Search results for "Mycotoxicity"

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Mitochondrial transcriptional study of the effect of aflatoxins, enniatins and carotenoids in vitro in a blood brain barrier model

2020

C. maxima (var. Delica), a variety of pumpkin, is well known for its high concentration on carotenoids, possessing dietary benefits and antioxidant properties. Aflatoxins and enniatins are common mycotoxins present in food and feed with an extended toxicity profile in humans and animals. Both types of substances reach a wide range of tissues and organs and have the capability to penetrate the blood brain barrier. Since carotenoids and mycotoxins have been reported to modify diverse mitochondrial processes individually, transcriptional in vitro studies on human epithelial cells ECV 304 were conducted to analyze the relative expression of 13 mitochondria related genes. ECV 304 cells were diff…

AflatoxinMitochondrial DNAAntioxidantmedicine.medical_treatmentAlzheimer Antioxidants Mycotoxicity Neurodegenerative diseases Carotenoids qPCR ECV 304MitochondrionToxicologyBlood–brain barrierAntioxidantsCell LineNOchemistry.chemical_compoundAflatoxinsCucurbitaDepsipeptidesHuman Umbilical Vein Endothelial CellsmedicineHumansECV 304MycotoxinMycotoxicityCarotenoidchemistry.chemical_classificationLS9_6Neurodegenerative diseasesfood and beveragesGeneral MedicineCarotenoidsIn vitroMitochondriaqPCRmedicine.anatomical_structureElectron Transport Chain Complex ProteinschemistryBiochemistryBlood-Brain BarrierAlzheimerFood Science

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