Search results for "Multidisciplinary"
showing 10 items of 4640 documents
The hedgehog receptor patched is involved in cholesterol transport.
2011
International audience; BACKGROUND: Sonic hedgehog (Shh) signaling plays a crucial role in growth and patterning during embryonic development, and also in stem cell maintenance and tissue regeneration in adults. Aberrant Shh pathway activation is involved in the development of many tumors, and one of the most affected Shh signaling steps found in these tumors is the regulation of the signaling receptor Smoothened by the Shh receptor Patched. In the present work, we investigated Patched activity and the mechanism by which Patched inhibits Smoothened. METHODOLOGY/PRINCIPAL FINDINGS: Using the well-known Shh-responding cell line of mouse fibroblasts NIH 3T3, we first observed that enhancement …
PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation
2020
Significance The photoreceptor outer segments are primary cilia, modified for phototransduction by incorporation of stacked opsin-loaded membrane disks that are continuously regenerated. This process is disrupted in several types of inherited retinal dystrophy, but the driving force remained unclear. We show that C2orf71/PCARE (photoreceptor cilium actin regulator), associated with inherited retinal dystrophy subtype RP54, efficiently recruits the Arp2/3 complex activator WASF3 to the cilium. This activates an actin dynamics-driven expansion of the ciliary tip, resembling membrane evagination in lamellipodia formation. Colocalization of this actin dynamics module to the base of the outer se…
Long-term decrease in Asian monsoon rainfall and abrupt climate change events over the past 6,700 years
2021
Significance The variability of the Asian summer monsoon (ASM) is important for the functioning of ecological and societal systems at regional to continental scales, but the long-term evolution and interannual variability of this system is not well understood. Here, we present a stable isotope–based reconstruction of ASM variability covering 4680 BCE to 2011 CE. Superimposed on a gradual drying trend, a rapid drop in mean annual precipitation (>40%) toward persistently drier conditions occurred in ∼1675 BCE. This megadrought caused regional forest deterioration and enhanced aeolian activity affecting Chinese ecosystems. We argue that this abrupt aridification starting ∼2000 BCE triggered wa…
Evidence for a link between the Atlantic Multidecadal Oscillation and annual asthma mortality rates in the US
2019
AbstractAn association between climatic conditions and asthma mortality has been widely assumed. However, it is unclear whether climatic variations have a fingerprint on asthma dynamics over long time intervals. The aim of this study is to detect a possible correlation between climatic indices, namely the Atlantic Multidecadal Oscillation and Pacific Decadal Oscillation, and asthma mortality rates over the period from 1950 to 2015 in the contiguous US. To this aim, an analysis of non-stationary and non-linear signals was performed on time series of US annual asthma mortality rates, AMO and PDO indices to search for characteristic periodicities. Results revealed that asthma death rates evalu…
Temporal species turnover and plant community changes across different habitats in the Lake Engure Nature Park, Latvia
2014
Veģetācijas dinamikas izpētē reti ir gadījumi, kad monitoringu vienlaicīgi veic vairākās atšķirīgās ekosistēmās. Tomēr šāda veida pētījumi ļauj padziļināti izprast veģetācijas struktūras un pazīmju izmaiņu mehānismus. Šajā pētījumā aplūkotas lakstaugu stāva izmaiņas, sugu aprite un sugu skaita-laika attiecība dažādu biotopu griezumā 12 gadu periodā ILTER monitoringa stacijā Engures ezera dabas parkā. Sugu aprite laikā definēta kā atšķirība sugu sastāvā starp diviem laika periodiem. Sugu skaita-laika attiecība tika novērtēta, izmantojot slīdošo logu pieeju. Detrendētā korespondentanalīze izmantota, lai noskaidrotu ikgadējās izmaiņas sugu sastāvā. Sugu skaits un kumulatīvais skaits, kā arī da…
Embodied graffiti and street art research
2021
Graffiti and street art research (GSAR) has become more acknowledged within the academic discourse; however, it has much to gain from theorising its methodological aspects. As a multidisciplinary field, GSAR has mostly used qualitative research methods, exploring urban space through methods that range from visual recordings to ethnography, emphasising the researchers’ reflexivity. This qualitative approach has, however, paid little attention to the role of embodied practices. In this paper we discuss how embodied methodologies provide multisensory research results where the experienced moments, the participant’s and researcher’s senses, cognition and mobility in urban spaces are connected.…
Electrophysiological evidence for the effectiveness of images versus text in warnings
2023
AbstractWarning sign plays an important role in risk avoidance. Many studies have found that images are better warnings than text, while others have revealed flaws of image-only warning signs. To better understand the factors underlying the effectiveness of different types of warning signs (image only, text only, or image and text), this study adopted event-related potential technology to explore the differences at the neurocognitive level using the oddball paradigm and the Go/No-go paradigm. Together, the behavioral and electroencephalogram results showed that text-only warnings had the lowest effectiveness, but there was little difference between the image-only and image-and-text warnings…
La conquesta del lector. Reptes evolutius del periodisme científic en un ambient extrem
2014
La gran responsabilidad de los medios de comunicacion radica en que la ciudadania tiene derecho a tener una informacion cientifica de calidad. Que le sirva para tomar mejores decisiones, con espiritu critico, y para crear su propia opinion; que reactualice sus conocimientos y le haga participe de la cultura de su tiempo. En la actualidad, el entorno es cambiante y competitivo para la prensa escrita y las condiciones ambientales amenazan la supervivencia de la divulgacion. Profesionalmente, es momento de evolucionar pero tambien de conservar lo imprescindible: la esencia del buen periodismo, para diferenciarnos, con calidad y audacia, y ser asi elegidos por el publico. Debe seguir habiendo s…
Differences in Chromatic Sensitivity Estimated Using Static and Dynamic Colour Stimuli
2017
Abstract The current study reports on a novel computerised colour vision test employing static and dynamic stimuli. The aim of the study was to assess if static and dynamic stimuli result in comparable chromatic discrimination thresholds when participant’s age is taken into account. Participants (n = 20) were 21 to 77 years old, had normal colour vision and no history of any eye disease. They all participated in two sessions estimating chromatic sensitivity with static and dynamic stimuli, respectively, with six directions in colour space varying either along the red-green (RG) or yellow- blue (YB) directions. We found no significant differences in chromatic thresholds along a tritan axis o…
Genetic and Chemical Modifiers Of A CUG Toxicity Model in Drosophila
2007
Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context of a non-translatable RNA. These flies reproduced aspects of the DM1 pathology, most notably nuclear accumulation of CUG transcripts, muscle degeneration, splicing misregulation, and diminished Muscleblind function in vivo. Reduced Muscleblind activity was evident from the sensitivity of CUG-induced phenotypes to a decrease in muscleblind genetic dosage and rescue by MBNL1 expression, and furthe…