Search results for "Multiple"

Mononeuropathy multiplex as a result of treatment with interferon-α and ribavirin in a patient with hepatitis C

2008

Longitudinal Immunogenomic Profiling of Tumor and Immune Cells for Minimally-Invasive Monitoring of Smoldering Multiple Myeloma (SMM): The Immunocell…

2020

Background: Although great strides were made in the management of MM, our best chances to eradicate this malignancy may lie in preventing its progression.Most current models to predict risk of transformation in SMM are commonly established at diagnosis and not reevaluated over time, because some parameters such as tumor burden or genetic abnormalities require invasive bone marrow (BM) aspirates. It could be hypothesized that periodic monitoring of tumor biomarkers is needed to improve risk-stratification of SMM patients, and so would be new minimally-invasive methods that can replace those performed in BM samples. Such methods should also monitor immune profiles, to identify patients with s…

Patientenverfügung: Wahrnehmung und Wirklichkeit

2008

BACKGROUND Knowledge and values prevalent with regard to advanced directive in the general German population have so far not been adequately taken into account as a topic of regulatory initiatives. This leads to unnecessary uncertainty about actual decision-making concerning therapeutic measures. METHODS 95 randomly chosen persons were included in a differentiated, online-supported survey consisting of multiple-choice questions as well as open interview questions, both question types addressing knowledge and values prevalent in our populations concerning advanced health care directives. Multiple choice questions were statistically correlated with open answers addressing the same content and…

Impact of DLI after In Vivo T-Cell-Depletion: Prophylactic CD8 Depleted or Preemptive CD3pos DLI?

2016

Abstract Introduction: The combination of reduced-intensity conditioning (RIC) with in vivo T-cell depletion by alemtuzumab prior to hematopoietic stem cell transplantation (HSCT) has demonstrated efficient engraftment and reduced graft-versus-host disease (GVHD). However, this regimen is associated with slow lymphocyte recovery leading to a delayed anti-infectious and anti-malignant immunity. DLI can be used to improve immune reconstitution. Here we investigate on the impact of different DLI: prophylactic CD8-depleted DLI vs preemptive non-depleted DLI. Methods: 256 patients with different hematologic malignancies were planned for treatment with DLI after allogeneic HSCT following reduced …

B cells assume the command

2015

A proinflammatory B cell cytokine activates autoimmunity, and B cell depletion treats multiple sclerosis (Li et al., this issue).

Anti-resorptive treatment in osteoporosis and their deleterious effects on maxillary bone metabolism in clinical dentistry

2017

Bisphosphonates (BPs) and other antiresorptive agents such as denosumab are widely prescribed for the treatment of osteoporosis and are also used in patients with multiple myeloma and metastatic breast or prostate cancer for avoiding bone reabsorption and fractures that result in increased morbidity–mortality among such individuals. Osteonecrosis of the jaws is an important complication of exposure to BPs or other antiresorptive agents, and although its prevalence is low, it can pose management problems. The definition, diagnosis, and classification of osteonecrosis have evolved since Marx reported the first cases in 2003. The present chapter offers a review and update on the existing diagn…

Mortality in multiple sclerosis: a review.

2008

This work was undertaken to evaluate studies on mortality caused by multiple sclerosis (MS), to evaluate if useful inferences can be drawn from survival studies that can be applied to clinical practice. A literature search was carried out to find epidemiological studies on MS prognosis, survival, mortality and causes of death relevant to our aim. The World Health Organization (WHO) reports on worldwide cause-specific mortality were also considered. Studies were evaluated according to the duration of the follow-up study, the year of publication and the methodology used. We evaluated MS survival from a methodological point of view and considered if time trends could be drawn from study result…

Spectrally selective holographic optical elements based on a thick polymer medium with diffusional amplification

2000

A thick rigid polymer recording medium with self-amplification of holograms owing to diffusion of phenanthrenequinone molecules was used to find efficient holographic optical elements with high-spectral-selectivity interference filters and multiple demultiplexers. Several examples of practical applications are briefly described in this paper, showing the benefits of such optical elements for the fields of astronomy, spectroscopy and communication technologies.

A very simple one-pot electrosynthesis of nitrones starting from nitro and aldehyde components

2018

The cathodic treatment of nitroarenes in the presence of aldehydes yields directly and selectively nitrones. Electrolysis can be conducted on a very simple undivided beaker-type cell under constant current conditions. The conversion tolerates multiple bonds, a variety of functional groups and heterocyclic moieties. Competing reductive conversions such as pinacolization are not observed. The green aspects of this electro-conversion are avoidance of metals, an environmentally benign solvent mixture, and stable as well as sustainable carbon electrodes.

Rapid evaluation of oxidised fatty acid concentration in virgin olive oil using Fourier-transform infrared spectroscopy and multiple linear regression

2011

Abstract Fourier-transform infrared spectroscopy (FTIR), followed by multivariate treatment of spectral data, was used to evaluate the oxidised fatty acid (OFA) concentration in virgin olive oil samples characterised by different oxidative status. The entire FTIR spectra (4000–700 cm−1) of oils were divided in 25 wavelength regions. The normalised absorbances of the peak areas within these regions were used as predictors. In order to predict the OFA concentration, multiple linear regression (MLR) models were performed. After a cube root transformation of data, an MLR model constructed using eight predictors was able to predict OFA concentration with an average error of 17%. The main wavelen…