Search results for "Multivariate Analysi"
showing 4 items of 1084 documents
TP53 mutations and S-phase fraction but not DNA-ploidy are independent prognostic indicators in laryngeal squamous cell carcinoma
2005
To prospectively evaluate the prognostic significance of TP53, H-, K-, and N-Ras mutations, DNA-ploidy and S-phase fraction (SPF) in patients affected by locally advanced laryngeal squamous cell carcinoma (LSCC). Eight-one patients (median follow-up was 71 months) who underwent resective surgery for primary operable locally advanced LSCC were analyzed. Tumor DNA was screened for mutational analysis by PCR/SSCP and sequencing. DNA-ploidy and SPF were performed by flow cytometric analyses. Thirty-six patients (44%) had, at least, a mutation in the TP53 gene. Of them, 22% (8/36) had double mutations and 3% (1/36) had triple mutations. In total, 46 TP53 mutations were observed. The majority (41…
Virtudes escolares percibidas por estudiantes y docentes ecuatorianos: diferencias según sexo, establecimiento y roles
2020
El objetivo del estudio es evaluar la virtuosidad percibida en organizaciones escolares y las diferencias por tipo de centro educativo (fiscal, municipal); sexo (mujer, hombre) y rol (estudiantes, docentes). Se trató de un estudio instrumental basado en el análisis de la estructura factorial y la fiabilidad de un cuestionario para evaluar virtudes percibidas en escuelas (VPOE); y, de un estudio descriptivo transversal que analizó diferencias por sexo, rol y tipo de organizaciones escolares con relación a las virtudes percibidas. Se trabajó con una muestra de 550 estudiantes (49.28 % mujeres) y 105 docentes (47.62% mujeres). El análisis factorial determinó un modelo de cuatro factores que pe…
Assessment of Knowledge, Attitudes, and Propensity towards HPV Vaccine of Young Adult Students in Italy
2020
Background: Human Papillomavirus (HPV) is a common sexually transmitted infection (STI), representing the main cause of genital warts and cervical cancer. This cross-sectional study evaluated knowledge and attitudes about HPV infection, related diseases, and prevention and propensity towards HPV vaccine among undergraduate students. Methods: An online and written survey about HPV and its prevention, targeted to young adults of both genders, was addressed to students attending health sciences and other schools at Universities of Genoa and Bari. Results: The overall median knowledge and attitude scores were 56.3% (25&ndash
Obesity and survival in operable breast cancer patients treated with adjuvant anthracyclines and taxanes according to pathological subtypes: a pooled…
2013
Obesity is an unfavorable prognostic factor in breast cancer (BC) patients regardless of menopausal status and treatment received. However, the association between obesity and survival outcome by pathological subtype requires further clarification. METHODS: We performed a retrospective analysis including 5,683 operable BC patients enrolled in four randomized clinical trials (GEICAM/9906, GEICAM/9805, GEICAM/2003-02, and BCIRG 001) evaluating anthracyclines and taxanes as adjuvant treatments. Our primary aim was to assess the prognostic effect of body mass index (BMI) on disease recurrence, breast cancer mortality (BCM), and overall mortality (OM). A secondary aim was to detect differences o…