Search results for "Multidisciplinar"
showing 10 items of 4692 documents
Examining the generalizability of research findings from archival data
2022
This research project benefitted from Ministry of Education (Singapore) Tier 1 Grant R-313-000-131-115 (to A. Delios), National Science Foundation of China Grants 72002158 (to H.T.) and 71810107002 (to H.T.), grants from the Knut and Alice Wallenberg Foundation (to A. Dreber) and the Marianne and Marcus Wallenberg Foundation (through a Wallenberg Scholar grant; to A. Dreber), Austrian Science Fund (FWF) Grant SFB F63 (to A. Dreber), grants from the Jan Wallander and Tom Hedelius Foundation (Svenska Handelsbankens Forskningsstiftelser; to A. Dreber), and an Research & Development (R&D) research grant from Institut Européen d'Administration des Affaires (INSEAD) (to E.L.U.). Dmitrii Dubrov, o…
La colaboración científica: principales líneas de investigación y retos de futuro
2014
The construction of knowledge is a collaborative process that has seen a dramatic growth over recent decades, since almost all research activities now involve increasing numbers of researchers, institutions, disciplines and countries. The present study provides a bibliographic review of the literature on research collaboration and identifies pioneering work on the topic, the types of studies undertaken and the variables analyzed. Several approaches are discussed: the “classical” approach, based on bibliometric indicators, which has taken on a new dimension with Social Network Analysis; and quantitative and qualitative approaches, which attempt to investigate the motivations and dynamics of …
Heart rate and other risk factors in outpatients with stable coronary artery disease in Latvia
2011
Heart rate and other risk factors in outpatients with stable coronary artery disease in Latvia The aim of the study was to characterise coronary artery disease (CAD) outpatients in Latvia by risk factors (RF) including heart rate (HR), physical examination data, clinical data and treatment. Twelve practitioners had each examined and questioned 6 to 12 patients with established CAD (n = 120). The most frequent cardiovascular (CV) RF and co-morbidity were dyslipidemia (94.2%) and hypertension (78.3%), respectively. Prevalence of increased resting HR (≥70 bpm) was 35.9% and 33.6%, when measured by pulse palpation and electrocardiography, respectively. Regarding other RFs, prevalence of treated…
Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin s…
1994
Cytotoxic necrotizing factor type 2 (CNF2) produced by Escherichia coli strains isolated from intestinal and extraintestinal infections is a dermonecrotic toxin of 110 kDa. We cloned the CNF2 gene from a large plasmid carried by an Escherichia coli strain isolated from a lamb with septicemia. Hydropathy analysis of the deduced amino acid sequence revealed a largely hydrophilic protein with two potential hydrophobic transmembrane domains. The N-terminal half of CNF2 showed striking homology (27% identity and 80% conserved residues) to the N-terminal portion of Pasteurella multocida toxin. Methylamine protection experiments and immunofluorescence studies suggested that CNF2 enters the cytosol…
Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O
2001
The pore-forming toxin streptolysin O (SLO) can be used to reversibly permeabilize adherent and nonadherent cells, allowing delivery of molecules with up to 100 kDa mass to the cytosol. Using FITC-labeled albumin, 10 5 –10 6 molecules were estimated to be entrapped per cell. Repair of toxin lesions depended on Ca 2+ -calmodulin and on intact microtubules, but was not sensitive to actin disruption or to inhibition of protein synthesis. Resealed cells were viable for days and retained the capacity to endocytose and to proliferate. The active domains of large clostridial toxins were introduced into three different cell lines. The domains were derived from Clostridium difficile B-toxin and Clo…
A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo
2015
AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…
Views of Schizophrenia Among Future Healthcare Professionals: Differences in Relation to Diagnostic Labelling, Causal Explanations, and Type of Acade…
2021
Objective: Stereotyped beliefs about schizophrenia are well-established in the society and relatively common among healthcare professionals and students. The aim of this study was to investigate the opinions about the causes, treatment, and outcome of schizophrenia among healthcare students. Method: Undergraduate nursing and psychology students completed selected items of the Opinion on Mental Illness Questionnaire after reading a clinical vignette of undiagnosed schizophrenia. Results: Students who labelled the description as schizophrenia were more pessimistic regarding full recovery from the disorder. Those who acknowledged greater relevance to biogenetic risk factors were more convinced…
Ciència i literatura. Ja han acabat les guerres entre les dues cultures?
2014
Des que l’alquímia va començar a desafiar l’autoritat de l’Església, l’estatus del coneixement científic especialitzat i de l’alta cultura, sempre relatiu, ha estat molt qu?estionat. Durant segles, els escriptors, com a adalils de la cultura, han atacat les pretensions de la ciència ridiculitzant els seus practicants bé com a éssers malvats, obsessius i fins i tot alienats o bé com a ximples i ineptes inventors els experiments dels quals fallen irremissiblement. Discutirem exemples d’ambdós models en el seu context històric. A les acaballes del segle XX apareix un nou gènere, conegut com a «literatura de laboratori» (lab-lit). Els científics s’hi veuen retratats no segons els estereotips si…
Survival, Growth and Mycorrhization of Containerised Pinus sylvestris and Picea abies Seedlings of Different Provenances Outplanted in a Forest Clear…
2017
Abstract We studied field performance of containerised Pinus sylvestris and Picea abies seedlings of different provenances. Shoot height, needle chemical composition, root collar diameter, root mycorrhization and mycorrhizal species composition were evaluated after four growing seasons following outplanting. The results showed that in general spruce had better survival than pine. Ectomycorrhizas on spruce were dominated by Wilcoxina, Amphinema and Tylospora, while on pine — by Suillus and Thelephora species. Spruce and pine showing best growth rates were colonised by ectomycorrhizal fungus Amphinema sp. In conclusion, the results demonstrated that forest nursery practices as well as provena…
Viatge i descoberta: Superant límits
2013
Tot viatge, fins el més banal, té una dimensió de descoberta, tant del món exterior com del mateix viatger. Alguns viatgers, però, han fet i fan de la recerca mateixa l’objecte del viatge. Els objectius, els mitjans i els comportaments d’aquests viatgers han variat al llarg de la història.