Search results for "Multiplex"
showing 10 items of 337 documents
Multiplex ligation-dependent probe amplification detection of an unknown large deletion of the CREB-binding protein gene in a patient with Rubinstein…
2013
Rubinstein-Taybi syndrome is a rare autosomal dominant congenital disorder characterized by postnatal growth retardation, psychomotor developmental delay, skeletal anomalies, peculiar facial morphology, and tumorigenesis. Mutations in the gene encoding the cAMP response element-binding protein (CREB, also known as CREBBP or CBP) on chromosome 16p13.3 have been identified. In addition, some patients with low intelligence quotients and autistic features bear large deletions. Based on these observations, we used multiplex ligation-dependent probe amplification to search for large deletions affecting the CREBBP gene in a Rubinstein-Taybi syndrome patient. We identified a novel heterozygote dele…
CORAL Server and CORAL Server Proxy: Scalable Access to Relational Databases from CORAL Applications
2011
The CORAL software is widely used at CERN for accessing the data stored by the LHC experiments using relational database technologies. CORAL provides a C++ abstraction layer that supports data persistency for several backends and deployment models, including local access to SQLite files, direct client access to Oracle and MySQL servers, and read-only access to Oracle through the FroNTier web server and cache. Two new components have recently been added to CORAL to implement a model involving a middle tier "CORAL server" deployed close to the database and a tree of "CORAL server proxy" instances, with data caching and multiplexing functionalities, deployed close to the client. The new compon…
Single-exposure super-resolved interferometric microscopy by RGB multiplexing in lensless configuration
2016
Abstract Single-Exposure Super-Resolved Interferometric Microscopy (SESRIM) reports on a way to achieve one-dimensional (1-D) superresolved imaging in digital holographic microscopy (DHM) by a single illumination shot and digital recording. SESRIM provides color-coded angular multiplexing of the accessible sample׳s range of spatial frequencies and it allows their recording in a single CCD (color or monochrome) snapshot by adding 3 RGB coherent reference beams at the output plane. In this manuscript, we extend the applicability of SESRIM to the field of digital in-line holographic microscopy (DIHM), that is, working without lenses. As consequence of the in-line configuration, an additional r…
Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis
2020
Glioblastoma multiforme (GB) is one of the most aggressive tumors. Despite continuous efforts to improve its clinical management, there is still no strategy to avoid a rapid and fatal outcome. EGFR amplification is the most characteristic alteration of these tumors. Although effective therapy against it has not yet been found in GB, it may be central to classifying patients. We investigated somatic-copy number alterations (SCNA) by multiplex ligation-dependent probe amplification in a series of 137 GB, together with the detection of EGFRvIII and FISH analysis for EGFR amplification. Publicly available data from 604 patients were used as a validation cohort. We found statistical associations…
Analysis of duplexing modes in the IEEE 802.16 wireless system
2010
The IEEE 802.16 standard defines two main duplexing modes: Time Division Duplexing (TDD) and Frequency Division Duplexing (FDD). The FDD can be divided further into Full-FDD (F-FDD) and Half-FDD (H-FDD). F-FDD requires full duplexing support from subscriber stations and works with two frequency bands. TDD operates a single frequency band, but it does not need full-duplexing support. H-FDD is a combination of these: it works with two frequency bands and does not require full-duplexing support. The cost of this is a more complicated scheduling and added overhead. Still, H-FDD might be the only possible duplexing mode in some occasions. In this paper, these duplexing modes are compared and the…
Super resolving optical system based on spectral dilation
2004
Time multiplexing is a common approach for achieving super resolution. The basic method involves moving two grating one is in front of the object and the other one in front of the camera. In this paper, we present a novel approach for obtaining super resolution not by shifting a grating, but by using its various dilations for obtaining the required encoding and decoding of information.
Multiplexing of encrypted data using fractal masks
2012
In this Letter, we present to the best of our knowledge a new all-optical technique for multiple-image encryption and multiplexing, based on fractal encrypting masks. The optical architecture is a joint transform correlator. The multiplexed encrypted data are stored in a photorefractive crystal. The fractal parameters of the key can be easily tuned to lead to a multiplexing operation without cross talk effects. Experimental results that support the potential of the method are presented.
A Protein-Interaction Array Inside a Living Cell
2013
Cell phenotype is determined by protein network states that are maintained by the dynamics of multiple protein interactions.1 Fluorescence microscopy approaches that measure protein interactions in individual cells, such as by Forster resonant energy transfer (FRET), are limited by the spectral separation of fluorophores and thus are most suitable to analyze a single protein interaction in a given cell. However, analysis of correlations between multiple protein interactions is required to uncover the interdependence of protein reactions in dynamic signal networks. Available protein-array technologies enable the parallel analysis of interacting proteins from cell extracts, however, they can …
Joint Distribution of Polarization-Multiplexed UWB and WiMAX Radio in PON
2009
[EN] In this paper, the feasibility of the joint distribution of ultra-wideband (UWB) and WIMAX wireless using polarization multiplexing as a coexistence technique is proposed and experimentally demonstrated within the framework of passive optical networks (PON). Four single- and orthogonal-polarization multiplexing schemes are studied targeting to reduce the mutual interference when UWB and WiMAX are distributed jointly through standard single-mode fiber (SSMF) without transmission impairments compensation techniques and amplification. Experimental results indicate successful transmission up to 25 km, in SSMF exceeding the range in typical PON deployments. The radio link penalty introduced…
Secondary users selection and sparse narrow-band interference mitigation in cognitive radio networks
2018
Spectrum scarcity is a critical problem that may reduce the effectiveness of wireless technologies and services. To address this problem, different spectrum management techniques have been proposed in the literature such as overlay cognitive radio (CR) where the unlicensed users can share the same spectrum with the licensed users. The main challenges in overlay CR networks are the identification and detection of the Primary User (PU) signals in a multi-source narrow-band interference (NBI) scenario. Therefore, in this paper, we investigate the performance of an orthogonal frequency division multiplexing (OFDM) overlay CR network with Secondary Users (SUs) and subcarriers selection schemes. …