmental barriers on mortality. The aim of this study was to examine whether objectively measured barriers in the outdoor, entrance and indoor environments are associated with mortality among community-dwelling 80- to 89-year-old single-living people. Methods. This longitudinal study is based on a sample of 397 people who were single-living in ordinary housing in Sweden. Participants were interviewed during 2002–2003, and 393 were followed up for mortality until May 15, 2012. Environmental barriers and functional limitations were assessed with the Hous…

Malekuolleisuusmedicine.medical_specialtyLongitudinal studyympäristöFrail Elderlyyksilö-ympäristö yhteensopivuusEnvironmentStairsEnvironmental healthEpidemiologymedicineHumansENABLE AGE-projectMobility LimitationMortalityEnablerProportional Hazards ModelsAged 80 and overSwedenbusiness.industryProportional hazards modelPublic healthPublic Health Environmental and Occupational HealthArchitectural AccessibilityPublic Health Global Health Social Medicine and EpidemiologyHousing for the ElderlyHousing EnablerPerson–environment fitHousingFemaleHousing for the ElderlyBiostatisticsOlder peoplebusinessResearch Article
researchProduct

Global electrical heterogeneity as a predictor of cardiovascular mortality in men and women

2018

Aims The aim of this study was to investigate the contribution of depolarization and repolarization abnormalities, specially abnormalities in global electrical heterogeneity of heart in cardiovascular disease (CVD) and all-cause mortality. Methods and results Eight hundred and forty men and 911 women, average age of 63 years participated in this study with average follow-up was 14 years. Six electrocardiogram/vector electrocardiogram (ECG/VECG) markers QRS-duration, QTc-interval, QRST-angle, sum of absolute QRST integral (SAI QRST), T-wave roundness, and TV1-amplitude were estimated from VECG measurements. Hazard ratios (HRs) for CVD events (164 deaths) and all-cause mortality (383 deaths) …

Malekuolleisuusmedicine.medical_specialtyglobal electrical heterogeneityVectorcardiography030204 cardiovascular system & hematologyelectrocardiogramQT intervalRESTING HEART RATERisk Assessment03 medical and health sciencesElectrocardiography0302 clinical medicineSex FactorsRisk Factorscardiovascular diseasecardiovascular mortalityQRST-anglePhysiology (medical)Internal medicinemedicineMale populationRepolarizationHumanscardiovascular diseases030212 general & internal medicineEKGFinlandCardiovascular mortalitybusiness.industryHazard ratiota3142riskitekijätMiddle Agedta3121Confidence intervalElectrophysiological PhenomenaCardiovascular DiseasesRisk stratificationCardiologysydän- ja verisuonitauditFemaleseurantatutkimusCardiology and Cardiovascular MedicinebusinessEuropace
researchProduct