Search results for "Myc"
showing 10 items of 3773 documents
Guanosine 5'-diphosphate 3'-diphosphate (ppGpp) as a negative modulator of polynucleotide phosphorylase activity in a 'rare' actinomycete.
2010
Abstract With the beginning of the idiophase the highly phosphorylated guanylic nucleotides guanosine 5'-diphosphate 3'-diphosphate (ppGpp) and guanosine 5'-triphosphate 3'-diphosphate (pppGpp), collectively referred to as (p)ppGpp, activate stress survival adaptation programmes and trigger secondary metabolism in actinomycetes. The major target of (p)ppGpp is the RNA polymerase, where it binds altering the enzyme activity. In this study analysis of the polynucleotide phosphorylase (PNPase)-encoding gene pnp mRNA, in Nonomuraea sp. ATCC 39727 wild-type, constitutively stringent and relaxed strains, led us to hypothesize that in actinomycetes (p)ppGpp may modulate gene expression at the leve…
Saccharomyces boulardii preparātu aprites salīdzinājums Rīgas aptiekās
2019
Probiotikas ir dzīvi mikroorganismi, kas uzlabo cilvēka veselību. Rauga sēņu Saccharomyces boulardii probiotiku efektivitāte aprakstīta vairākos dubultaklajos klīniskajos pētījumos. Maģistra darba mērķis bija noskaidrot, cik plaši patērēti Saccharomyces boulardii saturošie preparāti trīs Rīgas aptiekās, un kā mainās to lietošanas tendences laika periodā 03.01.2016. – 31.12.2018. Ar aptaujas anketu palīdzību noskaidroju, kādas probiotikas un kādam nolūkam iesaka farmaceiti un farmaceita asistenti, vai uzskata, ka tās lietošana var labvēlīgi ietekmēt kopējo veselības stāvokli, vai ir zināmas nemedikamentozās iespējas, kā normalizēt zarnu mikrofloru. Iegūtie dati liecina, ka visbiežāk pārdotai…
Saccharomyces boulardii lietošanas un aprites apskats Rīgas aptiekā 2016. gadā
2017
Probiotiķi tiek definēti kā dzīvi mikroorganismi, kas dod veselības ieguvumus tā uzņēmējam. Rauga šūnas Saccharomyces boulardii tika konstatētas kā efektīvs probiotiķis vairākos dubultaklajos klīniskajos pētījumos. Bakalaura darba mērķis bija veikt Saccharomyces boulardii saturošo preparātu aprites analīzi Rīgas aptiekā 2016. gadā un noskaidrot iedzīvotāju informētību par Saccharomyces boulardii preparātiem. Darba gaitā tika konstatēts, ka cilvēki zina, kas ir probiotikas, un vairums uzskata, ka probiotiķu lietošana var labvēlīgi ietekmēt cilvēka kopējo veselības stāvokli. Ar aptaujas palīdzību tika konstatēts, ka lielākā daļa no respondentiem nezina kas ir Saccharomyces boulardii, bet pēc …
Challenges Associated with Byproducts Valorization—Comparison Study of Safety Parameters of Ultrasonicated and Fermented Plant-Based Byproducts
2020
In order to promote the efficient use of byproducts from the production of plant-based beverages, which still contain a large amount of nutritional and functional compounds, microbiological and chemical safety characteristics should be evaluated and, if needed, improved. Many challenges are associated with byproducts valorization, and the most important ones, which should be taken into account at the further steps of valorization, are biological and chemical safety. For safety improving, several technological treatments (biological, physical etc.) can be used. In this study, the influence of low-frequency ultrasonication (US) and fermentation with Lactobacillus casei LUHS210 strain, as phys…
Profili di espressione genica associati al metabolismo primario e secondario nel ceppo 166 bldF di Streptomyces coelicolor
Technical improvements for analysis of recalcitrant proteins by LC-MS : the mycorrhiza responsive membrane proteome as a case study
2012
Arbuscular mycorrhizas (AM) are widespread symbiotic associations between plant roots and AM fungi. Deep membrane alterations are the foremost morphological changes occurring in the host plant in response to AM symbiosis. Two-dimensional gel electrophoresis (2-DE) is the workhorse method in AM proteomics. Membrane proteins are under-represented in 2-DE because of their hydrophobicity, low abundance, and precipitation at their isoelectric point, thereby few are the identified membrane proteins involved in sustaining the AM symbiosis. Membrane proteomics is still challenging due to 2-DE related shortcomings, however latest trends and advancements in mass spectrometry (MS)-based quantitative p…
Antibiofilm activity of a novel pyrrolomycin against staphylococcal biofilms of veterinary interest
2011
Diversité des champignons mycorhiziens à arbuscules en association avec Acacia saligna dans différentes régions de la Tunisie
2022
Acacia saligna, appelée également Acacia cyanophylla, est une fabacée arbustive originaire de l'Australie. Cette plante a une grande résilience et s’adapte facilement à de nombreux écosystèmes différents, ce qui lui confère une importance économique forte. De plus, elle forme plusieurs symbioses racinaires avec des microorganismes qui favorisent son développement et améliorent sa résistance vis à vis de différents stress biotiques et abiotiques :(i) les rhizobiums qui fixent l’azote atmosphérique et (ii) les champignons mycorhiziens à arbuscules (CMA) En Tunisie, aucune étude ciblant des microorganismes formant des symbioses racinaires associées à A. saligna n’a été effectuée. Ce travail s’…
Questing abundance of adult taiga ticks Ixodes persulcatus and their Borrelia prevalence at the north-western part of their distribution
2020
Background Because ixodid ticks are vectors of zoonotic pathogens, including Borrelia, information of their abundance, seasonal variation in questing behaviour and pathogen prevalence is important for human health. As ticks are invading new areas northwards, information from these new areas are needed. Taiga tick (Ixodes persulcatus) populations have been recently found at Bothnian Bay, Finland. We assessed seasonal variation in questing abundance of ticks and their pathogen prevalence in coastal deciduous forests near the city of Oulu (latitudes 64–65°) in 2019. Methods We sampled ticks from May until September by cloth dragging 100 meters once a month at eight study sites. We calculated a…
Efficacy of Rapamycin as Inducer of Hb F in Primary Erythroid Cultures from Sickle Cell Disease and β-Thalassemia Patients.
2015
Phenotypic improvement of hemoglobinopathies such as sickle cell disease and β-thalassemia (β-thal) has been shown in patients with high levels of Hb F. Among the drugs proposed to increase Hb F production, hydroxyurea (HU) is currently the only one proven to improve the clinical course of these diseases. However, Hb F increase and patient's response are highly variable, indicating that new pharmacological agents could be useful for patients not responding to HU or showing a reduction of response during long-term therapy. In this study we evaluated the efficacy of rapamycin, a lypophilic macrolide used for the prevention of acute rejection in renal transplant recipients, as an inducer of Hb…