Search results for "Multicenter study"

showing 10 items of 211 documents

Liver Preservation by Aortic Perfusion Alone Compared With Preservation by Aortic Perfusion and Additional Arterial Ex Situ Back-Table Perfusion With…

2017

Background. Arterial ex situ back-table perfusion (BP) reportedly reduces ischemic-type biliary lesion after liver transplantation. We aimed to verify these findings in a prospective investigation. Methods. Our prospective, randomized, controlled, multicenter study involved livers retrieved from patients in 2 German regions, and compared the outcomes of standard aortic perfusion to those of aortic perfusion combined with arterial ex situ BP. The primary endpoint was the incidence of ischemic-type biliary lesions over a follow-up of 2 years after liver transplantation, whereas secondary endpoints included 2-year graft survival, initial graft damage as reflected by transaminase levels, and fu…

Transplantationmedicine.medical_specialtyHistidine-tryptophan-ketoglutarate solutionbusiness.industrymedicine.medical_treatmentlcsh:SurgeryMedizinlcsh:RD1-811030230 surgeryLiver transplantation019Liver TransplantationLesion03 medical and health sciences0302 clinical medicineMulticenter studyInternal medicinemedicineCardiology030211 gastroenterology & hepatologymedicine.symptombusinessLiver preservationPerfusion
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Association between osteocalcin and cognitive performance in healthy older adults.

2016

INTRODUCTION: cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.METHODS: this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor …

cognitionMaleAgingosteopontinvery elderlyCognitive declinesclerostinNeuropsychological Testsolder peopleExecutive FunctionAbsorptiometry PhotonBone Densityblood analysiscognitive defectphoton absorptiometry80 and overcalcium blood leveldickkopf 1 protein25 hydroxyvitamin D; calcium; dickkopf 1 protein; fibroblast growth factor 23; osteocalcin; osteopontin; osteoprotegerin; parathyroid hormone; sclerostin; biological marker; osteocalcin adult; aged; Article; blood analysis; bone density; bone remodeling; calcium blood level; cognition; controlled study; cross-sectional study; dual energy X ray absorptiometry; episodic memory; executive function; female; human; male; neuropsychological test; priority journal; working memory; adolescent; age; aging; blood; clinical trial; cognitive aging; cognitive defect; comparative study; Europe; metabolic bone disease; multicenter study; photon absorptiometry; psychology; sex difference; short term memory; very elderly; young adult Absorptiometry Photon; Adolescent; Adult; Age Factors; Aged; Aged 80 and over; Aging; Biomarkers; Bone Density; Bone Diseases Metabolic; Bone Remodeling; Cognition; Cognition Disorders; Cognitive Aging; Cross-Sectional Studies; Europe; Executive Function; Female; Humans; Male; Memory Episodic; Memory Short-Term; Neuropsychological Tests; Osteocalcin; Sex Factors; Young Adult; Ageing; Cognitive decline; Older people; Osteocalcincomparative studyAged 80 and overdual energy X ray absorptiometryadultAge Factorsclinical trialepisodic memorybiological markerPhotonEuropeagedMemory Short-Termfemalepriority journalyoung adultmetabolic bone diseaseBone RemodelingBone DiseasesEpisodicResearch PaperAdolescentMemory Episodicsex differenceOsteocalcinosteocalcinpsychologyArticleworking memoryfibroblast growth factor 23short term memorySex FactorsbloodMemoryparathyroid hormonecross-sectional studyHumanscontrolled studyhumanAbsorptiometrycalciumcognitive agingcognitive declineBone Diseases MetabolicAgeingikääntyminen25 hydroxyvitamin Dmulticenter studyCross-Sectional StudiesageShort-Termosteoprotegerinneuropsychological testMetabolicOlder peopleCognition DisordersBiomarkers
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Histologic analysis of specimens from laparoscopic endometrioma excision performed by different surgeons: does the surgeon matter?

2011

Objective To evaluate whether the amount of ovarian tissue inadvertently removed along with the endometrioma cyst wall at laparoscopy differs in relation to the operating surgeon's level of expertise. Design Multicenter, prospective trial. Setting Four tertiary care university hospitals. Patient(s) Fifty patients, aged 25 to 40 years, with monolateral ovarian endometriomas who underwent laparoscopic excision. Intervention(s) Operation with the stripping technique by surgeons with specific expertise in endometriosis surgery in four centers (groups A, B, C, and D) and by residents with average training in laparoscopic surgery (group E). Main Outcome Measure(s) Histologic examination for the e…

endometriosisLaparoscopic surgerymedicine.medical_treatmentEndometriosisEndometriosis laparoscopy ovarian cystsGynecologic Surgical Proceduresmorphologyovarian endometriomaMedicineSingle-Blind MethodOvarian DiseasesLaparoscopyclinical articleresidency educationmedicine.diagnostic_testmedical specialistarticleObstetrics and Gynecologyendometriosis; laparoscopy; ovarian cystsOrgan Sizelaparoscopic surgeryTumor Burdenendometrium tumorfemaleuterus surgerymedicine.anatomical_structurepriority journalstripping techniquehistopathologyClinical CompetenceAdultmedicine.medical_specialtyOvaryPhysiciansHumanshumanOvarian cystbusiness.industryOvaryHistologymedicine.diseasehuman tissuethicknessSurgeryEndoscopyadult; article; clinical article; endometriosis; endometrium tumor; female; histopathology; human; human tissue; laparoscopic surgery; medical specialist; morphology; multicenter study; ovarian endometrioma; ovary; priority journal; residency education; stripping technique; surgeon; thickness; uterus surgery Adult; Clinical Competence; Endometriosis; Female; Gynecologic Surgical Procedures; Humans; Laparoscopy; Organ Size; Ovarian Diseases; Ovary; Physicians; Single-Blind Method; Tumor Burdenmulticenter studySettore MED/40 - GINECOLOGIA E OSTETRICIAReproductive MedicinesurgeonLaparoscopyHistopathologybusiness
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Subjective photic phenomena with refractive multifocal and monofocal intraocular lenses. results of a multicenter questionnaire.

2001

Abstract Purpose To compare the incidence and severity of photic phenomena after the implantation of the Array® (Allergan) refractive multifocal intraocular lens (MIOL) and a monofocal IOL. Setting Multicenter study at Kiel, Mainz, Karlsruhe, and Bremerhaven, Germany. Methods The study comprised 231 randomly selected patients from 4 study centers. The patients had had uneventful phacoemulsification with implantation of a refractive MIOL (n = 138) or a monofocal IOL (n = 93). By questionnaire, patients were asked whether they experienced light sensations postoperatively (light streaks, halos, flare, flashes, or glare) that had not been noticed preoperatively. Additional questions evaluated w…

genetic structuresLightmedicine.medical_treatmentEye diseaseVision DisordersIntraocular lensGlareVision disorderLens Implantation IntraocularSurveys and QuestionnairesmedicineHumansLenses IntraocularPhacoemulsificationbusiness.industryIncidenceGlare (vision)PhacoemulsificationMultifocal intraocular lensCataract surgerymedicine.diseaseeye diseasesSensory SystemsOphthalmologyMulticenter studyOptometrySurgerysense organsmedicine.symptombusinessJournal of cataract and refractive surgery
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Allergic sensitization to common pets (cats/dogs) according to different possible modalities of exposure: an Italian Multicenter Study

2018

Abstract Background The query “are there animals at home?” is usually administered for collecting information on anamnesis. This modality to consider exposure to pet allergens constitutes a potential bias in epidemiological studies and in clinical practice. The aim of our study was to evaluate/quantify different modalities of exposure to cat/dog in inducing allergic sensitization. Methods Thirty Italian Allergy units participated in this study. Each centre was required to collect the data of at least 20 consecutive outpatients sensitized to cat/dog allergens. A standardized form reported all demographic data and a particular attention was paid in relieving possible modalities of exposure to…

lcsh:Immunologic diseases. AllergyAllergymedicine.medical_specialtyImmunologySettore MED/10 - Malattie Dell'Apparato RespiratorioPets exposureAllergic rhinitisAllergic sensitization03 medical and health sciences0302 clinical medicineInternal medicineEpidemiologyAllergic rhinitiDogHypersensitivitymedicineImmunology and Allergy030212 general & internal medicineAllergic rhinitis Allergic sensitization Bronchial asthma Cat; Dog Hypersensitivity Pets Pets exposure Immunology and Allergy Immunology Molecular BiologyBronchial asthmaMolecular BiologyAllergic rhinitis; Allergic sensitization; Bronchial asthma; Cat; Dog; Hypersensitivity; Pets; Pets exposureAllergic sensitizationAnamnesisCATSModalitiesbusiness.industryResearchCatPetsmedicine.diseasePet ownershipPet030228 respiratory systemMulticenter studyAllergic rhinitis; Allergic sensitization; Bronchial asthma; Cat; Dog; Hypersensitivity; Pets; Pets exposure; Immunology and Allergy; Immunology; Molecular Biologylcsh:RC581-607businessClinical and Molecular Allergy
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Su1645 G-Eyeâ,,¢ High-Definition Colonoscopy Increases Adenoma Detection Rate - a Prospective Randomized Multicenter Study of 1000 Patients

2017

medicine.medical_specialtyAdenomamedicine.diagnostic_testbusiness.industryGastroenterologyColonoscopymedicine.diseaseMulticenter studyMedicineHigh definitionRadiology Nuclear Medicine and imagingRadiologyDetection ratebusinessGastrointestinal Endoscopy
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The pediatric endoscopy practice in Italy: A nationwide survey on behalf of the Italian society of pediatric gastroenterology, hepatology and nutriti…

2019

medicine.medical_specialtyAdolescentEndoscopy Digestive System Pediatrics Gastroenterology ItalyMEDLINENutritional StatusNationwide surveyPediatricsNOInternal medicinemedicineHumansEndoscopy Digestive SystemChildPediatric gastroenterologySocieties Medicaldigestive endoscopyPediatric endoscopyHepatologymedicine.diagnostic_testbusiness.industryGastroenterologyInfant NewbornInfantNutritional statusEndoscopyHepatologyEndoscopyMulticenter studyItalypediatric endoscopy; digestive endoscopy; gastroenterologyFamily medicineChild PreschoolHealth Care SurveysPediatric endoscopybusinessDigestive System
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Comprehensive geriatric assessment is an essential tool to support treatment decisions in elderly patients with diffuse large B-cell lymphoma: A pros…

2015

We performed a multicenter study to validate the concept that a simple comprehensive geriatric assessment (CGA) can identify elderly, non-fit patients with diffuse large B-cell lymphoma (DLBCL) in whom curative treatment is not better then palliation, and to analyze potential benefits of treatment modulation after further subdividing the non-fit category by CGA criteria. One hundred and seventy-three patients aged > 69 treated with curative or palliative intent by clinical judgement only were grouped according to CGA into fit (46%), unfit (16%) and frail (38%) categories. Two-year overall survival (OS) was significantly better in fit than in non-fit patients (84% vs. 47%; p < 0.0001).…

medicine.medical_specialtyCancer ResearchMultivariate analysisLymphomaChemotherapeutic approaches; Immunotherapy; Lymphoma and Hodgkin disease; Hematology; Oncology; Cancer ResearchMEDLINEDisease-Free SurvivalInternal medicineComprehensive Assesment Diffuse large B cell lymphomaAntineoplastic Combined Chemotherapy Protocolsmedicine80 and overLarge B-CellHumansProspective StudiesProspective cohort studyGeriatric AssessmentAgedAged 80 and overChemotherapeutic approachesbusiness.industryPalliative CareGeriatric assessmentHematologymedicine.diseasePrognosisDiffuseSurgeryLymphomaSettore MED/15 - MALATTIE DEL SANGUETreatment OutcomeMulticenter studyOncologyLymphoma and Hodgkin diseaseMultivariate AnalysisTreatment decision makingImmunotherapyLymphoma Large B-Cell DiffusebusinessDiffuse large B-cell lymphoma
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Do Degree Programs Affect Health Profession Students' Attitudes and Opinions Toward Vaccinations? An Italian Multicenter Study

2019

Abstract Background Healthcare workers' attitudes toward vaccination have been widely described in the literature, but a restricted amount of studies assessed healthcare students' knowledge, attitudes, and opinions on this issue. This study aimed to estimate the influence of a degree course on knowledge and immunization behavior among healthcare students and to compare medical students with students from other health profession degree programs to identify possible differences. Methods A multicenter, cross-sectional study was performed in 2018 in 14 Italian Universities (3,131 students were interviewed). A validated questionnaire was used to assess knowledge, attitudes, and opinions toward v…

medicine.medical_specialtyChemical Health and Safetybusiness.industryInfluenza vaccineeducationPublic Health Environmental and Occupational HealthValidated questionnaireHealth professionsAffect (psychology)Mandatory vaccinationVaccinationMulticenter studyFamily medicineHealth caremedicineSafety Risk Reliability and QualitybusinessPsychologySafety ResearchSafety and Health at Work
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<p>A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome</p…

2019

Purpose To investigate the safety and efficacy of sterile isotonic seawater washes vs standard treatment with carmellose artificial tears in dry eye syndrome (DES). Patients and methods This is a randomized multicenter prospective study with 12 weeks of follow-up. A group of patients with DES (N=60) were treated with seawater spray (Quinton®) five times daily, and another similar group (N=60) were treated with carmellose artificial tears eyedrops (Viscofresh® 0.5%) five times a day. The parameters studied and measured were as follows: Ocular Surface Disease Index questionnaire score, Schirmer I test (without anesthesia) score, tear osmolarity (TearLab®), tear breakup time, tear meniscus hei…

medicine.medical_specialtyCorneal stainingbusiness.industryStandard treatmentmedicine.medical_treatmenteye diseases03 medical and health sciencesOphthalmologyArtificial tears0302 clinical medicineMulticenter studyOphthalmology030221 ophthalmology & optometrymedicineTearsSeawaterOcular Surface Disease Indexsense organsbusinessProspective cohort study030217 neurology & neurosurgeryClinical Ophthalmology
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