Search results for "Myositis"

Moving from Dermatomyositis Associated with Anti-Melanoma Differentiation-Associated Gene 5 Antibody to Anti-Melanoma Differentiation-Associated Gene…

2018

International audience

Myositis Ossificans of the temporalis muscle : case report

2007

Los autores presentan un caso poco frecuente de miositis osificante del músculo temporal en un paciente varón de 51 años que se manifiesta con limitación de la apertura oral, con masa firme y dura en la fosa temporal derecha. La tomografia axial computerizada (TC) reveló una masa de densidad ósea localizada en la región temporal derecha, que unía el hueso temporal derecho con la apófisis coronoides y una imagen de pseudo-articulación en su porción media. La miositis osificante traumática es un tumor benigno que se localiza frecuentemente en las extremidades de los adolescentes. Los casos en el esqueleto craneofacial son raros. En esta localización, los músculos masetero y esternocleidomasto…

Tubuloreticular structures (TRS) and cylindric confronting cisternae (CCC) in childhood dermatomyositis.

1989

Tubuloreticular structures (TRS) and cylindric confronting cisternae (CCC) have been observed in circulating lymphocytes and in the muscle of six children with dermatomyositis. The presence of TRS was seen in all cases investigated, the number of CCC increased in various cells with the severity of the disease. Extensive formation of TRS and CCC in childhood dermatomyositis probably reflects local or systemic alpha-interferon production and suggests that some viral factor is responsible for the disease.

Disease Specific Autoantibodies in Idiopathic Inflammatory Myopathies

2019

Idiopathic inflammatory myopathies represent still a diagnostic and therapeutic challenge in different disciplines including neurology, rheumatology, and dermatology. In recent years, the spectrum of idiopathic inflammatory myopathies has been significantly extended and the different manifestations were described in more detail leading to new classification criteria. A major breakthrough has also occurred with respect to new biomarkers especially with the characterization of new autoantibody-antigen systems, which can be separated in myositis specific antibodies and myositis associated antibodies. These markers are detectable in approximately 80% of patients and facilitate not only the diag…

Evidence for the utility of cfDNA plasma concentrations to predict disease severity in COVID-19

2021

AbstractCOVID-19 is a pandemic caused by the highly infective SARS-CoV-2. There is a need for biomarkers not only for overall prognosis but also for predicting the response to treatments and thus for improvements in the clinical management of patients with COVID-19. Circulating cell-free DNA (cfDNA) has emerged as a promising biomarker in the assessment of various disease conditions. The aim of this retrospective and observational pilot study was to examine the potential value of cfDNA plasma concentrations as a correlative biomarker in hospitalized COVID-19 patients. Lithium-Heparin plasma samples were obtained from twenty-one COVID-19 patients during hospitalization in the University Medi…

Der Anstieg einiger Serumenzyme (GOT, LDH, CPK, MK) nach Ganzk�rpermuskelmassage und seine Bedeutung bei Dermatomyositis

1972

25 gesunde Normalpersonen wiesen 8 Std nach einer Ganzkorpermuskelmassage einen signifikanten Aktivitatsanstieg der Serumenzyme GOT, LDH, CPK und MK auf, wobei die MK im pathologischen Bereich liegt (Durchschnittswerte vor Massage: GOT: 10,97 mE/ml, LDH: 154,78 mE/ml, CPK: 18,28 mE/ml, MK: 15,79 mE/1000 ml; Durchschnittswerte 8 Std nach Massage: GOT: 16,84 mE/ml, LDH: 179,82 mE/ml, CPK: 27,36 mE/ml, MK: 21,74 mE/1000 ml). Die diskutierten, moglichen Ursachen gebieten Zuruckhaltung mit Massagen und analogen medico-mechanischen Masnahmen bei Dermatomyositis.

Paradoxical attenuation of leukocyte rolling in response to ischemia- reperfusion and extracorporeal blood circulation in inflamed tissue.

2005

In contrast to acute preparations such as the exteriorized mesentery or the cremaster muscle, chronically instrumented chamber models allow one to study the microcirculation under “physiological” conditions, i.e., in the absence of trauma-induced leukocyte rolling along the venular endothelium. To underscore the importance of studying the naive microcirculation, we implanted titanium dorsal skinfold chambers in hamsters and used intravital fluorescence microscopy to study venular leukocyte rolling in response to ischemia-reperfusion injury or extracorporeal blood circulation. The experiments were performed in chambers that fulfilled all well-established criteria for a physiological microcir…

The skin in autoimmune diseases-Unmet needs.

2016

Treatment of skin manifestations in systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and dermatomyositis (DM) is based on the results of only few randomized controlled trials. The first-line treatment for disfiguring and widespread cutaneous involvement in SLE is antimalarials, but some patients are therapy resistant. Recently, the monoclonal antibody belimumab was approved for SLE as an adjunct therapy for patients with autoantibody-positive disease who despite standard therapy show high disease activity, intolerance of other treatments, or an unacceptably high need for corticosteroids. However, a validated skin score has not been used to confirm the efficacy of belimumab on m…

Myositis ossificans progressiva

1992

Myositis ossificans of the masseter muscle: A rare location. Report of a case and review of literature

2016

Background Myositis Ossificans is a rare heterotopic bone formation within a muscle being the masticatory muscles exceptionally involved. In most cases there is a previous trauma, bearing in mind that there may be many other etiologies. CT scan and panoramic radiographs along with histological findings are essential diagnostic aids. Case Desciption We report a rare case of MO of masseter muscle in 49 years-old woman after repetitive wisdom tooth infection with the discussion of clinical, radiological and histological features. Clinical Implications MO is a rare disease of masticatory muscles being the masseter the most frequently affected. Wide surgical excision with free margins is the tre…