Search results for "Multiplex"
showing 10 items of 337 documents
Biogenic amines in fermented foods
2010
Food-fermenting lactic acid bacteria (LAB) are generally considered to be non-toxic and non-pathogenic. Some species of LAB, however, can produce biogenic amines (BAs). BAs are organic, basic, nitrogenous compounds, mainly formed through decarboxylation of amino acids. BAs are present in a wide range of foods, including dairy products, and can occasionally accumulate in high concentrations. The consumption of food containing large amounts of these amines can have toxicological consequences. Although there is no specific legislation regarding BA content in many fermented products, it is generally assumed that they should not be allowed to accumulate. The ability of microorganisms to decarbox…
Label-free piezoelectric biosensor for prognosis and diagnosis of Systemic Lupus Erythematosus
2017
[EN] An autoantigen piezoelectric sensor to quantify specific circulating autoantibodies in human serum is developed. The sensor consisted on a quartz crystal microbalance with dissipation monitoring (QCM-D) where TRIM21 and TROVE2 autoantigens were covalently immobilized, allowing the selective determination of autoantibodies for diagnosis and prognosis of Systemic Lupus Erythematosus (SLE). The sensitivity of the biosensor, measured as IC50 value, was 1.51 U/mL and 0.32 U/mL, for anti-TRIM21 and anti-TROVE2 circulating autoantibodies, respectively. The sensor is also able to establish a structural interaction fingerprint pattern or profile of circulating autoantibodies, what allows scorin…
Channel Estimation and Interference Cancellation for MIMO-OFDM Systems
2007
This paper proposes a new channel estimation method and a new interference cancellation scheme for multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) systems in the presence of intersymbol interference (IS1). The proposed channel estimation method uses special training sequences (TSs) to have a desirable crest-factor of the transmitted training signal, and to prevent the influence of ISI on the channel estimation performance. By using the recommended training sequences, the ill-conditioned problem of the least square (LS) filter integrated in the proposed channel estimator can be avoided. The proposed interference cancellation scheme uses the estimated cha…
Performance Analysis of STBC-OFDM Systems in Temporally or Spatially Correlated Fading Channels
2010
This paper analyzes the performance of space-time block coded orthogonal frequency division multiplexing (OFDM) systems. In our analysis, we abandon the usually made assumption of quasi-static channel conditions. Instead of this, we consider the more general and realistic case that the channel envelope changes during two consecutive transmission time slots. In addition, we take the spatial correlation between sub-channels into account. We first present a general formal expression for the bit error probability (BEP), from which we find analytical solutions for the BEP not only for temporally fading channels but also for spatially correlated channels. The knowledge of the obtained analytical …
The TileCal Optical Multiplexer Board 9U
2011
Abstract TileCal is the hadronic calorimeter of the ATLAS experiment at LHC/CERN. The system contains roughly 10,000 channels of read-out electronics, whose signals are gathered and digitized in the front-end electronics and then transmitted to the counting room through two redundant optical links. Then, the data is received in the back-end system by the Optical Multiplexer Board (OMB) 9U which performs a CRC check to the redundant data to avoid Single Event Upsets errors. A real-time decision is taken on the event-to-event basis to transmit single data to the Read-Out Drivers (RODs) for processing. Due to the low dose level expected during the first years of operations in ATLAS it was deci…
Abstract 5379: Recurrent inactivation of PARD3, a polarity-related gene, in squamous cell carcinomas of the lung.
2013
Abstract In spite of the recent advances in cancer genomics, the genetics underlying the development of lung squamous cell carcinomas (SCC) is still poorly understood. Here, we investigated the contribution of the cell polarity-related gene, PARD3, to lung SCC carcinogenesis. First, we tested for PARD3 alterations in lung cancer cell lines from various histopathological types. The analysis confirmed an intragenic deletion at the H157 cells and unveiled biallelic mutations in another cell line. Both cell lines are SCCs, which circumscribed PARD3 alterations to this lung cancer type. Next, we extended the genetic screening, which included the determination of mutations and of intragenic delet…
Neuroblastoma with MYCN amplification plus 11q deletion: immunohistochemical expression of angiogenic factors
2010
Neuroblastoma (NB) is an extra-cranial solid neoplasm in childhood. Genetic markers as MYCN amplification (MNA) and deletion of 11q (11q ) are considered factors with an adverse prognosis. Usually, an inverse relationship between MNA and 11q is found. Approximately 13% of the MNA cases present with 11q . These cases show a dramatic decline in survival rates. Hypoxia-inducible factor-2a (HIF-2a) protein expression has been described as an indicator of poor outcome, has been correlated with an aggressive phenotype in NB, and serves as a marker for stem cell-like phenotypes. Additionally, HIF-2a positive cells strongly express vascular endothelial growth factor (VEGF) and, as such, could be in…
Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic…
2014
Background: The prognostic impact of segmental chromosome alterations (SCAs) in children older than 1 year, diagnosed with localised unresectable neuroblastoma (NB) without MYCN amplification enrolled in the European Unresectable Neuroblastoma (EUNB) protocol is still to be clarified, while, for other group of patients, the presence of SCAs is associated with poor prognosis. Methods: To understand the role of SCAs we performed multilocus/pangenomic analysis of 98 tumour samples from patients enrolled in the EUNB protocol. Results: Age at diagnosis was categorised into two groups using 18 months as the age cutoff. Significant difference in the presence of SCAs was seen in tumours of patients…
Channel aggregation with guard-band in D-OFDM based CRNs: Modeling and performance evaluation
2016
Channel aggregation (CA) techniques can offer flexible channel allocation and improve overall system performance in multi-channel cognitive radio networks (CRNs). Although many CA techniques have been proposed and studied, the impact of guard-band on CA for channel access has not been addressed in-depth. In this paper, we study the guard-band allocation mechanisms in discontinuous-orthogonal frequency division multiplexing (D-OFDM) based CRNs, and investigate the impact of guard-band sharing on SU flows when CA is enabled. Continuous time Markov chain (CTMC) based models have been developed in order to investigate the stochastic behavior of PU and SU flows. Based on our mathematical analysi…
Solution Processed Micro- and Nano-Bioarrays for Multiplexed Biosensing
2012
This Feature article reports on solution dispensing methodologies which enable the realization of multiplexed arrays at the micro- and nanoscale for relevant biosensing applications such as drug screening or cellular chips.