Search results for "Multiple"
showing 10 items of 2678 documents
A Comparative Study of Nonlinear Machine Learning for the "In Silico" Depiction of Tyrosinase Inhibitory Activity from Molecular Structure.
2011
In the preset report, for the first time, support vector machine (SVM), artificial neural network (ANN), Baye- sian networks (BNs), k-nearest neighbor (k-NN) are applied and compared on two "in-house" datasets to describe the tyrosinase inhibitory activity from the molecular structure. The data set Data I is used for the identification of tyrosi- nase inhibitors (TIs) including 701 active and 728 inactive compounds. Data II consists of active chemicals for potency estimation of TIs. The 2D TOMOCOMD-CARDD atom-based quadratic indices are used as molecular descriptors. The de- rived models show rather encouraging results with the areas under the Receiver Operating Characteristic (AURC) curve …
An approach to identify new antihypertensive agents using Thermolysin as model: In silico study based on QSARINS and docking
2019
Thermolysin is a bacterial proteolytic enzyme, considered by many authors as a pharmacological and biological model of other mammalian enzymes, with similar structural characteristics, such as angiotensin converting enzyme and neutral endopeptidase. Inhibitors of these enzymes are considered therapeutic targets for common diseases, such as hypertension and heart failure. In this report, a mathematical model of Multiple Linear Regression, for ordinary least squares, and genetic algorithm, for selection of variables, are developed and implemented in QSARINS software, with appropriate parameters for its fitting. The model is extensively validated according to OECD standards, so that its robust…
Temporal multiplexing with adaptive optics for simultaneous vision.
2016
We present and test a methodology for generating simultaneous vision with a deformable mirror that changed shape at 50 Hz between two vergences: 0 D (far vision) and −2.5 D (near vision). Different bifocal designs, including toric and combinations of spherical aberration, were simulated and assessed objectively. We found that typical corneal aberrations of a 60-year-old subject changes the shape of objective through-focus curves of a perfect bifocal lens. This methodology can be used to investigate subjective visual performance for different multifocal contact or intraocular lens designs.
Task-based visual analytics for interactive multiobjective optimization
2020
We study how visual interaction techniques considered in visual analytics can be utilized when implementing interactive multiobjective optimization methods, where a decision maker iteratively participates in the solution process. We want to benefit from previous research and avoid re-inventing ideas. Our aim is to widen awareness and increase the applicability of interactive methods for solving real-world problems. As a concrete approach, we introduce seven high-level tasks that are relevant for interactive methods. These high-level tasks are based on low-level tasks proposed in the visual analytics literature. In addition, we give an example on how the high-level tasks can be implemented a…
Foxp3 and gata3 polymorphisms, vitamin d3 and multiple sclerosis
2021
Background: Regulatory T cells (Tregs) alterations have been implicated in the pathogenesis of Multiple Sclerosis (MS). Recently, a crucial role of the X-Linked Forkhead Box P3 (FoxP3) for the development and the stability of Tregs has emerged, and FOXP3 gene polymorphisms have been associated with the susceptibility to autoimmune diseases. The expression of Foxp3 in Tregs is regulated by the transcription factor GATA binding-protein 3 (GATA3) and vitamin D3. The aim of this retrospective case-control study was to investigate the potential association between FOXP3 and GATA3 genetic variants, Vitamin D3, and MS risk. Methods: We analyzed two polymorphisms in the FOXP3 gene (rs3761547 and rs…
The Contributions of Language Skills and Comprehension Monitoring to Chinese Reading Comprehension: A Longitudinal Investigation
2021
This study examined how vocabulary, syntactic knowledge, and orthographic knowledge are related to comprehension monitoring and whether comprehension monitoring mediates the relations between these language skills and reading comprehension. Eighty-nine Chinese children were assessed on their vocabulary, syntactic knowledge, orthographic knowledge, and comprehension monitoring in Grade 1. Their reading comprehension skills were assessed in Grade 1 and Grade 3. Results showed that in Grade 1, comprehension monitoring mediated the relations between vocabulary and syntactic knowledge and reading comprehension. For Grade 3 reading comprehension, syntactic knowledge in Grade 1 was the only signif…
VoIP end-to-end performance in HSPA with packet age aided HSDPA scheduling
2008
In this paper, we present an enhanced VoIP scheduling for the high speed downlink packet access (HSDPA) in UMTS, which takes the age of the VoIP packet into account. The downlink capacity can be significantly improved by this way, especially for shorter uplink transmission delay. In order to quantify the achievable performance improvement, we present results obtained from extensive system-level uplink and downlink simulations. Inter alia, it is shown that using the proposed scheme can lead to an increase in the downlink cell capacity of up to 16%. By applying the proposed method, the downlink performance can be improved considerably while the uplink performance remains the same, which ensur…
On Serving Cell Change Reliability in HSDPA Network
2009
In Wideband Code Division Multiple Access (WCDMA) networks the Signaling Radio Bearer (SRB) is transmitted downlink to inform the user i.a. when it needs to make a handover. When transmitting e.g. Voice over IP (VoIP) on High Speed Downlink Packet Access (HSDPA) SRB is mapped on HSDPA user data channel, High-Speed Downlink Shared Channel (HS-DSCH) in order to maximize voice capacity. The lack of support for soft handover (SHO) of HS-DSCH may compromise the reception of SRB and thus also a possible incoming serving HSDPA cell change command especially at the cell borders. This can lead to serious VoIP service degradation due to prolonged camping on a poor cell and in the worst case even to c…
Beyond GDP: an analysis of the socio-economic diversity of European regions
2019
International audience; This paper aims to analyze the socioeconomic diversity of the European Union (EU-28) regions from a dynamic perspective. For that purpose, we combine a series of exploratory space-time analysis approaches to multiple Factor Analysis (MFA) applied to a large range of indicators collected at the NUTS-2 level for the period 2000–2015 for the EU-28. First, we find that the first factor of MFA, interpreted as economic development (ECO-DEV), is spatially clustered and that a moderate convergence process is at work between European regions from 2000 to 2015. Second, when comparing these results with those obtained for Gross Domestic Product (GDP) per capita, we show that th…
Agent assisted interactive algorithm for computationally demanding multiobjective optimization problems
2015
Abstract We generalize the applicability of interactive methods for solving computationally demanding, that is, time-consuming, multiobjective optimization problems. For this purpose we propose a new agent assisted interactive algorithm. It employs a computationally inexpensive surrogate problem and four different agents that intelligently update the surrogate based on the preferences specified by a decision maker. In this way, we decrease the waiting times imposed on the decision maker during the interactive solution process and at the same time decrease the amount of preference information expected from the decision maker. The agent assisted algorithm is not specific to any interactive me…