Search results for "Moth"
showing 10 items of 2617 documents
Antineoplastic dosing in overweight and obese cancer patients: an Associazione Italiana Oncologia Medica (AIOM)/Associazione Medici Diabetologi (AMD)…
2021
Most anticancer molecules are administered in body-size-based dosing schedules, bringing up unsolved issues regarding pharmacokinetic data in heavy patients. The worldwide spread of obesity has not been matched by improved methods and strategies for tailored drug dosage in this population. The weight or body surface area (BSA)-based approaches may fail to fully reflect the complexity of the anthropometric features besides obesity in cancer patients suffering from sarcopenia. Likewise, there is a lack of pharmacokinetic data on obese patients for the majority of chemotherapeutic agents as well as for new target drugs and immunotherapy. Therefore, although the available findings point to the …
The role of mothers' beliefs in students' self-concept of ability development
2018
The aim of this study was to investigate whether the child-related competence beliefs of mothers are associated with the development of Finnish adolescents' self-concept of mathematics and literacy ability during their transition from primary to lower secondary school and whether these associations depend on adolescents' level of performance. The results showed that, first, adolescents' self-concept of mathematics and literacy ability decreased over time. The impact of maternal beliefs on the linear trend of the self-concept of mathematics and literacy ability was dependent on the level of students' performance. Mothers' high beliefs buffered against the decrease in adolescents' self-concep…
Randomized trial of primary debulking surgery versus neoadjuvant chemotherapy for advanced epithelial ovarian cancer (SCORPION-NCT01461850)
2020
ObjectiveTo investigate whether neoadjuvant chemotherapy followed by interval debulking surgery is superior to primary debulking surgery in terms of perioperative complications and progression-free survival, in advanced epithelial ovarian, fallopian tube or primary peritoneal cancer patients with high tumor load.MethodsPatients with advanced epithelial ovarian, fallopian tube or primary peritoneal cancer (stage IIIC-IV) underwent laparoscopy. Patients with high tumor load assessed by a standardized laparoscopic predictive index were randomly assigned (1:1 ratio) to undergo either primary debulking surgery followed by adjuvant chemotherapy (arm A), or neoadjuvant chemotherapy followed by int…
The role of parents' and teachers' child-related competence beliefs in the development of students' self-concept of ability
2017
Individuals’ perceptions about their abilities, that is, self-concepts of abilities, are crucial determinants of academic achievement and education-related choices. The aims of this research were to examine the role of parents’ and teachers’ beliefs about children’s abilities in students’ self-concept of ability in the domains of literacy and mathematics, and whether the role of parents and teachers is different among boys and girls, and among low- and high-performing students. These questions were examined using three different data sets: the LIGHT study, the Jyväskylä Entrance into Primary School (JEPS) study and the STAIRWAY study. In all three studies, the participants were Finnish. In …
Kielellisiä taitoja ja koulunkäyntivalmiuksia : valmistavan opetuksen ja oman äidinkielen opetuksen tila ja vaikuttavuus -arviointi
2022
Tässä raportissa tarkastellaan Kansallisen koulutuksen arviointikeskuksen (Karvin) toteuttaman kansallisen arvioinnin tuloksia perusopetukseen valmistavan opetuksen ja oppilaan oman äidinkielen opetuksen tilasta ja vaikuttavuudesta. Arviointi kohdistuu erityisesti opetuksen tavoitteiden toteutumiseen ja opetuksen järjestämistapoihin. Lisäksi selvitetään opetusta ja oppimista edistäviä ja estäviä tekijöitä. Arviointi tuottaa tietoa hallituksen Oikeus oppia -kehittämisohjelmaan. Ohjelman tavoitteena on laatia toimenpiteitä, joilla turvataan maahanmuuttotaustaisten lasten ja nuorten oppimisedellytykset ja koulutussiirtymät etenkin koulutuksen nivelvaiheissa. Arviointiin osallistui 73 opetuksen…
LH administration as a potential strategy for ovarian protection and female fertility preservation against highly gonadotoxic chemotherapy
2022
Els ovaris contenen una reserva de fol·licles no renovable, que produeixen un únic ovòcit fecundable a cada cicle menstrual al llarg de l'etapa reproductiva femenina (15-49 anys), però que disminueix progressivament amb l'edat. Per tant, els factors que afecten negativament la dotació de fol·licles provocaran una reducció significativa de la vida reproductiva en la dona. Les teràpies oncològiques basades en l'administració de quimioteràpia alquilant s'utilitzen habitualment per a tractar els càncers ginecològics en pacients joves, però amb freqüència acceleren l'esgotament de la reserva fol·licular i l'aparició de la menopausa. Els efectes secundaris de la quimioteràpia sobre la fertilitat,…
[1,2]oxazole[5,4-e]isoindoles as promising drugs for anticancer chemotherapy
2015
Parenthood and changes in physical activity from early adulthood to mid‐life among Finnish adults
2022
This study examined longitudinal associations between parenthood-related factors and physical activity from young adulthood to midlife over a 19-year follow-up period. Participants (n=761) at the ongoing Cardiovascular Risk in Young Finns Study responded to a self-report questionnaire in their adulthood (in 1992, 2001, 2007 and 2011). Participants were classified as meeting or not meeting an aerobic physical activity recommendation. Parenthood related factors included the age of having their first child, as well as the number and age of the children. Analyses of Generalized Estimation Equations were performed and adjusted for several demographic and health-related covariates. Both mothers a…
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) for Unresectable Peritoneal Metastases. Feasibility, Safety and Efficacy Outcomes
2022
Recently, a novel method for chemotherapy administration inside the abdominal cavity gained wide attention among surgical oncologists dealing with peritoneal surface malignancies. Based on laparoscopy, Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a drug delivery system designed to overcome the known hurdles of intraperitoneal chemotherapy. Preclinical data suggest that the aerosol drug that PIPAC creates and the increased intraabdominal pressure obtained during laparoscopy provide highly effective distribution of cytotoxic compounds into tumor nodules. Several studies have documented the favorable safety profile and promising clinical outcomes of repetitive PIPAC in different…