Search results for "N 1"
showing 10 items of 1053 documents
IL-17 and TNF-α Are Key Mediators of Moraxella catarrhalis Triggered Exacerbation of Allergic Airway Inflammation
2017
Alterations of the airway microbiome is often associated with pulmonary diseases. For example, detection of the bacterial pathogen Moraxella catarrhalis in the upper airways is linked with an increased risk to develop or exacerbate asthma. However, the mechanisms by which M. cattarhalis augments allergic airway inflammation (AAI) remains unclear. We here characterized the cellular and soluble mediators of M. catarrhalis triggered excacerbation of AAI in wt and IL-17 deficient as well as in animals treated with TNF-alpha and IL-6 neutralizing antibodies. We compared the type of inflammatory response in M. catarrhalis infected, HDM-allergic and animals infected with M. catarrhalis at differen…
Marx y Engels y la división sexual del trabajo en la familia: ambigüedades, equívocos y vacíos teóricos
2018
Dada la importante influencia de Marx y Engels en el análisis de la estructura social, no sorprende el notable impacto de su obra en el estudio del papel de la mujer en la familia. Sin embargo, su herencia en este ámbito sociológico ha dado lugar a interpretaciones muy polarizadas. Este artículo quiere aportar algo de luz evidenciando las contradicciones del marxismo al estudiar el papel de la mujer en la familia. Para ello se comparan las contribuciones de Marx y Engels para calibrar posibles diferencias en las posturas de dos autores que en otros ámbitos han presentado un pensamiento muy homogéneo. Los resultados obtenidos permiten afirmar que, a pesar de su innegable influencia en el pen…
Prolonging in utero-like oxygenation after birth diminishes oxidative stress in the lung and brain of mice pups☆
2013
Background Fetal-to-neonatal transition is associated with oxidative stress. In preterm infants, immaturity of the antioxidant system favours supplemental oxygen-derived morbidity and mortality. Objectives To assess if prolonging in utero-like oxygenation during the fetal-to-neonatal transition limits oxidative stress in the lung and brain, improving postnatal adaptation of mice pups. Material and methods Inspiratory oxygen fraction (FiO2) in pregnant mice was reduced from 21% (room air) to 14% (hypoxia) 8–12 h prior to delivery and reset to 21% 6–8 h after birth. The control group was kept at 21% during the procedure. Reduced (GSH) and oxidized (GSSG) glutathione and its precursors [γ-glut…
Scientific opinion on an application by Dow AgroSciences LLC (EFSA-GMO-NL-2012-106) for the placing on the market of genetically modified herbicide-t…
2017
Abstract Soybean DAS‐44406‐6 expresses 5‐enolpyruvyl‐shikimate‐3‐phosphate synthase (2mEPSPS), conferring tolerance to glyphosate‐based herbicides, aryloxyalkanoate dioxygenase (AAD‐12), conferring tolerance to 2,4‐dichlorophenoxyacetic acid (2,4‐D) and other related phenoxy herbicides, and phosphinothricin acetyl transferase (PAT), conferring tolerance to glufosinate ammonium‐based herbicides. The molecular characterisation data and bioinformatics analyses did not identify issues requiring assessment for food/feed safety. The agronomic and phenotypic characteristics revealed no relevant differences between soybean DAS‐44406‐6 and its conventional counterpart, except for pod count, seed cou…
Intervención en Libia: La responsabilidad de proteger a debate
2011
Resumen El trabajo analiza el origen y evolución del concepto de la responsabilidad de proteger, sus antecedentes en la década de los noventa del S. XX, su formulación en el Informe sobre La responsabilidad de proteger, y su consolidación posterior con especial atención al Documento Final de la Cumbre de 2005. Se examina asimismo el modo en que se ha aplicado esta norma emergente en la Resolución 1973 del Consejo de Seguridad, de 17 de marzo de 2011, que ha autorizado el uso de la fuerza en Libia. Y se concluye que casi todas las limitaciones y objeciones que se están planteando en relación con esta intervención, probablemente son consustanciales al modo en que actualmente se ponen en prác…
Sans rire. Les journaux socialistes français, juillet 1830 - juin 1848
2015
International audience
Effect of different co-solvents on biodiesel production from various low-cost feedstocks using Sr–Al double oxides
2020
The main objective of the present paper comprises the investigation of biodiesel production from low-cost feedstock such as lard oil and waste cooking oil (WCO) using Sr-Al double oxides. Nanocatalyst was characterised FTIR, XRD, SEM, TEM, BET and XPS. The Sr:Al with 3:1 molar ratio showed the best catalytic activity in the conversion of both oils to fatty acid methyl ester. The effect of acetone and tetrahydrofuran (THF) as a co-solvent for transesterification were compared and the best result was obtained with 5 % THF. The mutual effect of the nanocatalyst and co-solvent on biodiesel production was investigated. The characterisation of biodiesel synthesised from lard oil and WCO was perfo…
On flora semantics in house names found in Vidzeme: materials contained in the 1826 counting of souls in Vidzeme province
2014
On flora semantics in house names found in Vidzeme: materials contained in the 1826 counting of souls in Vidzeme province The information of the counting of souls containing both house names and names of individuals is an essential aspect of historical onomastics. The first counting of souls in Vidzeme took place in 1782 and coincided with the 4 th analogous census of the provinces of Russia. Subsequently these took place at irregular intervals, the 5 th in 1795, the 6 th in 1811, the 7 th in 1816, the 8 th in 1834, the 9 th in 1850, and the final, 10 th in 1858. The number of house names entered in the 1826 counting of souls in Vidzeme province (guberna) is 14,500, including those of peasa…
Reciprocal influence of B cells and tumor macro and microenvironments in the ApcMin/+ model of colorectal cancer
2017
One of the most fascinating aspects of the immune system is its dynamism, meant as the ability to change and readapt according to the organism needs. Following an insult, we assist to the spontaneous organization of different immune cells which cooperate, locally and at distance, to build up an appropriate response. Throughout tumor progression, adaptations within the systemic tumor environment, or macroenvironment, result in the promotion of tumor growth, tumor invasion and metastasis to distal organs, but also to dramatic changes in the activity and composition of the immune system. In this work, we show the changes of the B-cell arm of the immune system following tumor progression in the…
Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview
2021
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced by macrophages and dendritic cells, in response to exogenous or endogenous signals, and drives the differentiation and activation of T helper 17 (Th17) cells with subsequent production of IL-17A, IL-17F, IL-6, IL-22, and tumor necrosis factor α (TNF-α). Although IL-23 plays a pivotal role in the protective immune response to bacterial and fungal infections, its dysregulation has been shown to exacerbate chronic immune-mediated inflammation. Well-established experimental data support the concept that IL-23/IL…