Search results for "Mycobacterium tuberculosis complex"

showing 3 items of 23 documents

Mycobacterium tuberculosis molecular evolution in western Mediterranean Island of Sicily and Sardinia

2004

Abstract In this study, a total of 204 Mycobacterium tuberculosis DNAs from Sicily ( n = 144) and Sardinia ( n = 60) were studied by three genotyping methods. Results were analyzed both within and across islands, to define the phylogeographical specificities of the genotypes, look for their diversity and infer a molecular evolutionary scenario. A strong link between geography and tuberculosis genotypes was observed in Sardinia. The results were also matched against a world-wide genetic diversity database to compare the population structure of the tubercle bacilli in the islands. Eight common genotypes between Sicily, Sardinia and continental Italy were found which underlines the influences …

Microbiology (medical)DNA BacterialGenotypeSardiniaMicrobiologyMycobacterium tuberculosisEvolution MolecularPhylogeneticsMolecular evolutionGeneticsHumansTuberculosisMolecular BiologyGenotypingSicilyEcology Evolution Behavior and SystematicsPhylogenyGenetic diversitybiologyHuman evolutionary geneticsGenetic VariationMycobacterium tuberculosisbiology.organism_classificationhumanitiesInfectious DiseasesMycobacterium tuberculosis complexItalyEvolutionary biologyMycobacterium tuberculosis complexMolecular evolutionMediterranean Islands
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Snapshot of Moving and Expanding Clones of Mycobacterium tuberculosis and Their Global Distribution Assessed by Spoligotyping in an International Stu…

2003

ABSTRACT The present update on the global distribution of Mycobacterium tuberculosis complex spoligotypes provides both the octal and binary descriptions of the spoligotypes for M. tuberculosis complex, including Mycobacterium bovis , from >90 countries (13,008 patterns grouped into 813 shared types containing 11,708 isolates and 1,300 orphan patterns). A number of potential indices were developed to summarize the information on the biogeographical specificity of a given shared type, as well as its geographical spreading (matching code and spreading index, respectively). To facilitate the analysis of hundreds of spoligotypes each made up of a binary succession of 43 bits of information, …

Microbiology (medical)DNA BacterialMycobacterium bovisMolecular EpidemiologyTuberculosisMolecular epidemiologybiologyEcologyMycobacteriology and Aerobic ActinomycetesMycobacterium tuberculosisbiology.organism_classificationmedicine.diseaseMycobacterium bovisBacterial Typing TechniquesMycobacterium tuberculosisMycobacterium tuberculosis complexEvolutionary biologymedicineHumansTuberculosisDNA IntergenicFar EastCladeDatabases Nucleic AcidMycobacterium africanum
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Towards next-generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics.

2020

5 páginas, 2 figuras. AVAILABILITY AND IMPLEMENTATION: The database of non-tuberculous mycobacteria assemblies can be accessed at: 10.5281/zenodo.3374377. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online: http://dx.doi.org/10.1093/bioinformatics/btz729

Statistics and ProbabilityTuberculosisGenomicsComputational biologyBiologyBiochemistryMycobacterium tuberculosis03 medical and health sciencesmedicineHumansTuberculosisDiscovery NotesMolecular Biology030304 developmental biologyComparative genomics0303 health sciences030306 microbiologyScale (chemistry)GenomicsMycobacterium tuberculosismedicine.diseasebiology.organism_classificationGenome Analysis3. Good healthComputer Science ApplicationsComputational MathematicsComputational Theory and MathematicsMycobacterium tuberculosis complexMolecular targetsIdentification (biology)BiomarkersBioinformatics (Oxford, England)
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