Search results for "Myocardiocyte"

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The involvement of MMP-2 and MMP-9 in heart exercise-related angiogenesis

2013

Background Little is known about the involvement of matrix metalloproteinases (MMPs) in cardiac vascular remodelling induced by exercise. Our aim was to evaluate and localize MMP-2 and MMP-9’s activities in relation to capillary proliferation in mouse hearts trained for 15, 30 and 45 days. Methods Sixty-three mice were randomly assigned to 7 groups: four control sedentary groups (C0, C15, C30 and C45) and three groups trained by an endurance protocol (T15, T30 and T45). MMP-2 and MMP-9 were examined with zymography and immunostaining analyses. Capillary proliferation was evaluated counting the number of CD31-positive cells. Results Different activity patterns of the latent form of both MMPs…

Malemedicine.medical_specialtyPathologyCapillary growthAngiogenesisNeovascularization PhysiologicBiologyMatrix metalloproteinaseGeneral Biochemistry Genetics and Molecular BiologyVascular remodelling in the embryoNeovascularizationMicePhysical Conditioning AnimalInternal medicineCardiac remodellingmedicineAnimalsAerobic exerciseZymographyMyocardiocyteAerobic trainingMedicine(all)Settore M-EDF/02 - Metodi E Didattiche Delle Attivita' SportiveBiochemistry Genetics and Molecular Biology(all)ResearchCapillary growthGeneral MedicineCoronary VesselsCapillariesPlatelet Endothelial Cell Adhesion Molecule-1Matrix metalloproteinasesEndocrinologyMatrix Metalloproteinase 9Capillary growth Matrix metalloproteinases Aerobic training Myocardiocyte Cardiac remodellingMatrix Metalloproteinase 2Electrophoresis Polyacrylamide Gelmedicine.symptomImmunostainingJournal of Translational Medicine
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The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium

2021

Adipose tissue (AT) biology is linked to cardiovascular health since obesity is associated with cardiovascular disease (CVD) and positively correlated with excessive visceral fat accumulation. AT signaling to myocardial cells through soluble factors known as adipokines, cardiokines, branched-chain amino acids and small molecules like microRNAs, undoubtedly influence myocardial cells and AT function via the endocrine-paracrine mechanisms of action. Unfortunately, abnormal total and visceral adiposity can alter this harmonious signaling network, resulting in tissue hypoxia and monocyte/macrophage adipose infiltration occurring alongside expanded intra-abdominal and epicardial fat depots seen …

obesityEndocrinology Diabetes and MetabolismAdipokineAdipose tissueAdipose tissueMyocardiocytesInflammationContext (language use)ReviewBioinformaticsDiseases of the endocrine glands. Clinical endocrinologyCoronary artery diseasechemistry.chemical_compoundEndocrinologyAdipocytemicrobiotamedicineHumansMyocytes CardiacMyocardial infarctionObesityInflammationbusiness.industryMyocardiumMicrobiotaRC648-665medicine.diseaseCor MalaltiesmyocardiocytesAdipose TissuechemistryObesitatmedicine.symptombusinessDysbiosisSignal Transduction
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