Search results for "N 1"
showing 10 items of 1053 documents
Individual and Synergistic Effects of IL-5 and IL-13 on Trans-Compartmental Activation and Migration of Eosinophils and Murine Asthma Features
2016
A microcosm experiment to evaluate the influence of location and quality of plant residues on residue decomposition and genetic structure of soil mic…
2007
The effects of location (soil surface vs. incorporated in soil) and nature of plant residues on degradation processes and indigenous microbial communities were studied by means of soil microcosms incubation in which the different soil zones influenced by decomposition i.e. residues, soil adjacent to residues (detritusphere) and distant soil unaffected by decomposition (bulk soil) were considered. Plant material decomposition, organic carbon assimilation by the soil microbial biomass and soil inorganic N dynamics were studied with 13 C labelled wheat straw and young rye. The genetic structure of the community in each soil zone were compared between residue locations and type by applying B- a…
Transportan 10 Induces Perturbation and Pores Formation in Giant Plasma Membrane Vesicles Derived from Cancer Liver Cells
2023
Continuous progress has been made in the development of new molecules for therapeutic purposes. This is driven by the need to address several challenges such as molecular instability and biocompatibility, difficulties in crossing the plasma membrane, and the development of host resistance. In this context, cell-penetrating peptides (CPPs) constitute a promising tool for the development of new therapies due to their intrinsic ability to deliver therapeutic molecules to cells and tissues. These short peptides have gained increasing attention for applications in drug delivery as well as for their antimicrobial and anticancer activity but the general rules regulating the events involved in cell…
Standartizācija kā līdzeklis tulkošanas pakalpojumu kvalitātes uzlabošanai
2015
Šī darba pētījuma objekts ir standarti, kuri attiecas uz tulkošanas nozari. Šī darba mērķis ir analizēt to lomu tulkošanas pakalpojumu kvalitātes uzlabošanas procesā. Eiropas Savienības standarts EN 15038 "Tulkošanas pakalpojumi. Pakalpojumu kvalitātes prasības" ir pirmais Eiropas tulkošanas pakalpojumu nozares standarts. Standarts ietver tulkošanas procesu un visus citus attiecīgos aspektus, kuri ir iesaistīti tulkošanas pakalpojumu sniegšanā, ekstralingvistiskajā un intralingvistiskajā līmenī. Teorētiskajā daļā ir izskatīta kvalitātes jēdziena definīcija un tās svarīgums uzņēmējdarbībā. Autors pēta standartizācijas procesu un tā sniegto labumu. Darbā uzmanība ir pievērsta arī tulkojuma kv…
Peptide–Membrane Interactions Monitored by Fluorescence Lifetime Imaging: A Study Case of Transportan 10
2021
The interest on detailed analysis of peptide-membrane interactions is of great interest in both fundamental and applied sciences as these may relate to both functional and pathogenic events. Such interactions are highly dynamic and spatially heterogeneous, making the investigation of the associated phenomena highly complex. The specific properties of membranes and peptide structural details, together with environmental conditions, may determine different events at the membrane interface, which will drive the fate of the peptide-membrane system. Here, we use an experimental approach based on the combination of spectroscopy and fluorescence microscopy methods to characterize the interactions …
The role of thrombospondin-1 in biomaterial integration of porous polyethylene implants in vivo
2019
Cuando la historia está presente: Argumentos a favor de la sociología histórica
2019
Sociology and history have maintained a discontinuous relationship and a permanent discussion. Classical sociology is intrinsically historical, but after the first theoretical synthesis the dialogue between both disciplines was extinguished and it has often been necessary to defend the need for the historical view in sociology from the margins of the dominant paradigm. However, as a specialty or subdiscipline, historical sociology has consolidated its own academic space and a strong theoretical, methodological and conceptual body. In Spain this process of institutionalization has not yet success. In this article we expose a few arguments in defense of historical sociology, both theoretical …
Justifier les dépenses vestimentaires dans la recette générale de toutes les finances du duc de Bourgogne Philippe le Bon
2014
La série comptable de la recette générale de toutes les finances sous le duc de Bourgogne Philippe le Bon, remarquablement bien conservée, permet une approche fine et précise de la conjoncture vestimentaire de l’hôtel ducal, mais aussi, dans une large mesure, de l’évolution de la comptabilité. Les outils de contrôle importants, à tous les niveaux, mais aussi les changements de personnel et les réformes régulières témoignent des difficultés de l’autorité ducale à maîtriser ses finances. Le compte, outil de travail personnel, évolue en fonction de la personnalité du receveur et des contraintes auxquelles il est soumis. Ces contraintes se renforcent à l’orée des années 1440, dans un contexte g…
Absence of mutation at the GAP-related domain of the neurofibromatosis type 1 gene in sporadic neurofibrosarcomas and other bone and soft tissue sarc…
1995
The NF1 gene encodes neurofibromin, a GTPase-activating protein containing a GAP-related domain (NF1-GRD) that is capable of downregulating ras by stimulating ras intrinsic GTPase activity. We tested 44 sarcomas, nine of which corresponded to sporadic neurofibrosarcomas, for mutations at the NF1-GRD by the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique, finding no mutation in every sample tested. We suggest that inactivation of the NF1-GRD by gene mutation seems not to be an important event in the tumorigenesis of sarcomas.
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
2004
AbstractPolyglutamine expansion (polyQ) in the protein huntingtin is pathogenic and responsible for the neuronal toxicity associated with Huntington's disease (HD). Although wild-type huntingtin possesses antiapoptotic properties, the relationship between the neuroprotective functions of huntingtin and pathogenesis of HD remains unclear. Here, we show that huntingtin specifically enhances vesicular transport of brain-derived neurotrophic factor (BDNF) along microtubules. Huntingtin-mediated transport involves huntingtin-associated protein-1 (HAP1) and the p150Glued subunit of dynactin, an essential component of molecular motors. BDNF transport is attenuated both in the disease context and b…