Search results for "Multiple"
showing 10 items of 2678 documents
Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules.
1998
AbstractChromosome 11p15.5 harbors a gene or genes involved in Beckwith-Wiedemann syndrome that confer(s) susceptibility to Wilms' tumor, rhabdomyosarcoma, and hepatoblastoma. We have previously identified a transcript at 11p15.5 which encodes a putative membrane transport protein, designated organic cation transporter-like 2 (ORCTL2), that shares homology with tetracycline resistance proteins and bacterial multidrug resistance proteins. In this report, we have investigated the transport properties of ORCTL2 and show that this protein can confer resistance to chloroquine and quinidine when overexpressed in bacteria. Immunohistochemistry analyses performed with anti-ORCTL2 polyc.onal antibod…
A scoping review on interventions to promote physical activity among adults with disabilities
2016
People with disabilities are at increased risk for obesity as well as other secondary conditions that lead to further decline in health and functional status. Despite there being strong evidence that physical activity (PA) can help to reduce the incidence and severity of preventable conditions, approximately half of all adults with disabilities get no regular physical activity. In addition, there is limited knowledge on the PA promotion interventions effectiveness among individuals with disabilities. Recently the Behaviour Change Techniques Taxonomy version 1 (BCT Taxonomy v1) became available as a method for reporting, replicating, and synthesizing research evidence, yet it is lacking in s…
An approach for influence estimatation in complex networks : application to the social network Twitter
2019
Influence in complex networks and in particular Twitter has become recently a hot research topic. Detecting most influential users leads to reach a large-scale information diffusion area at low cost, something very useful in marketing or political campaigns. In this thesis, we propose a new approach that considers the several relations between users in order to assess influence in complex networks such as Twitter. We model Twitter as a multiplex heterogeneous network where users, tweets and objects are represented by nodes, and links model the different relations between them (e.g., retweets, mentions, and replies).The multiplex PageRank is applied to data from two datasets in the political…
BIO-Bragg gratings: structured molecular networks for on-fiber bioanalysis
2021
The research on photonic biosensors is a scientific hot topic at the moment, with a significant potential impact on industry and medicine. Label-free, miniaturized, inexpensive and low-loss biosensors are developed based on optical fiber technology. Our approach is based on a Bio-Bragg-Grating (BBG) patterned on the surface of a microfiber. We present the design, fabrication and proof of concept of our device, as well as its multiplexing and tunability perspectives [1] .
Therapeutic implications of targeting antioxidants to mitochondria
2021
Abstract Redox and oxidative balance are mainly regulated by mitochondria, which control the life and death of cells and organisms, and are therefore implicated in multiple pathologies. Mitochondria can be considered key organelles to be used in different therapeutically approaches, and mitochondria-targeted antioxidants have already shown great potential in the treatment of various human diseases. In fact, major progress has been achieved in the development of different molecules targeted to mitochondria. In this chapter, we will discuss the various strategies that have been employed, such as molecules conjugated with lipophilic cations (e.g., triphenylphosphonium) and peptide-based compou…
Biogenic amines in fermented foods
2010
Food-fermenting lactic acid bacteria (LAB) are generally considered to be non-toxic and non-pathogenic. Some species of LAB, however, can produce biogenic amines (BAs). BAs are organic, basic, nitrogenous compounds, mainly formed through decarboxylation of amino acids. BAs are present in a wide range of foods, including dairy products, and can occasionally accumulate in high concentrations. The consumption of food containing large amounts of these amines can have toxicological consequences. Although there is no specific legislation regarding BA content in many fermented products, it is generally assumed that they should not be allowed to accumulate. The ability of microorganisms to decarbox…
Array CGH defined interstitial deletion on chromosome 14: a new case
2009
Interstitial deletions of the long arm of chromosome 14 are relatively rare. We report a 8.5-year-old girl with dysmorphic facial features and mental retardation associated with a de novo interstitial deletion of chromosome 14. The comparison between our patient and all published patients is reviewed. The genetic investigations have allowed us to define the critical chromosomal region and to start an accurate follow-up.
Label-free piezoelectric biosensor for prognosis and diagnosis of Systemic Lupus Erythematosus
2017
[EN] An autoantigen piezoelectric sensor to quantify specific circulating autoantibodies in human serum is developed. The sensor consisted on a quartz crystal microbalance with dissipation monitoring (QCM-D) where TRIM21 and TROVE2 autoantigens were covalently immobilized, allowing the selective determination of autoantibodies for diagnosis and prognosis of Systemic Lupus Erythematosus (SLE). The sensitivity of the biosensor, measured as IC50 value, was 1.51 U/mL and 0.32 U/mL, for anti-TRIM21 and anti-TROVE2 circulating autoantibodies, respectively. The sensor is also able to establish a structural interaction fingerprint pattern or profile of circulating autoantibodies, what allows scorin…
Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study
2020
Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, and causal relationships between pain and biopsychosocial factors in MS are largely unknown. Longitudinal studies might help to clarify the prevalence and determinants of pain in MS. To this end, we analyzed data from 410 patients with newly diagnosed clinically isolated syndrome or relapsing-remitting MS participating in the prospective multicenter German National MS Cohort Study (NationMS) at baseline and after 4 years. Pain was assessed by self-report using the PainDETECT Questionnaire. Neuropsychiatri…
Channel Estimation and Interference Cancellation for MIMO-OFDM Systems
2007
This paper proposes a new channel estimation method and a new interference cancellation scheme for multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) systems in the presence of intersymbol interference (IS1). The proposed channel estimation method uses special training sequences (TSs) to have a desirable crest-factor of the transmitted training signal, and to prevent the influence of ISI on the channel estimation performance. By using the recommended training sequences, the ill-conditioned problem of the least square (LS) filter integrated in the proposed channel estimator can be avoided. The proposed interference cancellation scheme uses the estimated cha…