Search results for "Multiparametric"

On the internal multivariate quality control of analytical laboratories. A case study: the quality of drinking water

2001

Abstract Multivariate statistical process control (MSPC) tools, based on principal component analysis (PCA), partial least squares (PLS) regression and other regression models, are used in the present study for automatic detection of possible errors in the methods used for routine multiparametric analysis in order to design an internal Multivariate Analytical Quality Control (iMAQC) program. Such tools could notice possible failures in the analytical methods without resorting to any external reference since they use their own analytical results as a source for the diagnosis of the method's quality. Pseudo-univariate control charts provide an attractive alternative to traditional univariate …

Quantitative modeling of clinical, cellular, and extracellular matrix variables suggest prognostic indicators in cancer: a model in neuroblastoma

2014

BACKGROUND: Risk classification and treatment stratification for cancer patients is restricted by our incomplete picture of the complex and unknown interactions between the patient's organism and tumor tissues (transformed cells supported by tumor stroma). Moreover, all clinical factors and laboratory studies used to indicate treatment effectiveness and outcomes are by their nature a simplification of the biological system of cancer, and cannot yet incorporate all possible prognostic indicators. METHODS: A multiparametric analysis on 184 tumor cylinders was performed. To highlight the benefit of integrating digitized medical imaging into this field, we present the results of computational s…

T2 mapping of the peritumoral infiltration zone of glioblastoma and anaplastic astrocytoma.

2021

Purpose To characterise peritumoral zones in glioblastoma and anaplastic astrocytoma evaluating T2 values using T2 mapping sequences. Materials and methods In this study, 41 patients with histopathologically confirmed World Health Organization high grade gliomas and preoperative magnetic resonance imaging examinations were retrospectively identified and enrolled. High grade gliomas were differentiated: (a) by grade, glioblastoma versus anaplastic astrocytoma; and (b) by isocitrate dehydrogenase mutational state, mutated versus wildtype. T2 map relaxation times were assessed from the tumour centre to peritumoral zones by means of a region of interest and calculated pixelwise by using a fit m…

DIAGNOSTIC ACCURACY OF IXIP INDEX AND PROSTATE MRI IN THE DIAGNOSIS OF PROSTATE CANCER: PRELIMINARY RESULTS ON A COMBINED APPROACH

2021

The purpose of this study was to assess whether Immune CompleX Predictive Index (iXip) improves diagnostic accuracy of multiparametric prostate MRI (mpMRI) for clinically significant prostate cancer. This study included 72 patients (mean age: 68±8 years) with suspicion of prostate cancer and available iXip score. mpMRI images were evaluated by two radiologists according to the PI-RADS v2.1. Reference standard was based on fusion biopsy and standard transperineal 12-point biopsy. Diagnostic accuracy of iXip, mpMRI and their combination were calculated. Optimal cutoff of iXip with sensitivity and specificity was identified using the Youden index. Patients with clinically significant prostate …

Evaluation of the Effects of the Enriched-Organic Diets Composition on European Sea Bass Welfare through a Multi-Parametric Approach

2020

Three groups of European sea bass (Dicentrarchus labrax) were fed for seven months, with either a conventional diet or two different organic diets, which contain organic vegetables and a natural antioxidant compound. The two organic diets differed themselves in terms of raw proteins, fish oil, and lipid contents. Sea bass welfare condition was assessed in relation to these three diets, using 16 different indicators. These were: swimming activity (recovery test, muscle activity), haematological and serological stress indicators (haematocrit, haemoglobin, red-blood-cell count, cortisol, glucose, lactate), aspecific immunity parameter (lysozyme), indicators of exposure to organic contaminants …

Multiparametric-MRI evaluation of cervical nodes in patients with head and neck squamous cell carcinoma (HNSCC)

Un approccio multi-scala per la valutazione della suscettibilità da frana a livello regionale: il progetto SUFRA (SUscettibilità da FRAna) in Sicilia

2012

L’attuale versione del PAI (Piano Stralcio per l'Assetto Idrogeologico) disponibile per il territorio siciliano è fortemente dipendente dallo scenario di dissesti passati censiti e catalogati, sulla base dei quali, utilizzando un sistema di matrici di valutazione, è possibile ricavare le condizioni di rischio geomorfologico associato. Questo stadio costituisce un primo grande avanzamento delle conoscenze a partire dal quale è ora necessario procedere alla valutazione della suscettibilità da frana e all’adozione dunque di uno strumento di analisi territoriale con carattere previsionale. La realizzazione di una cartografia della suscettibilità da frana a scala regionale pone d’altra parte una…

Multi-parametric GIS analysis to assess gully erosion susceptibility: a test in southern Sicily, Italy

2011

: A GIS-analysis was carried out in a test basin of southern Sicily, the Magazzolo River basin, in order to assess susceptibility conditions to gully erosion phenomena. The linear density of ephemeral and permanent gullies computed within each class of nine environmental variables was used to generate a gully erosion susceptibility map for the area. A validation procedure carried out in order to test the reliability of the adopted method highlighted a clear correlation between the occurrence of gullies and the computed susceptibility levels

VESICAL IMAGING-REPORTING AND DATA SYSTEM – A NEW APPROACH TO BLADDER CANCER STAGING

2022

The aim: To present the assumptions and to show the usefulness of Vesical Imaging-Reporting and Data System (VI-RADS) based on multiparametric magnetic resonance imaging (mpMRI) in the diagnostic pathway management of patients with a bladder cancer. Materials and methods: The review is based on available literature from last 10 years from PubMed database and the Przegląd Urologiczny journal focusing on articles on VI-RADS. Overall, 18 articles were included. Presented magnetic resonance images come from the examinations of the patients who were diagnosed with bladder cancer from 2019 to 2021 at Department of Diagnostic Imaging in University Clinical Hospital in Opole, Poland. Conclusions: T…

Monitoring of mixed culture fermentations

2022

Current and future constraints linked to climate change and evolution of wine consumer demand are prompting the winemaking industry to consider adopting new practices to address the technical challenges resulting from this context. These challenges include the need to maintain a constant alcohol level despite increased sugar contents in the must, and to seek a wider diversity of aromatic profiles, while maintaining acceptable reproducibility.Fermentations with addition of non-Saccharomyces yeasts to the Saccharomyces cerevisiae species traditionally used to conduct alcoholic fermentation seem to be an interesting alternative to achieve these objectives. However, the numerous interactions be…