Search results for "Musculoskeletal"
showing 10 items of 1714 documents
Clinical prevalence of drooling in infant cerebral palsy
2008
Objective: To determine the prevalence and severity of drooling in infant cerebral palsy (ICP) and analyze the possible surgical, pharmacological, myofunctional and novel alternative approaches to treatment of this disorder. Methods: A clinical study is made of a group of patients with ICP (cohort) and aged between 4 and 34 years, visiting a dental clinic for disabled patients. The classification of Thomas-Stonell and Greenberg was used to assess the presence and severity of drooling. Results: Of the total of 50 patients evaluated (52% males and 48% females), 58% presented drooling (mild in 44.4% and moderate to severe in 27.7%). Conclusion: Over half of the patients with ICP presented droo…
Endocannabinoid Role in Synaptic Plasticity and Learning
2009
Endocannabinoids have recently emerged as versatile modulators of synaptic transmission and can act as retrograde neurotransmitters. As they cannot be stored in synaptic vesicles, endocannabinoid signaling is believed to start ‘on-demand,’ via a stimulus-dependent synthesis from membranous precursors at the postsynaptic site. After synthesis, endocannabinoids bind presynaptically to cannabinoid type 1 (CB1) receptors, leading to a short- or long-term suppression of neurotransmitter release. CB1 receptors are present in a plethora of different synaptic connections in the brain. Electrophysiological and behavioral analyses of mutant mice lacking CB1 receptors and of pharmacologically treated …
Chapter 31 Transcranial magnetic stimulation studies of contralesional space attention deficits
2002
Publisher Summary The power of transcranial magnetic stimulation (TMS) to disrupt and modulate the neural activity in focal brain regions has provided researchers in this field a promising tool to empirically test specific neuropsychological models and constructs of contralesional space attention deficits. A group of studies has used TMS to transiently disrupt the cortical activity of the focal brain areas in normal subjects to replicate the effects of neurological lesions. This chapter discusses a number of studies, using single-pulse, paired-TMS, and repetitive TMS (rTMS) and different experimental paradigms that show how this technique can be of fundamental importance, in elucidating the…
Intra-Articular Injection of Botulinum Toxin for the Treatment of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials
2023
The purpose of the present paper was to review the available evidence on intra-articular botulinum toxin (BTX) injection in the treatment of knee osteoarthritis and to compare it to other conservative treatment options. A systematic review of the literature was performed on the PubMed, Scopus, Cochrane Library, Web of Science, Pedro and Research Gate databases with the following inclusion criteria: (1) randomized controlled trials (RCTs), (2) written in the English language, and (3) published on indexed journals in the last 20 years (2001–2021) dealing with the use of BTX intra-articular injection for the treatment of knee OA. The risk of bias was assessed using the Cochrane Risk of Bias to…
The pain threshold of high-threshold mechanosensitive receptors subsequent to maximal eccentric exercise is a potential marker in the prediction of D…
2017
Background Delayed-onset muscle soreness (DOMS) refers to dull pain and discomfort in people after participating in exercise, sport or recreational physical activities. The aim of this study was to detect underlying mechanical thresholds in an experimental model of DOMS. Methods Randomised study to detect mechanical pain thresholds in a randomised order following experimentally induced DOMS of the non-dominant arm in healthy participants. Main outcome was the detection of the pressure pain threshold (PPT), secondary thresholds included mechanical detection (MDT) and pain thresholds (MPT), pain intensity, pain perceptions and the maximum isometric voluntary force (MIVF). Results Twenty volun…
The impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease
2021
This study investigated the impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease (NAFLD). A total of 63 eligible women randomly participated in the Nordic walking training (AEx, n = 33), or maintained their daily lifestyle (Con, n = 30) during intervention. Bone mineral content (BMC) and density (BMD) of whole body (WB), total femur (TF), femoral neck (FN), and lumbar spine (L2-4) were assessed by dual-energy X-ray absorptiometry. Serum osteocalcin, pentosidine, receptor activator of nuclear factor kappa-B ligand (RANKL) levels were analyzed by ELISA assay. After an 8.6-month intervention, the AEx group maintained their BM…
Selected needling techniques in pain associated with musculoskeletal disorders: a narrative review
2022
Background: Therapies involving various needling techniques are becoming more common treatment methods for musculoskeletal disorders. Aim of the study: To review the most commonly used needling techniques and their effect on the level of pain and functional status of patients with selected musculoskeletal disorders, i.e., lower back pain, upper trapezius muscle (UT) pain, cervicogenic headaches, myofascial pain syndrome (MPS), and chronic pain localized to the knee joint. Material and methods: A review of the academic literature was conducted between December 2021 and January 2022. The needle therapy methods used in the treatment of pain ailments were selected based on publications availabl…
Enkephalin-containing interneurons are specialized to innervate other interneurons in the hippocampal CA1 region of the rat and guinea-pig
1998
Enkephalins are known to have a profound effect on hippocampal inhibition, but the possible endogenous source of these neuropeptides, and their relationship to inhibitory interneurons is still to be identified. In the present study we analysed the morphological characteristics of met-enkephalin-immunoreactive cells in the CA1 region of the rat and guinea-pig hippocampus, their coexistence with other neuronal markers and their target selectivity at the light and electron microscopic levels. Several interneurons in all subfields of the hippocampus were found to be immunoreactive for met-enkephalin. In the guinea-pig, fibres arising from immunoreactive interneurons were seen to form a plexus …
Additional file 2: of Severe asthma features in children: a caseâ control online survey
2016
Criteria for inclusion of children with severe asthma and non-severe persistent asthma. (PDF 25Â kb)
Additional file 1: of Severe asthma features in children: a caseâ control online survey
2016
Criteria for exclusion of children with severe asthma and non-severe persistent asthma. (PDF 11Â kb)