Search results for "Multidisciplinary"
showing 10 items of 4640 documents
Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons
2011
Transport of mRNAs to diverse neuronal locations via RNA granules serves an important function in regulating protein synthesis within restricted sub-cellular domains. We recently detected the Huntington's disease protein huntingtin (Htt) in dendritic RNA granules; however, the functional significance of this localization is not known. Here we report that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during dendritic transport of β-actin mRNA. Live cell imaging demonstrated that β-actin mRNA is associated with Htt, HAP1, and dynein intermediate chain in cultured neurons. Reduction in the levels of Htt, H…
In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models
2011
6 pages, 5 figures. PMID:21730182[PubMed] PMCID: PMC3141925[Available on 2012/1/19]
Palaeoclimate has a major effect on the diversity of endemic species in the hotspot of mountain biodiversity in Tajikistan.
2021
AbstractIn a period of ongoing climate changes, identifying drivers of overall and endemic species diversity is a key element in constructing new ecological patterns and determining the main goals of conservation. Such studies are especially crucial if they concern biodiversity hotspot areas. In this study, we explore patterns and drivers of plant endemism (the proportion of endemic plant species to overall plant species richness; PE) in Tajikistan. We used three groups of climatic measures featuring the contemporary and glacial climates as well as climatic changes since the Last Glacial Maximum in the Pleistocene (LGM). To explore relationships between PE and climatic groups, and the most …
Visual Acuity and Contrast Sensitivity Depending from Keratoconus Apex Position
2017
Abstract Various studies have demonstrated that patients with keratoconus have significant loss of contrast sensitivity while its value varies in different studies. None of these studies has analysed reduced contrast sensitivity depending on the position of apex of corneal conus. Visual acuity and contrast sensitivity were evaluated for patients with keratoconus using the FrACT software. Contrast sensitivity was assessed at the following frequencies: 1, 3, 5, 7, 9, 11, 13, and 15 cycles per degree (cpd). Twenty-four eyes with keratoconus were analysed. Contrast sensitivity was significantly lower for patients with the apex at the centre compared with apex on the periphery both with (p = 0.0…
A Simple Complex on the Verge of Breakdown: Isolation of the Elusive Cyanoformate Ion
2014
Cyanide Hitches a Ride Cyanide is a by-product of the biosynthesis of ethylene in plants and it has been somewhat puzzling how the ion is safely removed before it can shut down enzymatic pathways by coordination to catalytic iron centers. A proposed mechanism has implicated the cyanoformate ion—essentially, a weak adduct of cyanide and carbon dioxide—as the initial product, although its lifetime was uncertain. Murphy et al. (p. 75 ; see the Perspective by Alabugin and Mohamed ) crystallized this previously elusive adduct and found that its solution-phase stability varies inversely with the dielectric properties of the medium. The results bolster a picture in which the adduct shuttles the cy…
Single crystal X-ray structural dataset of 1,2,4-dithiazolium tetrafluoroborate
2022
Herein, we present the crystallographic dataset of 1,2,4-dithiazolium tetrafluoroborate. Single crystal X-ray structural analysis evidences that the 1,2,4-dithiazolium ring is almost planar. The 1,2,4-dithiazolium and tetrafluoroborate ions contribute in hydrogen bonding wherein the N-H·N hydrogen bonding in 1,2,4-dithiazolium dimer forms an eight-membered pseudo ring with the R22(8) Etter's graph set. The information provided in this data contributes to the understanding of structural chemistry and hydrogen bonding interactions in dithiazole derivatives.
Measurement of the cosmic ray proton spectrum from 40 GeV to 100 TeV with the DAMPE satellite
2019
DAMPE satellite has directly measured the cosmic ray proton spectrum from 40 GeV to 100 TeV and revealed a new feature at about 13.6 TeV.
Anther Culture Effectiveness in Producing Doubled Haploids of Cereals/ Putekðòu Kultûras Efektivitâte Graudaugu Dubultoto Haploîdu Izveidoðanâ
2014
Abstract Our goal was to improve the method of obtaining double haploids (DH) by anther culture from Latvian breeding material for several agriculturally important cereals in Latvia: barley, spring and winter wheat. Hybrids from Latvian breeders were initial material. It was found that copper (2.5 mg/l) added to barley anther pre-treatment media and to both barley (C3) and wheat (liquid AMC) induction media, resulted in a higher percentage of green plants-regenerants. In general, the winter wheat hybrids exhibited lower embryogenesis than spring wheat hybrids. Obtaining a large number of DH lines from barley and wheat hybrids with unknown androgenesis response can be organized in two stages…
Management of metabolic adverse events of targeted therapies and immune checkpoint inhibitors in cancer patients: an Associazione Italiana Oncologia …
2020
The growing insights in the next-generation immunotherapy and the state-of-the-art advancement in targeted-agents significantly improved clinical outcome of cancer patients by pointing towards a unexplored Achilles' heel. Novel toxicity profiles have been uncovered, representing unmet medical needs. Thus, a panel of expert provide comprehensive pharmacological and clinical evidence, to provide a patient-tailored approach to metabolic adverse events associated with novel anti-cancer treatments. Prompted by the need of a multidisciplinary cooperation, a working group of Associazione Italiana Oncologia Medica (AIOM), Associazione Medici Diabetologi (AMD) and Societa Italiana Farmacologia (SIF)…
La genètica de les migracions humanes: Seguint el rastre de les migracions a través del nostre genoma
2014
La reconstruccio de les migracions humanes es possible gracies a la informacio aportada per diverses disciplines. L’estudi de la diversitat genetica de les poblacions humanes actuals ens revela quins han estat els esdeveniments demografics i moviments migratoris passats que han deixat una empremta en el nostre genoma. El coneixement dels moviments migratoris en temps prehistorics ens permet comprovar hipotesis proposades des d’altres disciplines cientifiques. De la mateixa manera, la distribucio de la diversitat genetica en el futur dependra, en gran part, de les intenses migracions humanes actuals facilitades pels avencos tecnologics.