Search results for "Myc"
showing 10 items of 3773 documents
Dietary exposure to mycotoxins through the consumption of commercial bread loaf in Valencia, Spain
2017
Abstract In this study, 80 commercial samples of bread loaves were purchased from different supermarkets located in Valencia (Spain). These samples were investigated for the presence of legislated and non-legislated mycotoxins. Results showed that samples were contaminated with Aflatoxins (AFs), Zearalenone (ZEA) and Enniatins (ENs) with a frequency of 20, 96, and 65% respectively. Aflatoxin B1 (AFB1), Aflatoxin B2 (AFB2) and Aflatoxin G1 (AFG1) were detected with concentrations ranged from 0.5 to 7.1 μg/kg. The samples contaminated with AFB1 showed values exceeding the maximum limit allowed in the EU. The sum of AFs also exceeded the maximum limit allowed in 6 samples. ENs contamination da…
O26 Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young Inf…
2019
BackgroundIn the absence of consensus, the present meta-analysis was performed to determine an optimal dosing regimen of vancomycin for neonates.MethodsA ‘meta-model’ using NONMEM with 4894 concentrations from 1631 neonates was built and Monte Carlo simulations were performed to design an optimal intermittent infusion, aiming at reaching a target AUC0-24 of 400 mg*h/L at steady state in at least 80% of neonates.ResultsA two-compartment model best fitted the data. Current weight, post-menstrual age (PMA) and serum creatinine were the significant covariates for clearance (CL). After model validation, simulations showed that a loading dose (25 mg/kg) and a maintenance dose (15 mg/kg twice dail…
Influence of the storage conditions on some physicochemical and mycological parameters of honey
1994
The authors studied the changes in yeast and mould counts, pH, free and lactone acidity, colour and sugar composition undergone by honeys with water contents of 169, 188 and 220 g kg-1 on storage at refrigeration temperature (4–7°C), room temperature and 28°C for two years. Of the solid culture media assayed, honey agar and osmophilic medium fostered yeast growth while malt-extract agar and yeast-extract-malt-extract agar allowed for better development of filamentous fungi. The yeasts isolated belonged to the genera Saccharomyces, Schizosaccharomyces and Zygosaccharomyces, while filamentous moulds were of the genera Aspergillus, Penicillium, Fusarium and Alternaria. The honeys studied under…
Differential Translational Efficiency of the mRNAs Isolated from Derepressed and Glucose Repressed Saccharomyces cerevisiae
1987
Summary: Carbon catabolite derepression induced changes in the pool of yeast mRNAs translatable in a protein-synthesizing reticulocyte system. Competition experiments with globin mRNA showed that the mRNA population obtained from derepressed cells possessed a higher translational efficiency than mRNA from repressed cells. The mRNAs that could account for the high translational efficiency of the derepressed mRNA were not detected in cells growing in glucose-rich medium. Analysis of protein synthesis in the presence of 7-methylguanosine 5′-phosphate indicated that the initiation factors recognizing the 5′-terminal structure of capped messengers interacted with lower affinity with the represse…
Presence of mycotoxins in Tunisian infant foods samples and subsequent risk assessment
2018
Abstract A study on a set of cereal and cereal-based products (n = 117) intended for infant consumption was performed to determine the natural presence of twenty different mycotoxins by both liquid chromatography and gas chromatography coupled to tandem mass spectrometry (MS/MS). Analytical data showed that 67% of analyzed samples were contaminated by at least one mycotoxin at variable levels. Deoxynivalenol presented the highest incidence (38%) and reached a maximum level of 240 ng/g in a bsissa sample (oat product), higher than the maximum level set for DON in cereal products (200 ng/g). While, enniatin B was found in 25 samples with a maximum level of 316 ng/g found also in a bsissa samp…
PO-0994 Ltri In Paediatrics: Analysis Of An Annual Survey
2014
Background and aims Lower tract respiratory infections (LTRI) are very frequent in paediatric population. We collected epidemiological, etiological and clinical data and correlated them to some variables. Methods We performed an observational study of all children with a LTRI, admitted to our Paediatric Unit from February 2013 to January 2014. The population was grouped in three classes of ages (0–2yr, 3–6yr, >6yr). All patients underwent to a questionnaire focused on exposition to protective and risk factors for respiratory diseases. Results 83 children were included. We grouped them according to discharge diagnosis and analysed the distribution for ages, sex and season of onset. At the ad…
Alterations in Daphnia magna exposed to enniatin B and beauvericin provide additional value as environmental indicators
2022
Mycotoxins beauvericin (BEA) and enniatin B (ENN B) affect negatively several systems and demand more studies as the mechanisms are still unclear. The simultaneous presence of contaminants in the environment manifests consequences of exposure for both animals and flora. Daphnia magna is considered an ideal invertebrate to detect effects of toxic compounds and environmental alterations. In this study, the potential toxicity and the basic mechanism of BEA and ENN B individually and combined were studied in D. magna. Acute and delayed toxicity were evaluated, and transcript levels of genes involved in xenobiotic metabolism (mox, gst, abcb1, and abcc5), reproduction, and oxidative stress (vtg-S…
Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.
2008
The receptor for advanced glycation end products (RAGE) is a 55-kDa type I membrane glycoprotein of the immunoglobulin superfamily. Ligand-induced up-regulation of RAGE is involved in various pathophysiological processes, including late diabetic complications and Alzheimer disease. Application of recombinant soluble RAGE has been shown to block RAGE-mediated pathophysiological conditions. After expression of full-length RAGE in HEK cells we identified a 48-kDa soluble RAGE form (sRAGE) in the culture medium. This variant of RAGE is smaller than a 51-kDa soluble version derived from alternative splicing. The release of sRAGE can be induced by the phorbol ester PMA and the calcium ionophore c…
Evaluation of Mycotoxin Residues on Ready-to-Eat Food by Chromatographic Methods Coupled to Mass Spectrometry in Tandem
2018
Simultaneous determination of twenty-seven mycotoxins in ready-to-eat food samples using &ldquo
Mycotoxins and their consequences in aquaculture: A review
2016
Fish consumption has been increasing worldwide, mainly due to the availability, access and price in relation to other kinds of meat consumption, such as beef, pork, and poultry. Consequently, some concerns begin to emerge, primarily regarding the quality of fish available in the market. Residues could be present in any product of animal origin causing economic losses and putting into a risk human and animal health. Food contamination by mycotoxins is a risk to human and animal health, and it is responsible for significant economic losses. It's very difficult to prove that a disease is a mycotoxicosis, and even when mycotoxins are detected, it is not easy to show that they are the etiologica…