Search results for "Multivariate Analysis"

Cost-Effectiveness Analysis: Stress Ulcer Bleeding Prophylaxis with Proton Pump Inhibitors, H2 Receptor Antagonists

2012

Abstract Objectives Proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) present varying pharmacological efficacy in preventing stress ulcer bleeding (SUB) in intensive care units. The literature also reports disparate rates of ventilator-assisted pneumonia (VAP) as side effects of these treatments. We compared the cost-effectiveness of these two prophylactic pharmacological options. Methods We constructed a decision tree with a 60-day time horizon for patients at high risk for developing SUB, receiving either PPIs or H2RAs. For each treatment strategy, patients could be in one of three states of health: SUB, VAP, or no complication. Contemporary, clinically relevant probabilit…

Multivariate equivalence tests for use in pharmaceutical development.

2014

Statistical equivalence analyses are well-established parts of many studies in the biomedical sciences. Also in pharmaceutical development and manufacturing equivalence testing methods are required in order to statistically establish similarities between machines, process components, or complete processes. This article presents a choice of multivariate equivalence testing procedures for normally distributed data as generalizations of existing univariate methods. In all derived methods, variability is interpreted as nuisance parameter. The use of the proposed methods in pharmaceutical development is demonstrated with a comparative analysis of dissolution profiles.

Knowledge of and attitudes to influenza in unvaccinated primary care physicians and nurses

2014

Primary healthcare workers, especially nurses, are exposed to the vast majority of patients with influenza and play an important role in vaccinating patients. Healthcare workers' misconceptions about influenza and influenza vaccination have been reported as possible factors associated with lack of vaccination. The objective of this study was to compare the characteristics of unvaccinated physicians and unvaccinated nurses in the 2011-2012 influenza season. We performed an anonymous web survey of Spanish primary healthcare workers in 2012. Information was collected on vaccination and knowledge of and attitudes to the influenza vaccine. Multivariate analysis was performed using unconditional …

Adverse events as potential predictive factors of activity in patients with advanced hepatocellular carcinoma treated with lenvatinib

2021

Background and Aim: Lenvatinib is a standard of care option in first-line therapy of advanced hepatocellular carcinoma (HCC). In the present study, we aim to identify, in patients with HCC treated with lenvatinib, a possible association between occurrence and grading of adverse events (AEs) and outcome. Methods: We performed a retrospective analysis of 606 Japanese and Italian patients treated with lenvatinib in first-line setting and investigated the possible correlation between the onset of AEs, toxicity grade (G) and outcome measures such as overall survival (OS) and progression-free survival (PFS). Results: The appearance of arterial hypertension G ≥ 2 independently predicted prolonged …

Are better young readers more likely to confuse their mother with their mohter?

2021

One of the most replicated effects in the contemporary word recognition literature is the transposed-letter effect (TL effect): pseudowords created by the transposition of two letters (e.g., MOHTER) are often misread as the real word. This effect ruled out those accounts that assume that letter position is encoded accurately and led to more flexible coding schemes. Here, we examined whether reading skill modulates this effect. The relationship between reading skill and the TL effect magnitude is a contentious issue both empirically and theoretically. The present lexical decision experiment was designed to shed some light on the relationship between reading skill and the TL effect magnitude…

Identification of Volatile Compounds in Blackcurrant Berries: Differences Among Cultivars

2021

Berries of blackcurrant are known to produce a strong flavor. Some previous studies have reported that a given cultivar of blackcurrant can produce berries with a specific profile of volatile compounds. For the Burgundy region in France, the Noir de Bourgogne cultivar is especially important because it is the main ingredient of a liquor with a designation of origin. The aim of the present study was to characterize the volatile fractions of berries from 15 cultivars in order to explore the possibility of using different cultivars for liquor production. The plants were cultivated under the same conditions and harvested in the same year. The volatile fractions of the harvested berries were ana…

Multivariate analysis of historical data (2004-2013) in assessing the possible environmental impact of the Bellolampo landfill (Palermo).

2017

Multivariate analysis was performed on a large data set of groundwater and leachate samples collected during 9 years of operation of the Bellolampo municipal solid waste landfill (located above Palermo, Italy). The aim was to obtain the most likely correlations among the data. The analysis results are presented. Groundwater samples were collected in the period 2004–2013, whereas the leachate analysis refers to the period 2006–2013. For groundwater, statistical data evaluation revealed notable differences among the samples taken from the numerous wells located around the landfill. Characteristic parameters revealed by principal component analysis (PCA) were more deeply investigated, and corr…

Quels sont les patients diabétiques de type 2 à risque d’interactions médicamenteuses ?

2019

Fitness testing in tennis: Influence of anthropometric characteristics, physical performance, and functional test on serve velocity in professional p…

2021

The aims of this study were to examine the relationship between anthropometric variables, physical performance, and functional test with serve velocity regarding tennis players’ level and to design regression models that effectively predict serve velocity. A sample of sixteen male tennis players participated in this study (national level = 8, professional level = 7). Anthropometric measurements (body mass, height, body mass index and body segments) and physical test (hand strength, countermovement jump, jump on serve, and serve velocity) and functional test (medicine ball throw overhead and shot put) were performed. No differences in anthropometrics and physical test were found between nati…

The Cave of Vecchiuzzo: anthropology, paleopathology and hierarchy of the human group with a statistical overview (Petralia Sottana – Palermo, Italy)

2013

Lo scavo della Grotta del Vecchiuzzo fu il primo effettuato nelle Madonie (Sicilia centrooccidentale). Fin dalla sua scoperta avvenuta per mano di Collisani e Carapezza nel 1936, il ritrovamento di manufatti nel vano principale indicò che la grotta era stata abitata. Gli scavi, effettuati a partire dal 1937, indicarono che la grotta era stata adibita ad abitazione o forse a santuario e che era stata abitata intorno al terzo millennio a.C. I resti scheletrici, attribuiti ad almeno quindici individui, sono stati studiati dal punto di vista antropologico, antropometrico e paleopatologico, combinando metodologie tradizionali a quelle più moderne. Sui dati odontometrici raccolti è stata effettua…