Search results for "Mphi"

Anatectic amphibole and restitic garnet in Variscan migmatite from NE Sardinia, Italy: insights into partial melting from mineral trace elements

2014

We report results of a laser-ICP-MS investigation of trace element contents in the main constituent minerals of an amphibole-bearing migmatite from the Variscan orogen in northeastern Sardinia. The migmatite is associated with migmatised orthogneiss and Al-silicate-bearing pelitic migmatites. The protolith of the amphibole-bearing migmatite was a mid-Ordovician igneous rock of intermediate composition characterised by a biotite + plagioclase + quartz assemblage. The migmatite consists of mesosomes and tonalitic (or, less frequently, granodioritic) leucosomes, characterised by amphibole crystals (potassian ferropargasite) up to 2 cm in size. The tonalitic leucosomes are made up of quartz, pl…

Long-term response of marine benthic fauna to thin-layer capping with powdered activated carbon in the Grenland fjords, Norway

2021

The Grenland fjords in Norway have a long history of contamination by large emissions of dioxins and mercury. As a possible sediment remediation method in situ, thin-layer capping with powdered activated carbon (AC) mixed with clay was applied at two test sites at 30 m and 95 m depth in the Grenland fjords. This study presents long-term effects of the AC treatment on the benthic community structure, i.e. nine years after capping. Capping with AC significantly reduced the number of species, their abundance and biomass at the two test sites, compared to uncapped reference sites. At the more shallow site, the dominant brittle star species Amphiura filiformis disappeared shortly after capping a…

Further evidence of length- and sex-dependent variation of some morphological characters in Bathyporeia guilliamsoniana (Bate, 1857) (Crustacea: Amph…

2011

Synthesis and Antibody Binding of Highly Fluorinated Amphiphilic MUC1 Glycopeptide Antigens

2011

The analysis of humoral immune responses is of great importance for basic and clinical research. Mapping the structural requirements of epitope recognition with modified tumor-associated carbohydrate antigens allows both the development of biomarkers and the design of synthetic anticancer vaccines. For this purpose, double-tailed hydrocarbon/fluorocarbon membrane anchors have been prepared and conjugated to a TN dipeptide. Furthermore, a novel hydrophobized MUC1 tandem repeat glycopeptide antigen was fully assembled on a solid support and its specific binding to different mouse anti-MUC1 antibodies was demonstrated through ELISA, QCM, and SPR measurements. Such functional fluorous MUC1 anti…

Cytotoxicity and chemosensitizing activity of amphiphilic poly(glycerol)-poly(alkylene oxide) block copolymers.

2014

All polymeric chemosensitizers proposed thus far have a linear poly(ethylene glycol) (PEG) hydrophilic block. To testify whether precisely this chemical structure and architecture of the hydrophilic block is a prerequisite for chemosensitization, we tested a series of novel block copolymers containing a hyperbranched polyglycerol segment as a hydrophilic block (PPO-NG copolymers) on multi-drug-resistant (MDR) tumor cells in culture. PPO-NG copolymers inhibited MDR of three cell lines, indicating that the linear PEG can be substituted for a hyperbranched polyglycerol block without loss of the polymers' chemosensitizing activity. The extent of MDR reversal increased with the polymers affinity…

Orthogonal Click Conjugation to the Liposomal Surface Reveals the Stability of the Lipid Anchorage as Crucial for Targeting

2016

Synthetic access to multiple surface decorations are a bottleneck in the development of liposomes for receptor mediated targeting. This opens a complex multiparameter space, exploration of which is severely limited in terms of sample numbers and turnaround times. Here, we unlock this technological barrier by a combination of a milligram-scale liposome formulation using dual centrifugation and orthogonal click chemistry on the liposomal surface. Application of these techniques to conceptually new amphiphilic compounds, which feature norbornene and alkyne groups at the apex of sterically stabilizing, hyperbranched polyglycerol moieties, revealed a particular influence of the membrane anchor o…

Hydrophobicity of bacteria Zymomonas mobilis under varied environmental conditions

2007

Abstract Changes in the cell surface hydrophobicity (CSH) of bacteria Zymomonas mobilis 113S were examined in response to varied environmental conditions (temperature and phase of growth, concentration or type of carbon source, the presence of amphiphilic compounds). The values of CSH were elevated with a decreased growth rate over the time of cultivation up to 20–22% at the stationary phase. CSH values increased proportionally with the growth of cultivation temperature and concentration of carbon source (glucose or sucrose) or amphiphilic compound (aliphatic alcohols, Tween80) in the medium. Replacement of sucrose by glucose and the presence of Tween20 in the growth medium resulted in redu…

Unusual basement layer in the midgut of gammaridean Niphargus virei Chevreux (Crustacea, Amphipoda).

1988

The basement membrane of the midgut and posterior caeca epithelium in the gammaridean amphipod Niphargus virei Chevreux, 1896 is made of an unusual structure. This basal lamina, properly called “basal layer”, shows a dense sheet formed by a system of dense hexagonal plates connected by thin filaments. Histochemical studies and enzymatic reactions lead to the conclusion that these structures are proteinaceous, without collagenous protein, and embedded in a neutral polysaccharide matrix. The possible mechanical significance of these mesenteric structures is discussed.

Anatomie microscopique de l'involution des troncs branchiaux des amphibiens

1938

Izvilkums no: Archives d'anatomie, d'histologie et d'embryologie normales et expérimentales, t. xxv, 1938, p. 1-64.

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

2014

This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed with stealth like behavior and excellent physicochemical stability. Inulin was firstly modified in the side chain with primary amine groups, followed in turn by conjugation with squalenoyl derivatives through common amidic coupling agents and PEGylation by imine linkage. Polymer coated SPIONs were so obtained by spontaneous self-assembling of inulin copolymer onto magnet…