Search results for "Multiple"
showing 10 items of 2678 documents
Differential changes in purine nucleotides after Doxorubicin treatment of human cancer cells in vitro
2002
The present investigation was performed to elucidate the role of purine nucleotides as potential indicators of chemosensitivity of malignant tumors. Drug-sensitive (s) and -resistant (r) tumor cell lines grown as monolayers (s: T47D, MCF-7 wild-type; r: NCI/ADR-RES, MCF-7/MDR) or as multicellular spheroids (T47D; NCI/ADR-RES) were exposed to 0.1, 1.0, and 10.0 microM Doxorubicin for up to 24 h. Purine nucleotides were assayed using HPLC and with some selected spheroids using imaging bioluminescence. The data show that in the time frame of the experiments reproducible and statistically significant changes in the nucleotides only occur at the highest drug concentration investigated. Under the…
Combining super-orthogonal space-frequency trellis coding, constellation shaping by shell mapping, and OFDM for high data rate broadband mobile commu…
2014
In this paper, we seamlessly combine three transmission techniques to design an improved performance broadband mobile communication system with two transmit antennas. In so doing, we took inspiration from the V.34 data modem toolbox designed for public switched telephone network. We modified the constellation shaping by shell mapping algorithm to apply it only to the orthogonal frequency division multiplexing (OFDM) frame sent by the first antenna, in such a way that the peak-to-average power ratio (PAPR) is also reduced for the second antenna. We use a 24-point quadrature amplitude modulation (QAM) signal constellation on each subcarrier, while the reference system employs 16 QAM for the s…
Reducing the peak and average power for OFDM systems using QAM by constellation shaping
2009
In this paper, we present a shell mapping scheme to reduce the peak and average power of orthogonal frequency division multiplexing (OFDM) signals using quadrature amplitude modulation (QAM) by constellation shaping. Our approach can be considered as an extension of the shell mapping technique introduced originally in the V.34 recommendation of ITU-T. The shell mapping method uses multiple cost functions, each having the OFDM block length N as a parameter. The cost functions are presented in closed form for any N. The main advantage of the proposed scheme is that the peak and average power can be reduced without sacrificing the data rate, and no side information is needed at the receive sid…
TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23)
2015
Joubert syndrome (JBTS) is a severe recessive neurodevelopmental ciliopathy which can affect several organ systems. Mutations in known JBTS genes account for approximately half of the cases. By homozygosity mapping and whole-exome sequencing, we identified a novel locus, JBTS23, with a homozygous splice site mutation in KIAA0586 (alias TALPID3), a known lethal ciliopathy locus in model organisms. Truncating KIAA0586 mutations were identified in two additional patients with JBTS. One mutation, c.428delG (p.Arg143Lysfs*4), is unexpectedly common in the general population and may be a major contributor to JBTS. We demonstrate KIAA0586 protein localization at the basal body in human and mouse p…
Potential Biomarkers Associated with Multiple Sclerosis Pathology
2021
Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS) that involves an intricate and aberrant interaction of immune cells leading to inflammation, demyelination, and neurodegeneration. Due to the heterogeneity of clinical subtypes, their diagnosis becomes challenging and the best treatment cannot be easily provided to patients. Biomarkers have been used to simplify the diagnosis and prognosis of MS, as well as to evaluate the results of clinical treatments. In recent years, research on biomarkers has advanced rapidly due to their ability to be easily and promptly measured, their specificity, and their reproducibility. Biomarkers are classified into several categor…
Stochastic response of MDOF wind-excited structures by means of Volterra series approach
1998
Abstract The role played by the quadratic term of the forcing function in the response statistics of multi-degree-of-freedom (MDOF) wind-excited linear-elastic structures is investigated. This is accomplished by modeling the structural response as a Volterra series up to the second order and neglecting the wind-structure interaction. In order to reduce the computational effort due to the calculation of a large number of multiple integrals, required by the used approach, a recent model of the wind stochastic field is adopted.
Toward a Quality Guide to Facilitate the Transference of Analytical Methods from Research to Testing Laboratories: A Case Study
2009
Abstract At present, there is no single viewpoint that defines QA strategies in analytical chemistry. On the other hand, there are no unique protocols defining a set of analytical tasks and decision criteria to be performed during the method development phase (e.g., by a single research laboratory) in order to facilitate the transference to the testing laboratories intending to adapt, validate, and routinely use this method. This study proposes general criteria, a priori valid for any developed method, recommended as a provisional quality guide containing the minimum internal tasks necessary to publish new analytical method results. As an application, the selection of some basic internal qu…
Lipid-containing semipermeable membrane devices (SPMDs) as concentrators of toxic chemicals in the lower Fraser River, Vancouver, British Columbia.
1998
Abstract Semipermeable membrane devices (SPMDs) were deployed in the water column and in the sediments of the Lower Fraser River (B.C., Canada) to compare the levels and the congener profiles of polychlorinated dibenzo- p -dioxins (PCDDs), dibenzofurans (PCDFs) and non- ortho -chlorinated biphenyls (N-o,o′-PCBs) against those sampled by an Infiltrex resin column water sampler. Also the relationship between what was present in the ecosystem as sampled by SPMDs and what was accumulated in the tissue of resident benthic-feeding fish was explored. Only the lipid portion of the SPMDs was prepared for analysis, due to some technical difficulties in cleaning the polyethene tubing. The calculated w…
Identification of patterns og change on mongitudinal data, illustrated by two exemples : study of hospital pathways in the management of cancer. Cons…
2014
Context In healthcare domain, data mining for knowledge discovery represent a growing issue. Questions about the organisation of healthcare system and the study of the relation between treatment and quality of life (QoL) perceived could be addressed that way. The evolution of technologies provides us with efficient data mining tools and statistical packages containing advanced methods available for non-experts. We illustrate this approach through two issues: 1 / What organisation of healthcare system for cancer diseases management? 2 / Exploring in patients suffering from metastatic cancer, the relationship between health-related QoL perceived and treatment received as part of a clinical tr…
Rehabilitation for Multiple Sclerosis in Adults (I); Impairment and Impact on Functioning and Quality of Life: An Overview
2010
Multiple sclerosis (MS) is a chronic, central nervous system, disabling disease. International Classification of Functioning and relevant generic and specific outcome measures are reported. Problems perceived by people with MS (PwMS) affect mobility, sight, continence, feeding, or cognitive impairment, depending on whether acute, chronic, or long-term disability was involved. The most common body function and structure impairments leading to disability and reported by health care professionals are fatigue, weakness, decreased fitness, sensory disorders, pain, upper motor neuron syndromes, ataxia and tremor, balance and postural control problems, gait pattern disorders, visual problems, and …