Search results for "Multidisciplinary"

SU-F-T-248: FMEA Risk Analysis Implementation (AAPM TG-100) in Total Skin Electron Irradiation Technique

2016

Purpose: Total Skin Electron Irradiation (TSEI) is a radiotherapy treatment which involves irradiating the entire body surface as homogeneously as possible. It is composed of an extensive multi-step technique in which quality management requires high consumption of resources and a fluid communication between the involved staff, necessary to improve the safety of treatment. The TG-100 proposes a new perspective of quality management in radiotherapy, presenting a systematic method of risk analysis throughout the global flow of the stages through the patient. The purpose of this work has been to apply TG-100 approach to the TSEI procedure in our institution. Methods: A multidisciplinary team s…

2015

AbstractLight absorption can trigger biologically relevant protein conformational changes. The light-induced structural rearrangement at the level of a photoexcited chromophore is known to occur in the femtosecond timescale and is expected to propagate through the protein as a quake-like intramolecular motion. Here we report direct experimental evidence of such ‘proteinquake’ observed in myoglobin through femtosecond X-ray solution scattering measurements performed at the Linac Coherent Light Source X-ray free-electron laser. An ultrafast increase of myoglobin radius of gyration occurs within 1 picosecond and is followed by a delayed protein expansion. As the system approaches equilibrium i…

Novel Cancer Chemotherapy Hits by Molecular Topology: Dual Akt and Beta-Catenin Inhibitors

2015

Background and purposeColorectal and prostate cancers are two of the most common types and cause of a high rate of deaths worldwide. Therefore, any strategy to stop or at least slacken the development and progression of malignant cells is an important therapeutic choice. The aim of the present work is the identification of novel cancer chemotherapy agents. Nowadays, many different drug discovery approaches are available, but this paper focuses on Molecular Topology, which has already demonstrated its extraordinary efficacy in this field, particularly in the identification of new hit and lead compounds against cancer. This methodology uses the graph theoretical formalism to numerically chara…

Cavity-based architecture to preserve quantum coherence and entanglement

2015

Quantum technology relies on the utilization of resources, like quantum coherence and entanglement, which allow quantum information and computation processing. This achievement is however jeopardized by the detrimental effects of the environment surrounding any quantum system, so that finding strategies to protect quantum resources is essential. Non-Markovian and structured environments are useful tools to this aim. Here we show how a simple environmental architecture made of two coupled lossy cavities enables a switch between Markovian and non-Markovian regimes for the dynamics of a qubit embedded in one of the cavity. Furthermore, qubit coherence can be indefinitely preserved if the cavit…

Protecting quantum resources via frequency modulation of qubits in leaky cavities

2018

Finding strategies to preserve quantum resources in open systems is nowadays a main requirement for reliable quantum-enhanced technologies. We address this issue by considering structured cavities embedding qubits driven by a control technique known as frequency modulation. We first study a single qubit in a lossy cavity to determine optimal modulation parameters and qubit-cavity coupling regime allowing a gain of four orders of magnitude concerning coherence lifetimes. We relate this behavior to the inhibition of the qubit effective decay rate rather than to stronger memory effects (non-Markovianity) of the system. We then exploit these findings in a system of noninteracting qubits embedde…

Quantum correlations beyond entanglement in a classical-channel model of gravity

2022

A direct quantization of the Newtonian interaction between two masses is known to establish entanglement, which if detected would witness the quantum nature of the gravitational field. Gravitational interaction is yet compatible also with gravitational decoherence models relying on classical channels, hence unable to create entanglement. Here, we show in paradigmatic cases that, despite the absence of entanglement, a classical-channel model of gravity can still establish quantum correlations in the form of quantum discord between two masses. This is demonstrated for the Kafri-Taylor-Milburn (KTM) model and a recently proposed dissipative extension of this. In both cases, starting from an un…

Intermittent decoherence blockade in a chiral ring environment

2021

It has long been recognized that emission of radiation from atoms is not an intrinsic property of individual atoms themselves, but it is largely affected by the characteristics of the photonic environment and by the collective interaction among the atoms. A general belief is that preventing full decay and/or decoherence requires the existence of dark states, i.e., dressed light-atom states that do not decay despite the dissipative environment. Here, we show that, contrary to such a common wisdom, decoherence suppression can be intermittently achieved on a limited time scale, without the need for any dark state, when the atom is coupled to a chiral ring environment, leading to a highly non-e…

Resonance interaction energy between two entangled atoms in a photonic bandgap environment

2018

We consider the resonance interaction energy between two identical entangled atoms, where one is in the excited state and the other in the ground state. They interact with the quantum electromagnetic field in the vacuum state and are placed in a photonic-bandgap environment with a dispersion relation quadratic near the gap edge and linear for low frequencies, while the atomic transition frequency is assumed to be inside the photonic gap and near its lower edge. This problem is strictly related to the coherent resonant energy transfer between atoms in external environments. The analysis involves both an isotropic three-dimensional model and the one-dimensional case. The resonance interaction…

Hilbert–Schmidt speed as an efficient figure of merit for quantum estimation of phase encoded into the initial state of open n-qubit systems

2021

AbstractHilbert–Schmidt speed (HSS) is a special type of quantum statistical speed which is easily computable, since it does not require diagonalization of the system state. We find that, when both HSS and quantum Fisher information (QFI) are calculated with respect to the phase parameter encoded into the initial state of an n-qubit register, the zeros of the HSS dynamics are actually equal to those of the QFI dynamics. Moreover, the signs of the time-derivatives of both HSS and QFI exactly coincide. These findings, obtained via a thorough investigation of several paradigmatic open quantum systems, show that HSS and QFI exhibit the same qualitative time evolution. Therefore, HSS reveals its…

On-chip generation of high-dimensional entangled quantum states and their coherent control

2017

Optical quantum states based on entangled photons are essential for solving questions in fundamental physics and are at the heart of quantum information science1. Specifically, the realization of high-dimensional states (D-level quantum systems, that is, qudits, with D > 2) and their control are necessary for fundamental investigations of quantum mechanics2, for increasing the sensitivity of quantum imaging schemes3, for improving the robustness and key rate of quantum communication protocols4, for enabling a richer variety of quantum simulations5, and for achieving more efficient and error-tolerant quantum computation6. Integrated photonics has recently become a leading platform for the co…